Transition-metal catalyzed asymmetric reactions under continuous flow from 2015 to early 2020

Phosphorus coordinated Rh single-atom sites on nanodiamond as highly regioselective catalyst for hydroformylation of olefins

“…Homogeneous Rh catalysts with various phosphorus ligands have been widely used in this process for the superior activity and selectivity 6 – 12 . Despite intensive research in homogeneous Rh-catalyzed hydroformylation, only a few examples succeeded in industry up to now 13 – 16 . Catalyst separation is an important issue, and remains challenging in most cases.…”

Continuous flow technology-a tool for safer oxidation chemistry

“…The selective oxidation of organic molecules is required for the preparation of many natural products, pharmaceuticals and materials in both academia and industry. 1–5 A vast range of oxidants have been developed over the years to enable a wide range of selective functional group oxidations in terms of selectivity, yield, atom economy and processability. However, since the majority of traditional methods exhibit poor selectivity and generate significant quantities of unwanted byproducts derived from the use of stoichiometric amounts of oxidants, there is still an evident need for methodology improvement with respect to environmental and economic issues.…”

Phosphafluorenyl lithiums: direct synthesis from white phosphorus, structure and diversified synthons

“…Phospholides are the key intermediates to realize many transformations for the synthesis of organophosphorus compounds, which have played a very important role in chemical research and our daily life [1][2][3]. As the cyclic phospholides, phospholyl anions (Scheme 1-I) have received much attention because they can stabilize many metal complexes or act as the precursors for the synthesis of phospholes (Scheme 1-II) [4][5][6][7][8][9][10].…”

“…As the cyclic phospholides, phospholyl anions (Scheme 1-I) have received much attention because they can stabilize many metal complexes or act as the precursors for the synthesis of phospholes (Scheme 1-II) [4][5][6][7][8][9][10]. In contrast to the rich chemistry of phospholyl anions, phosphafluorenyl anions (Scheme 1-III) are only proposed as the critical intermediates for the synthesis of phosphafluorenes (dibenzophospholes) (Scheme 1-IV), which have a wide range of applications because they can serve as (1) suitable ligands in organometallic chemistry and organic synthesis methodology [11][12][13]; (2) organocatalysts in some classic organic reactions (e.g., Appel reaction, Staudinger reaction) [14,15]; and (3) organic optoelectronic materials [16][17][18][19]. Metalmediated P-C bond cleavage of Ph-substituted phosphafluorenes is the classic method for the in situ generation of phosphafluorenyl anions (e.g., lithium, sodium, potassium) (Scheme 2a) [20][21][22][23].…”