Transition metal catalysed alkylation of pyridines and indoles

“…In addition, Grigg and Savic [83] showed that the reaction of benzoylpyridines with triethoxyvinylsilane occurs ortho to the acetyl group on the more electron-deficient pyridine ring (Scheme 19.50). Using the Murai reaction, Weber et al…”

Section: Methods Developmentmentioning

confidence: 99%

CH Bond Alkylation (Including Hydroarylation of Alkenes)

Jean‐Gérard

Jazzar

Baudoin

2013

Metal‐Catalyzed Cross‐Coupling Reactions and More

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“…74 They surmised that an acetyl group could direct the substitution at either C3 or C4 faster than at the C2 position.…”

Section: C4–h-functionalizationmentioning

confidence: 99%

Recent advances in the C–H-functionalization of the distal positions in pyridines and quinolines

2015

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This review summarizes recent developments in the C–H-functionalization of the distal positions of pyridines, quinolines and related azaheterocycles. While the functionalization of the C2 position has been known for a long time and is facilitated by the proximity to N1, regioselective reactions in the distal positions are more difficult to achieve and have only emerged in the last decade. Recent advances in the transition metal-catalyzed distal C–H-functionalization of these synthetically-important azaheterocycles are discussed in detail, with the focus on the scope, site-selectivity and mechanistic aspects of the reactions.

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Transition metal catalysed alkylation of pyridines and indoles

Cited by 75 publications

References 17 publications

Catalytic Addition of C – H Bonds to C – C Multiple Bonds

Catalytic Addition of C – H Bonds to C – C Multiple Bonds

CH Bond Alkylation (Including Hydroarylation of Alkenes)

Recent advances in the C–H-functionalization of the distal positions in pyridines and quinolines

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Transition metal catalysed alkylation of pyridines and indoles

Cited by 75 publications

References 17 publications

Catalytic Addition of C – H Bonds to C – C Multiple Bonds

Catalytic Addition of C – H Bonds to C – C Multiple Bonds

CH Bond Alkylation (Including Hydroarylation of Alkenes)

Recent advances in the C–H-functionalization of the distal positions in pyridines and quinolines

Contact Info

Product

Resources

About

Catalytic Addition of C – H Bonds to C – C Multiple Bonds

Catalytic Addition of C – H Bonds to C – C Multiple Bonds