Transition dynamics and optogenetic controls of generalized periodic epileptiform discharges

Shen, Zhuan; Zhang, Honghui; Cao, Zilu; Yan, Liang; Zhao, Yuzhi; Du, Lin; Deng, Zichen

doi:10.1016/j.neunet.2022.01.022

Cited by 11 publications

(3 citation statements)

References 49 publications

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“…We found that Mir155hg knockdown inhibited the abnormal discharge and markedly decreased EEG power in SE rats. It is widely accepted that generalized epileptiform discharges contribute to abnormal synaptic connections and neural circuitry [50,51]. A strong relationship between long-lasting epileptic discharges and cognitive impairment of SE also has been reported in much literature [30,52].…”

Section: Discussionmentioning

confidence: 96%

LncRNA Mir155hg Knockdown Attenuates Inflammation and Cognitive Impairment through regulating the NF-κΒ signaling pathway in a Rat Model of Status Epilepticus

Wang

Cui

Shao

et al. 2022

Preprint

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Status epilepticus (SE) is a common neurological emergency that may lead to permanent brain damage or death. Microglia-mediated inflammation play a significant role in the pathogenesis of SE. As precursor of miR-155, long non-coding RNA (lncRNA) Mir155hg has been characterized as inflammation-related lncRNA in the nervous system. However, the molecular mechanism of how Mir155hg regulate inflammation in SE is still not elucidated. The current study aims to investigate the potential role of Mir155hg in SE-induced inflammation. In vitro experiments, the N-methyl-D-aspartate (NMDA) was used to induce inflammation in primary microglia. In vivo, the SE rat model was established with lithium chloride-pilocarpine. The results demonstrated that lncRNA Mir155hg was highly expressed in NMDA-treated microglia and the hippocampus of SE rats. Down-regulated Mir155hg suppressed inflammatory cytokines (IL-1β, IL-6 and TNF-α) both in microglia and SE rats. Meanwhile, the study confirmed that Mir155hg knockdown decreased the level of NF-κΒ p-p65 via Socs1 in microglia. Animal data indicated that Mir155hg knockdown terminated epileptiform discharges during SE. Furthermore, the study showed that Mir155hg knockdown repressed microglial proliferation, alleviated hippocampal neuron damage, and improved cognitive impairment induced by SE. Taken together, our findings demonstrate that lncRNA Mir155hg regulates the inflammation through the miR-155/Socs1/NF-κΒ axis in SE rat.

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Section: Discussionmentioning

confidence: 96%

LncRNA Mir155hg Knockdown Attenuates Inflammation and Cognitive Impairment through regulating the NF-κΒ signaling pathway in a Rat Model of Status Epilepticus

Wang

Cui

Shao

et al. 2022

Preprint

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“…The prolonged recovery of interneurons secondary to a structural lesion or frequent, intense depolarization (e.g., SE) results in disinhibition of adjacent local field potentials, permitting synchronization and generation of large-scale discharges, likely detected as PDs on scalp EEG ( 24 , 42 ). Recent neural network modeling with disinhibition of synaptic connections as a parameter, reliably reproduces GPDs ( 43 ), and altering the patterns of disinhibition or the time delay in the model simulates GPDs with varying morphology (polyphasic, multiple waves). This is interesting pathophysiology to consider, given the variation in the morphology of the PDs both between different patients ( Figures 1 – 3 , 5 , 6 ), and changes in PD morphology within the same patient, either spontaneously ( Figures 4 , 10 ) or with time and continued treatment ( Figure 5 ).…”

Section: Discussionmentioning

confidence: 99%

Periodic discharges in veterinary electroencephalography—A visual review

Knipe

Bush²,

Thomas³

et al. 2023

Front. Vet. Sci.

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First described in human EEG over 60 years ago, there are very few examples of periodic discharges in the veterinary literature. They are associated with a wide variety of etiologies, both intracranial and systemic, making interpretation challenging. Whether these patterns are indicative of ictal, interictal, or postictal activity is a matter of debate and may vary depending on the clinical features in an individual patient. Periodic discharges have a repeated waveform occurring at nearly regular intervals, with varying morphology of individual discharges from simple sharp waves or slow waves to more complex events. Amplitudes, frequencies, and morphologies of the discharges can fluctuate, occasionally evolving, or resolving over time. This study presents a visual review of several veterinary cases with periodic discharges on EEG similar to those described in human EEG, and discusses the current known pathophysiology of these discharges.

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“…In terms of optogenetic control for epilepsy, Rezvani-Ardakani et al ( 2020) designed the control method of fixed time integral super twisting sliding mode and tested the reliability on a pyramidal model. In macroscopic models, Shen et al (Shen et al 2022) created six smart optogenetic strategies for generalized periodic epileptiform discharges. These results facilitate our understanding of optogenetic stimulation in epilepsy and help to guide clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Examining the low-voltage fast seizure-onset and its response to optogenetic stimulation in a biophysical network model of the hippocampus

Zhang

Ma²,

Yu³

et al. 2023

Cogn Neurodyn

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Low-voltage fast (LVF) seizure-onset is one of the two frequently observed temporal lobe seizure-onset patterns. Depth electroencephalogram profile analysis illustrated that the peak amplitude of LVF onset was deep temporal areas, e.g., hippocampus. However, the specific dynamic transition mechanisms between normal hippocampal rhythmic activity and LVF seizure-onset remain unclear.Recently, the optogenetic approach to gain control over epileptic hyper-excitability both in vitro and in vivo has become a novel noninvasive modulation strategy. Here, we combined biophysical modeling to study LVF dynamics following changes in crucial physiological parameters, and investigated the potential optogenetic intervention mechanism for both excitatory and inhibitory control. In an Ammon's horn 3 (CA3) biophysical model with light-sensitive protein channelrhodopsin 2 (ChR2), we found that the cooperative effects of excessive extracellular potassium concentration of parvalbumin-positive (PV+) inhibitory interneurons and synaptic links could induce abundant types of discharges of the hippocampus, and lead to transitions from gamma oscillations to LVF seizure-onset. Simulations of optogenetic stimulation revealed that the LVF seizure-onset and morbid fast spiking could not be eliminated by targeting PV+ neurons, whereas the epileptic network was more sensitive to the excitatory control of principal neurons with strong optogenetic currents. We illustrate that in the epileptic hippocampal network, the trajectories of the normal and the seizure state are in close vicinity and optogenetic perturbations therefore may result in transitions. The network model system developed in this study represents a scientific instrument to disclose the underlying principles of LVF, to characterize the effects of optogenetic neuromodulation, and to guide future treatment for specific types of seizures.

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Transition dynamics and optogenetic controls of generalized periodic epileptiform discharges

Cited by 11 publications

References 49 publications

LncRNA Mir155hg Knockdown Attenuates Inflammation and Cognitive Impairment through regulating the NF-κΒ signaling pathway in a Rat Model of Status Epilepticus

LncRNA Mir155hg Knockdown Attenuates Inflammation and Cognitive Impairment through regulating the NF-κΒ signaling pathway in a Rat Model of Status Epilepticus

Periodic discharges in veterinary electroencephalography—A visual review

Examining the low-voltage fast seizure-onset and its response to optogenetic stimulation in a biophysical network model of the hippocampus

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