Transient splenial lesions of the corpus callosum in different stages of evolution

Öztoprak, İbrahim; Engin, Aynur; Gümüş, Cesur; Eğilmez, Hulusi; Öztoprak, Bilge

doi:10.1016/j.crad.2007.04.012

Cited by 9 publications

(9 citation statements)

References 29 publications

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“…[97] Epilepsy is characterized by a group of abnormal discharge of brain neurons in the central nervous system (CNS) function of sudden recurrent and transient disorder clinical syndrome. Öztoprak et al [5] had proposed a possible mechanism of RESLES in which the free water dispersion of the corpus callosum was decreased when the abnormal discharge of corpus callosum is disseminated. Seizures were not considered as an underlying cause of the lesions, although that possibility could not be excluded.…”

Section: Discussionmentioning

confidence: 99%

Reversible splenial lesion syndrome associated with lobar pneumonia

Wu²,

Qi³

et al. 2016

Medicine

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Background:Reversible splenial lesion syndrome (RESLES) is a rare clinico-radiological disorder with unclear pathophysiology. Clinically, RESLES is defined as reversible isolated splenial lesions in the corpus callosum, which can be readily identified by magnetic resonance imaging (MRI) and usually resolve completely over a period of time. RESLES could be typically triggered by infection, antiepileptic drugs (AEDs), poisoning, etc. More factors are increasingly recognized.Methods and results:We reported herein an 18-year-old female patient with lobar pneumonia who developed mental abnormalities during hospitalization. An isolated splenial lesion in the corpus callosum was found by head MRI and the lesion disappeared 15 days later. Based on her clinical manifestations and radiological findings, she was diagnosed with lobar pneumonia associated RESLES. We further summarize the up-to-date knowledge about the etiology, possible pathogenesis, clinical manifestations, radiological features, treatment, and prognosis of RESLES.Conclusion:This report contributes to the clinical understanding of RESLES which may present with mental abnormalities after infection. The characteristic imaging of reversible isolated splenial lesions in the corpus callosum was confirmed in this report. The clinical manifestations and lesions on MRI could disappear naturally after 1 month without special treatment.

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Section: Discussionmentioning

confidence: 99%

Reversible splenial lesion syndrome associated with lobar pneumonia

Wu²,

Qi³

et al. 2016

Medicine

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“…Transient splenial lesions (TSL) are seen in conditions with varied etiologies, including epilepsy, the usage as well as sudden withdrawal of antiepileptic drugs (AED), brain infarction, multiple sclerosis; cerebral trauma, neoplasm, adrenoleukodystrophy, AIDS dementia complex,[25–7] infections like influenza, measles, herpes, salmonella, mumps, adenovirus, varicella zoster, Legionnaires disease, rotavirus,[5] HIV, tubercular meningitis[3] and other conditions like hypoglycemia’[13] Marchiafava–Bignami syndrome, and hemolytic-uremic syndrome with encephalopathy. [8] Mild encephalitis/encephalopathy with a reversible isolated SCC lesion (MERS) is a recently described clinicoradiological syndrome with excellent prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Other postulated mechanisms are reversible extrapontine osmotic myelinolysis due to sodium and glucose imbalance and due to toxicity or hypersensitivity to AEDs or upon their withdrawal. [2312] TSL is also seen in the hemolytic-uremic syndrome with encephalopathy, where the possible mechanism is transient local edema caused by Escherichia coli verotoxin-induced microvascular angiopathy. [8]…”

Section: Discussionmentioning

confidence: 99%

“…[3] ADEM is characterized by multiple subcortical T2-hyperintense lesions that are nearly always asymmetric. The corpus callosum, whenever involved, also shows this asymmetry.…”

Section: Discussionmentioning

confidence: 99%

“…[1–4] These lesions are usually incidentally detected when imaging is done for encephalopathy/encephalitis or seizures, and the actual incidence might be more than what reports indicate. [3] Recognizing these lesions is important, both for the treating physician as well as the radiologist, as the differential diagnoses include a wide spectrum of conditions with varying clinical significance.…”

Section: Introductionmentioning

confidence: 99%

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Transient splenial lesion: Further experience with two cases

Singh

Gogoi

Vyas

et al. 2010

Indian Journal of Radiology and Imaging

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Transient splenial lesions (TSL) of the corpus callosum are uncommon radiologic findings that are seen in a number of clinical conditions with varied etiologies. They were first described a decade earlier in patients with epilepsy and hence were thought to be seizure or seizure therapy related. Subsequently, more cases were described by different observers in diseases with different etiologies, and the list is still increasing. Awareness of these lesions is necessary as they are an uncommon finding and have to be differentiated from other infective/noninfective causes. MRI is the imaging modality of choice as these lesions are not seen on routine noncontrast CT scan. The authors here describe two cases which showed TSL, with complete/partial resolution on follow-up scans. The authors also present a review of the literature.

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