Transient splenial lesion: Further experience with two cases

Singh, Paramjeet; Gogoi, Dhrubajyoti; Vyas, Sameer; Khandelwal, Niranjan

doi:10.4103/0971-3026.73531

Cited by 21 publications

(11 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transient reversible restricted diffusion within the splenium of the corpus callosum is a known radiological finding in various conditions that includes neonatal seizures, hemolytic-uremic syndrome with encephalopathy, neonatal hypoglycemia, antiepileptic drug therapy, epilepsy, viral encephalitis, demyelination disorders, and many other conditions. [567891011]…”

Section: Introductionmentioning

confidence: 99%

Restricted diffusion in the corpus callosum: A neuroradiological marker in hypoxic–ischemic encephalopathy

Kale

Joshi

Kelkar

2016

Indian Journal of Radiology and Imaging

View full text Add to dashboard Cite

Background:Restricted diffusion within the splenium of the corpus callosum has been described by other authors in various conditions, however, restricted diffusion in the entire corpus callosum or isolated involvement of the splenium, genu, or body has been infrequently reported on magnetic resonance imaging (MRI) in neonatal hypoxic–ischemic encephalopathy. We report a series of cases showing different patterns of involvement.Methods and Materials:Perinatal imaging with MRI including diffusion-weighted imaging was performed in 40 neonates with hypoxic–ischemic encephalopathy, including 11 premature neonates. Sixteen out of 40 patients demonstrated restricted diffusion within the corpus callosum. Out of 16 patients, 9 showed restricted diffusion in the entire corpus callosum, 4 had isolated splenium involvement, 2 had body and splenium signal abnormality, and 1 showed diffusion restriction only in the genu.Conclusions:Changes in the corpus callosum were also associated with more severe clinical presentation of encephalopathy. Restricted diffusion within the corpus callosum in infants with hypoxic–ischemic encephalopathy is often associated with extensive brain injury and appears to be an early neuroradiologic marker of adverse neurologic outcome.

show abstract

Section: Introductionmentioning

confidence: 99%

Restricted diffusion in the corpus callosum: A neuroradiological marker in hypoxic–ischemic encephalopathy

Kale

Joshi

Kelkar

2016

Indian Journal of Radiology and Imaging

View full text Add to dashboard Cite

show abstract

“…One of them (Case 5) demonstrated lesions in splenium of corpus callosum, a finding never reported before in either heroin or methadone intoxication. This finding may be a transient lesion of splenium and has been associated with various clinical conditions such as seizures, metabolic disturbances, infections, CNS malignancy, and drugs and toxins (antidepressants, antiepileptics, antipsychotics, chemotherapy agents, and pesticides) [15,[28][29][30][31][32][33][34][35][36][37][38]. We also had a single patient (case 8) who showed involvement of the globus pallidus and head of caudate nuclei.…”

Section: Discussionmentioning

confidence: 93%

Methadone-induced encephalopathy: a case series and literature review

et al. 2020

View full text Add to dashboard Cite

Background: Accidental ingestion or consumption of supra-therapeutic doses of methadone can result in neurological sequelae in humans. We aimed to determine the neurological deficits of methadone-poisoned patients admitted to a referral poisoning hospital using brain magnetic resonance (MR) and diffusion weighted (DW) imaging. Methods: In this retrospective study, brain MRIs of the patients admitted to our referral center due to methadone intoxication were reviewed. Methadone intoxication was confirmed based on history, congruent clinical presentation, and confirmatory urine analysis. Each patient had an MRI with Echo planar T1, T2, FLAIR, and DWI and apparent deficient coefficient (ADC) sequences without contrast media. Abnormalities were recorded and categorized based on their anatomic location and sequence. Results: Ten patients with abnormal MRI findings were identified. Eight had acute-and two had delayed-onset encephalopathy. Imaging findings included bilateral confluent or patchy T2 and FLAIR high signal intensity in cerebral white matter, cerebellar involvement, and bilateral occipito-parietal cortex diffusion restriction in DWI. Internal capsule involvement was identified in two patients while abnormality in globus pallidus and head of caudate nuclei were reported in another. Bilateral cerebral symmetrical confluent white matter signal abnormality with sparing of subcortical U-fibers on T2 and FLAIR sequences were observed in both patients with delayed-onset encephalopathy. Conclusions: Acute-and delayed-onset encephalopathies are two rare adverse events detected in methadoneintoxicated patients. Brain MRI findings can be helpful in detection of methadone-induced encephalopathy.

show abstract

“…One of them (Case 5) demonstrated lesions in splenium of corpus callosum, a finding never reported before in either heroin or methadone intoxication. This finding may be a transient lesion of splenium and has been associated with various clinical conditions such as seizures, metabolic disturbances, infections, CNS malignancy, and drugs and toxins (antidepressants, antiepileptics, antipsychotics, chemotherapy agents, and pesticides) (15,(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38). We also had a single patient (case 8) who showed involvement of the globus pallidus and head of caudate nuclei.…”

Section: Discussionmentioning

confidence: 97%

Methadone-Induced Encephalopathy: A Case Series and Literature Review

Haghighi-Morad

Naseri

Jamshidi

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Accidental ingestion or consumption of supra-therapeutic doses of methadone can result in neurological sequelae in humans. We aimed to determine the neurological deficits of methadone-poisoned patients admitted to a referral poisoning hospital using brain magnetic resonance (MR) and diffusion weighted (DW) imaging. Methods: In this retrospective study, brain MRIs of the patients admitted to our referral center due to methadone intoxication were reviewed. Methadone intoxication was confirmed based on history, congruent clinical presentation, and confirmatory urine analysis . Each patient had an MRI with Echo planar T1, T2, FLAIR, and DWI and apparent deficient coefficient (ADC) sequences without contrast media. Abnormalities were recorded and categorized based on their anatomic location and sequence. Results: Ten patients with abnormal MRI findings were identified. Eight had acute- and two had delayed-onset encephalopathy. Imaging findings included bilateral confluent or patchy T2 and FLAIR high signal intensity in cerebral white matter, cerebellar involvement, and bilateral occipito-parietal cortex diffusion restriction in DWI. Internal capsule involvement was identified in two patients while abnormality in globus pallidus and head of caudate nuclei were reported in another. Bilateral cerebral symmetrical confluent white matter signal abnormality with sparing of subcortical U-fibers on T2 and FLAIR sequences were observed in both patients with delayed-onset encephalopathy. Conclusions : Acute- and delayed-onset encephalopathies are two rare adverse events detected in methadone-intoxicated patients. Brain MRI findings can be helpful in detection of methadone-induced encephalopathy.

show abstract

Transient splenial lesion: Further experience with two cases

Cited by 21 publications

References 6 publications

Restricted diffusion in the corpus callosum: A neuroradiological marker in hypoxic–ischemic encephalopathy

Restricted diffusion in the corpus callosum: A neuroradiological marker in hypoxic–ischemic encephalopathy

Methadone-induced encephalopathy: a case series and literature review

Methadone-Induced Encephalopathy: A Case Series and Literature Review

Contact Info

Product

Resources

About