Transient receptor potential vanilloid-3 (TRPV3) channel induces dermal fibrosis via the TRPV3/TSLP/Smad2/3 pathways in dermal fibroblasts

Um, Ji Young; Kang, Seok Young; Kim, Hyun Ji; Chung, Bo Young; Park, Chun Wook; Kim, Hye One

doi:10.1016/j.jdermsci.2019.12.011

Cited by 31 publications

(26 citation statements)

References 30 publications

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“…Previous studies have demonstrated that protease-activated receptor 2 (PAR2), TRPV3, and TRPV4, are involved in the production of TSLP in keratinocytes under dry skin conditions ( 6 , 13 , 14 ). To confirm these observations, the primary culture of mouse keratinocytes was treated with PAR2, TRPV3, and TRPV4 agonists, and the levels of TSLP were measured.…”

Section: Resultsmentioning

confidence: 99%

Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus

Lee

Shim

2021

Front. Immunol.

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Dry skin is a symptom of skin barrier dysfunction that evokes pruritus; however, the cutaneous neuroimmune interactions underlying dry skin-induced pruritus remain unclear. Therefore, we aimed to elucidate the mechanisms underlying dry skin-induced pruritus. To this end, an acetone/ethanol/water (AEW)-induced mouse model of dry skin was used in this study. We observed that the production of thymic stromal lymphopoietin (TSLP) significantly increased in the keratinocytes of AEW mice. Importantly, treatment with an antagonist of transient receptor potential cation channel subfamily V member 4 (TRPV4), HC067047, ameliorated dry skin conditions in AEW mice. The symptoms of dry skin were significantly reduced in Trpv4 knockout (KO) mice following treatment with AEW. The increase in the intracellular calcium levels by TSLP in the dorsal root ganglia (DRG) of Trpv4 KO mice was also significantly attenuated. The spontaneous scratching bouts were significantly decreased in both the HC067047-treated and Trpv4 KO AEW mice. Importantly, the TSLP-dependent release of tryptase from the mast cells was significantly reduced in both the HC067047-treated mice and Trpv4 KO AEW mice. Notably, inhibition of the TSLP-induced signaling pathway in DRG selectively reduced the spontaneous scratching bouts in AEW mice. Overall, the results demonstrated that the cutaneous neuroimmune interactions of TSLP and TRPV4 play pivotal roles in dry skin-induced pruritus.

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Section: Resultsmentioning

confidence: 99%

Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus

Lee

Shim

2021

Front. Immunol.

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“…Mast cell releases histamine into post-burn lesion [38] Histamine Histamine appears to be a key initiator of impulses predominantly in the initial stages of healing after burn, but the role of histamine in post-burn itch is minimal [46] It helps keratinocyte produce inflammatory agents [34,37] Their receptors elevated more in the burn scar resulting in an increase of TSLP [8,44] Norepinephrine 5-Hydroxytryptamine(5-HT)…”

Section: Mast Cellmentioning

confidence: 99%

Post-Burn Pruritus

Chung

Kim

Jung

et al. 2020

IJMS

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Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient. Many potential treatments are available for pruritus but there is no consensus of the best single treatment yet. The precise mechanism of post-burn pruritus has not been elucidated, but it appears to have pruritogenic and neuropathic aspects. Clinically, post-burn pruritus tends to be intractable to conventional treatment but rather responds to neuroleptic agents, such as gabapentin and pregabalin. During wound healing, various neuropeptides secreted from the nerves of the skin control epidermal and vascular proliferation and connective tissue cells. When keratinocytes are activated by an itch-inducing substance, they secrete a variety of inflammatory substances that increase the susceptibility of the itch receptor. There are two mechanisms underlying post-burn neuropathic pruritus. The first one is peripheral sensitization. The second one is the intact nociceptor hypothesis. An effective treatment for post-burn pruritus will also be effective in other neuropathic and intractable itching. In this review, we summarized the interaction and mechanism of keratinocytes, immune cells, and nerve fibers related to post-burn pruritus.

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“…Moreover, activation of TRPV1 also mediates the expression of MMP-1 in natural-aging and heat-aging skin [ 2 ]. The activation of the TRPV3 channels regulates the dermal structure by reducing ECM production via the TRPV3/Thymic stromal lymphopoietin/Smad2/3 pathways in dermal fibroblasts [ 92 ]. In the process of photoaging, it is worth exploring whether the TGF-β pathway regulates TRPV3.…”

Section: Mechanisms Of Skin Photoagingmentioning

confidence: 99%

Boosting the Photoaged Skin: The Potential Role of Dietary Components

et al. 2021

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Skin photoaging is mainly induced by ultraviolet (UV) irradiation and its manifestations include dry skin, coarse wrinkle, irregular pigmentation, and loss of skin elasticity. Dietary supplementation of nutraceuticals with therapeutic and preventive effects against skin photoaging has recently received increasing attention. This article aims to review the research progress in the cellular and molecular mechanisms of UV-induced skin photoaging. Subsequently, the beneficial effects of dietary components on skin photoaging are discussed. The photoaging process and the underlying mechanisms are complex. Matrix metalloproteinases, transforming growth factors, skin adipose tissue, inflammation, oxidative stress, nuclear and mitochondrial DNA, telomeres, microRNA, advanced glycation end products, the hypothalamic–pituitary–adrenal axis, and transient receptor potential cation channel V are key regulators that drive the photoaging-associated changes in skin. Meanwhile, mounting evidence from animal models and clinical trials suggests that various food-derived components attenuate the development and symptoms of skin photoaging. The major mechanisms of these dietary components to alleviate skin photoaging include the maintenance of skin moisture and extracellular matrix content, regulation of specific signaling pathways involved in the synthesis and degradation of the extracellular matrix, and antioxidant capacity. Taken together, the ingestion of food-derived functional components could be an attractive strategy to prevent skin photoaging damage.

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Transient receptor potential vanilloid-3 (TRPV3) channel induces dermal fibrosis via the TRPV3/TSLP/Smad2/3 pathways in dermal fibroblasts

Cited by 31 publications

References 30 publications

Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus

Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus

Post-Burn Pruritus

Boosting the Photoaged Skin: The Potential Role of Dietary Components

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