“…TRPV1 is sensitive to several stimuli such as noxious, heat, low pH and several endogenous and exogenous molecules (Vriens et al, 2009). It is mainly involved in temperature sensing and nociception, but TRPV1 also participates in other cellular processes such as apoptosis (Contassot et al, 2004;Pan et al, 2013;Song et al, 2013), muscle contraction (Charrua et al, 2007;Matsumoto et al, 2009;Shimizu et al, 2007), autophagy (Farfariello et al, 2012;Li et al, 2014) and inflammation (Fernandes et al, 2012;Trevisani et al, 2004;Vigna et al, 2011). Some of the endogenous ligands of TRPV1, the endovanilloids, are the endocannabinoids anandamide (AEA) and N-arachidonoyldopamine (NADA), the oleoylethanolamide (OEA), protons, prostaglandins and lipoxygenase (LOX) or cytochrome P450 (CYP450) products (Vriens et al, 2009).…”