Transient receptor potential melastatin type 7 channels are involved in zinc-induced apoptosis in gastric cancer

Role of transient receptor potential melastatin type 7 channel in gastric cancer

“…In fact, TRPM7 is the only known zinc-permeable channel in the TRP channels,8, 11, 67 and the zinc permeability of TRPM7 is fourfold higher than its Ca 2+ permeability 11 . We found that the activation of TRPM7 channel augmented the Zn 2+ -induced AGS cell apoptosis, and that the TRPM7 overexpressed HEK293 cells increased Zn 2+ -induced cell damage 62 . Therefore, it appears that TRPM7 channel also represents a new target for physiological diseases in which Zn 2+ toxicity plays an important role.…”

“…Meyer and a well-known folk medicine and tonic), ginseng total saponin (GTS) 61 and ginsenosides Rg3 62 and Rd 63 were found to induce AGS cell death by blockading TRPM7 channel activity. Thus, these results suggested that TRPM7 channels are involved in GTS, ginsenoside Rg3, and Rd-induced gastric cancer cell apoptosis.…”