Role of transient receptor potential melastatin type 7 channel in gastric cancer

Kim, Byung Joo; Hong, Chansik

doi:10.1016/j.imr.2016.04.004

Cited by 16 publications

(16 citation statements)

References 85 publications

(111 reference statements)

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“…TRPM7 also plays a role in PC, but by increasing motility and thus the potential for metastasis, with its depletion causing a decrease in invasiveness through the HSP90α/uPA/MMP-2 proteolytic axis and targeted senescence, while results vary as to its role in proliferation[5,258-261,263-267]. TRPM7 has also been implicated as an oncogene in CRC[268] and GC[269-271]. Though a specific mechanism has not been proposed, TRPM2 over-expression has also been shown to reduce PC as well as GC patient survival by increasing invasiveness and pro-liferation[272,273].…”

Section: Calcium Channelsmentioning

confidence: 99%

Role of ion channels in gastrointestinal cancer

Anderson¹,

Cormier²,

Scott³

2019

WJG

129

103

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In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell. The functions of ion channels in the gastrointestinal (GI) tract influence a variety of cellular processes, many of which overlap with these hallmarks of cancer. In this review we focus on the roles of the calcium (Ca2+), sodium (Na+), potassium (K+), chloride (Cl-) and zinc (Zn2+) transporters in GI cancer, with a special emphasis on the roles of the KCNQ1 K+ channel and CFTR Cl- channel in colorectal cancer (CRC). Ca2+ is a ubiquitous second messenger, serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle, apoptosis, and migration. Various members of the TRP superfamily, including TRPM8, TRPM7, TRPM6 and TRPM2, have been implicated in GI cancers, especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon cancer. Voltage-gated sodium channels (VGSCs) are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle cells. The VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC samples. Studies have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer progression. Zn2+ transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers, in particular, ZIP4 up-regulation in pancreatic cancer (PC). More than 70 K+ channel genes, clustered in four families, are found expressed in the GI tract, where they regulate a range of cellular processes, including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal tract. Several distinct types of K+ channels are found dysregulated in the GI tract. Notable are hERG1 upregulation in PC, gastric cancer (GC) and CRC, leading to enhanced cancer angiogenesis and invasion, and KCNQ1 down-regulation in CRC, where KCNQ1 expression is associated with enhanced disease-free survival in stage II, III, and IV disease. Cl- channels are critical for a range of cellular and tissue processes in the GI tract, especially fluid balance in the colon. Most notable is CFTR, whose deficiency leads to mucus blockage, microbial dysbiosis and inflammation in the intestinal tract. CFTR is a tumor suppressor in several GI cancers. Cystic fibrosis patients are at a significant risk for CRC and low levels of CFTR expression are associated with poor overall disease-free survival in sporadic CRC. Two other classes of chloride channels that are dysregulated in GI cancers are the chloride intracellular channels (CLIC1, 3 & 4) and the chloride channel accessory proteins (CLCA1,2,4). CLIC1 & 4 are upregulated in PC, GC, gallbladder cancer, and CRC, while the CLCA proteins have been reported to be down-regulated in CRC. In summary, it is clear, from the diverse influences of ion channels, that their aberrant expression and/or activity c...

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Section: Calcium Channelsmentioning

confidence: 99%

Role of ion channels in gastrointestinal cancer

Anderson¹,

Cormier²,

Scott³

2019

WJG

129

103

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“…TRPM7 channels have been shown to be predominant actors in the growth and survival of human gastric adenocarcinoma cells. Kim et al [ 76 ] noticed an abundant expression of TRPM7 messenger RNA and protein in AGS gastric cancer cells, the most commonly used line of human gastric adenocarcinoma cells. The blocking of TRPM7 channels with La 3+ and 2-APB, or silencing TRPM7 expression with siRNA, inhibited the growth and survival of these cells.…”

Section: Trpm Channels In Cancermentioning

confidence: 99%

“…The blocking of TRPM7 channels with La 3+ and 2-APB, or silencing TRPM7 expression with siRNA, inhibited the growth and survival of these cells. Kim et al [ 76 ] later found that ginsenoside Rg3 inhibits the growth and survival of gastric cancer cells by blocking TRPM7 channel activity.…”

Section: Trpm Channels In Cancermentioning

confidence: 99%

TRPM Family Channels in Cancer

et al. 2018

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Members of the TRPM (“Melastatin”) family fall into the subclass of the TRP channels having varying permeability to Ca2+ and Mg2+, with three members of the TRPM family being chanzymes, which contain C-terminal enzyme domains. The role of different TRPM members has been shown in various cancers such as prostate cancer for mostly TRPM8 and TRPM2, breast cancer for mostly TRPM2 and TRPM7, and pancreatic cancer for TRPM2/7/8 channels. The role of TRPM5 channels has been shown in lung cancer, TRPM1 in melanoma, and TRPM4 channel in prostate cancer as well. Thus, the TRPM family of channels may represent an appealing target for the anticancer therapy.

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“…Accumulating evidence has indicated that TRP members were expressed abundantly in cancer cells and closely related to tumor progression. Kim et al reported that TRPM7 played a key role in the growth and survival of gastric cancer cells 56 . Elevated expression of TRPC5 protein is associated with the drug resistance of breast cancer cells 57 , and promotes colon cancer metastasis via the hypoxia-inducible factor 1-alpha/Twist (HIF-1α/Twist) signaling pathway 58 .…”

Section: Trp Superfamilymentioning

confidence: 99%

Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment

Huang

Ding

et al. 2019

Cell Death Dis

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The transient receptor potential ion-channel superfamily consists of nonselective cation channels located mostly on the plasma membranes of numerous animal cell types, which are closely related to sensory information transmission (e.g., vision, pain, and temperature perception), as well as regulation of intracellular Ca 2+ balance and physiological activities of growth and development. Transient receptor potential ion channel subfamily V (TRPV) is one of the largest and most diverse subfamilies, including TRPV1-TRPV6 involved in the regulation of a variety of cellular functions. TRPV4 can be activated by various physical and chemical stimuli, such as heat, mechanical force, and phorbol ester derivatives participating in the maintenance of normal cellular functions. In recent years, the roles of TRPV4 in cell proliferation, differentiation, apoptosis, and migration have been extensively studied. Its abnormal expression has also been closely related to the onset and progression of multiple tumors, so TRPV4 may be a target for cancer diagnosis and treatment. In this review, we focused on the latest studies concerning the role of TRPV4 in tumorigenesis and the therapeutic potential. As evidenced by the effects on cancerogenesis, TRPV4 is a potential target for anticancer therapy. Facts 1. TRPV4 is a broadly expressed, nonselective calcium permeant cation channel that perform an important role in regulating the Ca 2+ influx in the cells in which they are expressed. 2. TRPV4 is a thermosensor, activated by temperatures greater than 24-27°C, also can be activated by osmotic, mechanical, and chemical cues. 3. TRPV4 is constitutively expressed and capable of spontaneous activity in the absence of agonist stimulation, which suggests that it serves important physiological functions. Open questions 1. What is the underlying cause of TRPV4 expression levels in different types of cancer? 2. Whether it is possible to lower the toxicity and highefficiency TRPV4 inhibitors from natural products to treat various diseases? 3. How to inhibit the development of cancer by targeting TRPV4 of tumor cells without affecting the function of normal cells?

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Role of transient receptor potential melastatin type 7 channel in gastric cancer

Cited by 16 publications

References 85 publications

Role of ion channels in gastrointestinal cancer

Role of ion channels in gastrointestinal cancer

TRPM Family Channels in Cancer

Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment

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