Transient Prosopagnosia With Right Temporal Astrocytoma

Anderson, Craig; Woodcock, Jonathan H.; Filley, Christopher M.

doi:10.1176/appi.neuropsych.15070169

Cited by 2 publications

(3 citation statements)

References 10 publications

(10 reference statements)

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“…The first group includes prosopagnosia caused directly due to tumors involving the right temporal lobe, for example, astrocytoma or lepto-meningeal metastases. 5 The second includes a few patients who did not have prosopagnosia at presentation, but developed prosopagnosia as a transient symptom following treatment of different pathologies involving the right temporo-occipital lobe; that is, resection of a low-grade glioma, arteriovenous malformation treatment, or intrathecal chemotherapy for leptomeningeal metastases involving this region. [6][7][8] The third group of papers, interestingly, includes tumors outside the CNS.…”

Section: Discussionmentioning

confidence: 99%

Pearls & Oy-sters: Isolated prosopagnosia as the presenting complaint in glioblastoma

Das

Burton

2019

Neurology

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Prosopagnosia localizes to the fusiform gyrus in the medial temporal lobe and occurs from bilateral lesions or less frequently from unilateral lesions involving the right side alone. c Commonly reported lesions resulting in prosopagnosia include strokes and seizures involving the above regions, while tumors are a rarely reported cause. c Facial recognition is a more complex process than previously thought. Core face recognition network in the brain includes the occipital face area, the fusiform face area, and the face-selective posterior superior temporal sulcus.

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Section: Discussionmentioning

confidence: 99%

Pearls & Oy-sters: Isolated prosopagnosia as the presenting complaint in glioblastoma

Das

Burton

2019

Neurology

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“…[3] Cerebrovascular disease, epilepsy, trauma, brain tumor, encephalitis, and carbon monoxide poisoning have been reported as the causes of acquired prosopagnosia. [1,2,[4][5][6][7]9,11] With regard to brain tumors, lesions in the right lingual and fusiform gyrus are generally considered to be responsible for prosopagnosia. [8] For lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation, tyrosine kinase inhibitors (TKIs) have become the first-line drugs of choice.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment of transient prosopagnosia with a tyrosine kinase inhibitor in a case of brain metastasis from EGFR-mutated lung adenocarcinoma

Soyama

Matsuda

Hontsu

et al. 2022

Surgical Neurology International

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Background: Prosopagnosia is a rare form of apraxia, in which a person has normal memory and vision, but has impaired cognition of human faces that are manifested through symptoms such as not being able to recognize the face of a familiar person, one has known or not being able to remember the face of a person. Here, we report the case of a patient with transient prosopagnosia associated with brain metastasis from epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma who was treated with tyrosine kinase inhibitors (TKIs). Case Description: A 52-year-old right-handed man with lung adenocarcinoma was introduced to our department because brain metastasis. On admission, he complained that he could not recognize his wife’s face, but he could recall her face based on her voice. MRI revealed a right temporo-occipital enhancing lesion with perifocal edema and dissemination that were indicative of brain metastasis from lung adenocarcinoma. Two weeks after open biopsy, he was started on TKI therapy with osimertinib at a dosage of 80 mg/day. An MRI scan taken 1 month later revealed shrinkage of the metastasis. In addition, he had recovered from transient prosopagnosia and returned to normal life. Conclusion: In this study, the TKI osimertinib was administered to a patient with brain metastasis of EGFR-mutated lung adenocarcinoma who presented with prosopagnosia, and the patient’s lesion shrunk and his symptoms were reversed with this treatment.

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Transient Prosopagnosia With Right Temporal Astrocytoma

Cited by 2 publications

References 10 publications

Pearls & Oy-sters: Isolated prosopagnosia as the presenting complaint in glioblastoma

Pearls & Oy-sters: Isolated prosopagnosia as the presenting complaint in glioblastoma

Treatment of transient prosopagnosia with a tyrosine kinase inhibitor in a case of brain metastasis from EGFR-mutated lung adenocarcinoma

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