Transient Myeloproliferative Disorder of the Down Type in the Normal Newborn

Transient myeloproliferative disorder with vesiculopustular eruption: Early smear is useful for quick diagnosis

“…In rare cases, TMD is accompanied by vesiculopustular eruption. [3][4][5][6][7][8][9][10][11][12][13] We report an infant with DS showing TMD and skin lesions, in whom genetic analyses detected a somatic mutation of GATA-1 197G[T(Glu295Stop).…”

Case 19-2003

“…Transient myeloproliferative disorder, or transient leukemia of infancy, is usually diagnosed in the first weeks of life and is always associated with Down's syndrome, or trisomy 21. [11][12][13][14][15][20][21][22][23][24] Infants with this disorder have leukocytosis, often with a greater percentage of blasts in the peripheral blood than in the bone marrow. Hepatosplenomegaly, pericardial or pleural effusions, and liver disease are common.…”

Spontaneous remission of congenital acute nonlymphoblastic leukemia with normal karyotype in twins

“…The spontaneous remission of the TMD has been directly associated with the presence of one extra chromosome 21 in the leukemic cell. Spontaneous remission of congenital leukemia in an otherwise karyotypically normal newborn has also been reported [6][7][8]. More commonly, frequent karyotypic abnormalities are found in this group of patients, including t(8;16), t(1;14), t(9;11), t(5;11), and chromosome 11q23 structural defects [9][10][11][12].…”