Transient myelofibrosis with autoimmune pancytopenia: a case report

Abstract

Myelofibrosis associated with mild myelodysplasia and pancytopenia can have a benign evolution in infants and young children.

Pediatric autoimmune myelofibrosis: Experience from a large pediatric tertiary care center

“…PAIMF is a rare entity, distinct from pediatric myelofibrosis. Eleven PAIMF are documented from 1983 to 2020, [6][7][8][9][10][11][12][13][14][15][16] with three children under 1 year of age. 12,13,15 Most cases are older female adolescents with concurrent SLE.…”

“…Eleven PAIMF are documented from 1983 to 2020, [6][7][8][9][10][11][12][13][14][15][16] with three children under 1 year of age. 12,13,15 Most cases are older female adolescents with concurrent SLE. 8 No patients in this cohort had SLE, suggesting AIMF occurs outside of SLE in children.…”

“…Previously reported therapies include corticosteroids with 64% required multiple agents or repeated treatment courses. 7,8,[11][12][13]15,16 Unless there is an underlying disorder with a known targeted therapy, we suggest steroids upfront, with the addition of rituximab in severe cases or those where steroids cannot be weaned. In our experience, patients may require prolonged steroid courses.…”

Autoimmune myelofibrosis as the first manifestation of human immunodeficiency virus infection in an infant

“…Most reported cases are secondary diagnosis that occurs after acute leukemias, metastatic embryonal cancers, or congenital bone marrow failure syndromes [1]. Other reports were associated with autoimmune diseases [2,3], vitamin D deficiency rickets [4], or congenital anomalies or Down syndrome [5,6]. A rapidly fatal form affecting multiple siblings in two families has also been reported [7,8].…”