Autoimmune myelofibrosis as the first manifestation of human immunodeficiency virus infection in an infant

Lee, Acw; Fong, Chee Meng

doi:10.1007/s00277-011-1329-6

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…Myelofibrosis in the pediatric age group is uncommon, and the cases reported are secondary to hematological malignancies, bone marrow failure syndromes, metastatic neoplasms, vitamin D deficiency rickets, auto-immune diseases, and occasionally idiopathic. Myelofibrosis secondary to HIV is extremely rare and could be due to immunological abnormalities associated with HIV [17]. In our study, myelofibrosis was noted in 7 (35%) cases, of which 1 had multiple bone marrow epithelioid granulomas, 1 had infiltration by Burkitt lymphoma, and 5 cases did not reveal any specific pathology except for megakaryocyte clustering with dysplasia and reactive changes.…”

Section: Discussionmentioning

confidence: 49%

Bone marrow examination of HIV-infected children in HAART era reveals a spectrum of abnormalities: a study from single tertiary care center of North India

Sharma

Sachdeva

et al. 2021

J Hematopathol

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Pediatric HIV is a significant contributor to childhood morbidity and mortality. As HIV infects bone marrow CD34-positive progenitor cells, the hematological abnormalities are well-expected. The viral load is much higher in children predisposing them to opportunistic infections and hematopoietic malignancies. The present study aimed to determine the spectrum of hematological abnormalities that may yield clinically useful information in HIV-infected children. This was a retrospective study of 19 HIV-infected children who underwent bone marrow examination. Overall, 20 peripheral blood and bone marrow samples were analyzed for morphological changes in all hematopoietic lineages. Immunohistochemistry was performed on trephine biopsy sections for evaluation of B and T cells and cytomegalovirus inclusions. Anemia was the most common cytopenia (95%), followed by thrombocytopenia (45%) and leukopenia (40%). Myelodysplasia was noted in 70% of cases. Dysmegakaryopoiesis was predominant in 65% of cases, while dyserythropoiesis was noted in 25% of cases. Hemophagocytosis and reactive cellular changes were noted in 20% of cases each. Benign lymphoid aggregates and granulomatous inflammation were observed in 15% and 10% of cases, respectively. Significant myelofibrosis was found in 35% of cases. One case showed infiltration by Burkitt lymphoma. Parvoviral inclusions were identified in 1 case. An interstitial increase and aggregates of CD8 + T cells and reduced CD4 + T cells were noted. CD20 + B cells were normal to mildly increased in the bone marrow. Bone marrow examination provides clinically significant information in pediatric HIV revealing the underlying cause of hematopoietic abnormalities and allows the exclusion of major hematological neoplasms.

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Section: Discussionmentioning

confidence: 49%

Bone marrow examination of HIV-infected children in HAART era reveals a spectrum of abnormalities: a study from single tertiary care center of North India

Sharma

Sachdeva

et al. 2021

J Hematopathol

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“…PAIMF is a rare entity, distinct from pediatric myelofibrosis. Eleven PAIMF are documented from 1983 to 2020, [6][7][8][9][10][11][12][13][14][15][16] with three children under 1 year of age. 12,13,15 Most cases are older female adolescents with concurrent SLE.…”

Section: Discussionmentioning

confidence: 99%

“…Eleven PAIMF are documented from 1983 to 2020, [6][7][8][9][10][11][12][13][14][15][16] with three children under 1 year of age. 12,13,15 Most cases are older female adolescents with concurrent SLE. 8 No patients in this cohort had SLE, suggesting AIMF occurs outside of SLE in children.…”

Section: Discussionmentioning

confidence: 99%

Pediatric autoimmune myelofibrosis: Experience from a large pediatric tertiary care center

Kim

Curry

Wiszniewska

et al. 2023

Pediatric Blood & Cancer

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Autoimmune myelofibrosis (AIMF) is a rare disorder characterized by cytopenias and autoimmunity, with characteristic bone marrow findings that include lymphocytic infiltration and fibrosis. AIMF is described predominantly in adult populations who have systemic lupus erythematosis (SLE), with scant pediatric cases described mainly in older adolescents with SLE. Here, we described the largest single‐center pediatric experience of pediatric autoimmune myelofibrosis (PAIMF) series, demonstrating both similarities and distinctions from the adult experience. Patients overall respond well to steroid therapy, but these patients were significantly younger, infrequently carried a diagnosis of SLE, and causative genetic lesions were identified in many cases.

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“…Diseases such as systemic lupus erythematous (SLE), scleroderma and Sjögren's syndrome are the main disorders described in association with secondary AIMF. 6 , 7 AIMF has also been described in association with HIV infection 9 but not with HTLV infection. The differentiation between AIMF and the MPN-related myelofibrosis is imperative once these disorders have different management and prognoses.…”

Section: Discussionmentioning

confidence: 99%

Hematological manifestations of human T lymphotropic virus type 1 infection: a possible association with autoimmune myelofibrosis

Ciminelli

Melo

Copin

et al. 2016

Revista Brasileira de Hematologia e Hemoterapia

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Autoimmune myelofibrosis as the first manifestation of human immunodeficiency virus infection in an infant

Cited by 6 publications

References 11 publications

Bone marrow examination of HIV-infected children in HAART era reveals a spectrum of abnormalities: a study from single tertiary care center of North India

Bone marrow examination of HIV-infected children in HAART era reveals a spectrum of abnormalities: a study from single tertiary care center of North India

Pediatric autoimmune myelofibrosis: Experience from a large pediatric tertiary care center

Hematological manifestations of human T lymphotropic virus type 1 infection: a possible association with autoimmune myelofibrosis

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