Transient increase of fractional anisotropy in reversible vasogenic edema

Kimura-Ohba, Shihoko; Yang, Yi; Thompson, Jeffrey; Kimura, Tomonori; Salayandia, Victor M; Cossé, Melissa; Yang, Yirong; Sillerud, Laurel O.; Rosenberg, Gary A.

doi:10.1177/0271678x16630556

Cited by 30 publications

(35 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is common to report asymmetry or group difference in bundle volume (Catani et al, 2007;Chenot et al, 2019;Song et al, 2014), diffusion values within the bundle of interest (average fractional anisotropy, mean diffusivity, etc.) (De Erausquin & Alba-Ferrara, 2013;Kimura-Ohba et al, 2016;Ling et al, 2012;Mole et al, 2016) or values along the bundle (called profilometry and tractometry) (Cousineau et al, 2017;Dayan et al, 2016;Yeatman, Dougherty, Myall, Wandell, & Feldman, 2012;Yeatman, Richie-Halford, Smith, Keshavan, & Rokem, 2018). Spatial distribution of cortical terminations of streamlines can help to identify cortical regions with underlying WM connections affected by a condition (Behrens et al, 2003;Donahue et al, 2016;Johansen-Berg et al, 2004;Mars et al, 2011;Rushworth, Behrens, & Johansen-Berg, 2005).…”

Section: Bundle Segmentationmentioning

confidence: 99%

Tractostorm: The what, why, and how of tractography dissection reproducibility

Rheault

Benedictis

Daducci

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called “virtual dissection.” Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion that if the field of dMRI tractography wants to be taken seriously as a widespread clinical tool, it is imperative to harmonize WM bundle segmentations and develop protocols aimed to be used in clinical settings. The EADC‐ADNI Harmonized Hippocampal Protocol achieved such standardization through a series of steps that must be reproduced for every WM bundle. This article is an observation of the problematic. A specific bundle segmentation protocol was used in order to provide a real‐life example, but the contribution of this article is to discuss the need for reproducibility and standardized protocol, as for any measurement tool. This study required the participation of 11 experts and 13 nonexperts in neuroanatomy and “virtual dissection” across various laboratories and hospitals. Intra‐rater agreement (Dice score) was approximately 0.77, while inter‐rater was approximately 0.65. The protocol provided to participants was not necessarily optimal, but its design mimics, in essence, what will be required in future protocols. Reporting tractometry results such as average fractional anisotropy, volume or streamline count of a particular bundle without a sufficient reproducibility score could make the analysis and interpretations more difficult. Coordinated efforts by the diffusion MRI tractography community are needed to quantify and account for reproducibility of WM bundle extraction protocols in this era of open and collaborative science.

show abstract

Section: Bundle Segmentationmentioning

confidence: 99%

Tractostorm: The what, why, and how of tractography dissection reproducibility

Rheault

Benedictis

Daducci

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…33 Altogether, while certain aspects of the pathophysiology may overlap, our data do not support SHRSP on high-salt diet as a translational model for chronic hypertensive small vessel disease or vascular dementia as has been endorsed in the past. [11][12][13][14][15][16]34 The tissue hallmarks of the disease process in SHRSP on high-salt diet were BBB disruption (i.e. IgG leakage, and elevated T2 and ADC on MRI) and microbleeds, 35,36 both of which are neuroimaging features of PRES as well.…”

Section: Discussionmentioning

confidence: 99%

“…8 Imaging studies suggested that cerebral lesions in SHRSP on high-salt diet developed rather acutely and resembled vasogenic edema. 9,10 The SHRSP on high-salt diet has also been proposed as a model of vascular cognitive impairment, [11][12][13][14][15][16] a chronic brain disease linked to age, hypertension and diabetes. 17,18 In humans, MRI findings of acute and chronic hypertension differ significantly.…”

Section: Introductionmentioning

confidence: 99%

Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet

Herisson

Zhou

Mawet

et al. 2018

J Cereb Blood Flow Metab

View full text Add to dashboard Cite

Stroke-prone spontaneously hypertensive rats (SHRSP) on high-salt diet are characterized by extremely high arterial pressures, and have been endorsed as a model for hypertensive small vessel disease and vascular cognitive impairment. However, rapidly developing malignant hypertension is a well-known cause of posterior reversible encephalopathy syndrome (PRES) in humans, associated with acute neurological deficits, seizures, vasogenic cerebral edema and microhemorrhages. In this study, we aimed to examine the overlap between human PRES and SHRSP on high-salt diet. In SHRSP, arterial blood pressure progressively increased after the onset of high-salt diet and seizure-like signs emerged within three to five weeks. MRI revealed progressive T2-hyperintense lesions suggestive of vasogenic edema predominantly in the cortical watershed and white matter regions. Histopathology confirmed severe blood-brain barrier disruption, white matter vacuolization and microbleeds that were more severe posteriorly. Hematological data suggested a thrombotic microangiopathy as a potential underlying mechanism. Unilateral common carotid artery occlusion protected the ipsilateral hemisphere from neuropathological abnormalities. Notably, all MRI and histopathological abnormalities were acutely reversible upon switching to regular diet and starting antihypertensive treatment. Altogether our data suggest that SHRSP on high-salt diet recapitulates the neurological, histopathological and imaging features of human PRES rather than chronic progressive small vessel disease.

show abstract

“…Higher AD in white matter tracts indicates greater water diffusion along the axons, which is typically observed during acute inflammation, with increased cytokines (Singh et al 2016) and fluid leaking into myelin space causing axonal swelling (Kimura-Ohba et al 2016), or from loss of axonal fibers (Hikishima et al 2015). Neuroinflammation, including microglial and astroglial activation (Thomas et al 2004; Borgmann and Ghorpade 2015), was shown in Meth-induced brain injury (Yu et al 2015).…”

Section: Discussionmentioning

confidence: 99%

Brain Microstructure and Impulsivity Differ between Current and Past Methamphetamine Users

Andres

Ernst

Oishi

et al. 2016

J Neuroimmune Pharmacol

View full text Add to dashboard Cite

Methamphetamine (Meth) use disorder continues to be highly prevalent worldwide. Meth users have higher impulsivity and brain abnormalities that may be different between current and past Meth users. The current study assessed impulsivity and depressive symptoms in 94 participants (27 current Meth users, 32 past Meth users and 35 non-drug user controls). Additionally, brain microstructure was assessed using diffusion tensor imaging (DTI); fractional anisotropy (FA) and mean diffusivity (MD) were assessed in the striatum, and FA, MD, radial and axial diffusivity were quantified in five white matter structures using DtiStudio.Across the three subject groups, current users had the highest self-reported impulsivity scores, while both Meth user groups had larger striatal structures than the controls. Past Meth users had the highest FA and lowest MD in the striatum, which is likely due to greater magnetic susceptibility from higher iron content and greater dendritic spine density. In white matter tracts, current Meth users had higher AD than past users, indicating greater water diffusion along the axons, and suggesting inflammation with axonal swelling. In contrast, past users had the lowest AD, indicating more restricted diffusion, which might have resulted from reactive gliosis. Although current Meth users had greater impulsivity than past users, the brain microstructural abnormalities showed differences that may reflect different stages of neuroinflammation or iron-induced neurodegeneration. Combining current and past Meth users may lead to greater variability in studies of Meth users. Longitudinal studies are needed to further evaluate the relationship between recency of Meth use and brain microstructure.

show abstract

Transient increase of fractional anisotropy in reversible vasogenic edema

Cited by 30 publications

References 44 publications

Tractostorm: The what, why, and how of tractography dissection reproducibility

Tractostorm: The what, why, and how of tractography dissection reproducibility

Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet

Brain Microstructure and Impulsivity Differ between Current and Past Methamphetamine Users

Contact Info

Product

Resources

About