Combined amide and amine effects dominated the MTR changes after global ischemia, indicating that MTR is predominantly pH-sensitive and suitable for detecting tissue acidosis following acute stroke.

The proposed ratiometric approach extended the iopamidol pH detection range, enabling the renal pH mapping in vivo, which is promising for pH imaging studies at sub-high or low fields with potential clinical applicability. Magn Reson Med 79:1553-1558, 2018. © 2017 International Society for Magnetic Resonance in Medicine.