Transient Global Amnesia - Risk Factors and Putative Background

Waliszewska‐Prosół, Marta; Nowakowska-Kotas, Marta; Bladowska, Joanna; Papier, Paulina; Budrewićz, Sławomir; Pokryszko−Dragan, Anna

doi:10.4103/0028-3886.288979

Cited by 11 publications

(19 citation statements)

References 31 publications

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“…The current study showed a significant age difference between TGA-patients and AIS-patients. The mean age of our TGA population was in line with the mean age of many other reported study populations ( 14 , 20 , 21 , 31 , 33 , 36 ). Furthermore, the age of our AIS-patients was consistent with other large stroke cohorts ( 37 , 38 ) in previous studies.…”

Section: Other Risk Factorssupporting

confidence: 91%

“…Regarding microangiopathy, the study by Enzinger et al showed no significant difference in the extent of microangiopathy between TGA-patients and HC ( 16 ). Another study showed a similar prevalence of cerebral microangiopathy compared to our study ( 33 ).…”

Section: Hypertension and Cerebral Microangiopathysupporting

confidence: 89%

“…Although, other studies reported also a female predominance ( 3 , 14 , 18 , 34 ), a meta-analysis revealed no significant gender difference (46.4% men and 53.6% women; χ 2 = 0.48, p = 0.49) between the 1,333 patients collected from 52 published case series ( n = 91) and 34 published group studies ( n = 1,171) ( 34 ). More recent studies published after this meta-analysis also reported a female predominance ( 14 , 33 ). A possible explanation could be the frequent diagnosis of stroke mimics in women despite similar symptoms compared to men ( 35 ).…”

Section: Other Risk Factorssupporting

confidence: 53%

“…In contrast, in our study we analyzed blood pressure values in the initial phase after symptom onset. The only study which reported elevated SBP values in the acute phase was by Nedelmann et al (32). In this study, 21 of 22 patients with TGA showed elevated mean pressure 3 h after onset of symptoms (180.9/98.3 mmHg), and one-third of patients had SPB values above 200 mmHg.…”

Section: Hypertension and Cerebral Microangiopathymentioning

confidence: 59%

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Transient Global Amnesia (TGA): Influence of Acute Hypertension in Patients Not Adapted to Chronic Hypertension

et al. 2021

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Objective: Transient global amnesia (TGA) is defined by an acute memory disturbance of unclear etiology for a period of <24 h. Several studies showed differences in vascular risk factors between TGA compared to transient ischemic attack (TIA) or healthy controls with varying results. This retrospective and cross-sectional study compares the cardiovascular risk profile of TGA patients with that of acute stroke patients.Methods: Cardiovascular risk profile and MR imaging of 277 TGA patients was retrospectively analyzed and compared to 216 acute ischemic stroke patients (26% TIA).Results: TGA patients were significantly younger and predominantly female compared to stroke patients. A total of 90.6% of TGA patients underwent MRI, and 53% of those showed hippocampal diffusion-weighted imaging (DWI) lesions. Scores for cerebral microangiopathy were lower in TGA patients compared to stroke patients. After statistical correction for age, TGA patients had higher systolic and diastolic blood pressure, higher cholesterol levels, lower HbA1c, as well as blood glucose levels, and lower CHA2DS2-VASc scores. Stroke patients initially displayed higher CRP levels than TIA and TGA patients. TGA patients without DWI lesions were older and showed higher CHA2DS2-VASc scores compared to TGA patients with DWI lesions.Conclusion: This study revealed significant differences between TGA and stroke patients in regard to the cardiovascular risk profile. Our main findings show a strong association between acute hypertensive peaks and TGA in patients not adapted to chronic hypertension, indicating a vascular cause of the disease.

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Section: Other Risk Factorssupporting

confidence: 91%

Section: Hypertension and Cerebral Microangiopathysupporting

confidence: 89%

Section: Other Risk Factorssupporting

confidence: 53%

Section: Hypertension and Cerebral Microangiopathymentioning

confidence: 59%

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Transient Global Amnesia (TGA): Influence of Acute Hypertension in Patients Not Adapted to Chronic Hypertension

et al. 2021

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“…Interesting conclusions were provided by a recent study characterizing a group of 56 patients with transient global amnesia (TGA), which appears to be a disorder from the spectrum of vascular diseases and not, as had been previously thought, epileptic. Autoimmune thyroiditis was the only comorbidity in 17.9% of patients [ 101 ]. TGA is associated with disturbance of microcirculation in the hippocampus and in one patient with HE, MRI revealed bilateral hippocampal or thalamic lesions [ 102 ].…”

Section: Resultsmentioning

confidence: 99%

Hashimoto Encephalopathy—Still More Questions than Answers

Waliszewska‐Prosół

Ejma

2022

Cells

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The normal function of the nervous system is conditioned by the undisturbed function of the thyroid gland and its hormones. Comprehensive clinical manifestations, including neurological disorders in Hashimoto’s thyroiditis, have long been understood and, in recent years, attention has been paid to neurological symptoms in euthyroid patients. Hashimoto encephalopathy is a controversial and poorly understood disease entity and the pathogenesis of the condition remains unclear. We still derive our understanding of this condition from case reports, but on the basis of these, a clear clinical picture of this entity can be proposed. Based on a review of the recent literature, the authors present the current view on the subject, discuss controversies and questions that still remain unanswered, as well as ongoing research in this area and the results of our own work in patients with Hashimoto’s thyroiditis.

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