Transient Global Amnesia in a Collegiate Baseball Player with Type I Diabetes Mellitus: A Case Report

Gravlee, Jocelyn R.; Barrett, J.

doi:10.4085/1062-6050-46.3.319

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…Mild to moderate traumatic brain injury was capable of producing prolonged spatial memory deficit in rats without evidence of neuronal death [ 3 ]. Diabetes has been linked to memory impairment in rats [ 6 ] and humans [ 7 ]. On the other hand, hypoglycemia secondary to insulin overdose can also cause hippocampal injury which could result in anterograde amnesia [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

Giribabu

Srinivasarao

Rekha

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role of C. asiatica on the hippocampus in diabetes. Methods. Streptozotocin- (STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C. asiatica leaf aqueous extract for four consecutive weeks. Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na+/K+-, Ca2+- and Mg2+-ATPases activity levels. Levels of the markers of inflammation (tumor necrosis factor, TNF-α; interleukin, IL-6; and interleukin, IL-1β) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined. The hippocampal sections were visualized for histopathological changes. Results. Administration of C. asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus. Lesser signs of histopathological changes were observed in the hippocampus of C. asiatica leaf aqueous extract treated diabetic rats. Conclusions. C. asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition.

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Section: Introductionmentioning

confidence: 99%

Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

Giribabu

Srinivasarao

Rekha

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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“…9 It is suggested that the spreading depression theory could explain the changes noted in TGA and venous congestion with ischemia in the memory regions of the brain. 10 Recent work by Strupp et al, using functional MRI techniques showed changes in both the mesial temporal lobes in these patients, and the signal abnormalities reflected changes along the pattern seen in spreading depression rather than in focal ischemia. 11 The occurrence of both TGA and migraines simultaneously would further support the spreading cortical depression theory as the basic pathophysiologic phenomenon that is responsible for TGA, as it is for migraines.…”

Section: Discussionmentioning

confidence: 88%

Co-occurrence of recurrent migrainous headaches and transient global amnesia following minor head trauma: a case report

Sonawalla,

Arshad,

Shafaq Saleem

2024

PJNS

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A 32-year-old male, with a history of recurrent throbbing headaches, presented with three episodes of minor trauma to the head followed by throbbing headaches and blurred vision. In two of these episodes, he also had clinical features suggesting the occurrence of transient global amnesia (TGA) at the same time. Although migraines as well as TGAs are reported to occur following minor head trauma, the simultaneous occurrence of both is rather unusual and would support the fact that spreading depression is the main pathophysiological mechanism underlying TGAs as it is for migraines. We report an unusual case of migraine and TGA occurring simultaneously in a footballer after minor head trauma.

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“…Very few cases have been explained using the proposed pathophysiology as the cause of TGA, and the majority of those cases were exertion-induced TGA from a case of a 52-year-old man with headaches triggered by sexual intercourse to a 21-year-old collegiate pitcher with type 1 diabetes [9,10]. Coincident health conditions have been recognized as risk factors for developing TGA in all those cases.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Exercise-Induced Transient Global Amnesia as an Exclusive Presenting Symptom of Hippocampus Infarct

Tonna,

Azma

2024

Cureus

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Transient global amnesia (TGA) is a rare condition characterized by a temporary loss of the ability to form new memories. Retrograde episodic memory loss may also occur but to a lesser extent. Although TGA is generally benign, its sudden onset and similarity to more dangerous conditions like transient ischemic attack (TIA) or cerebral vascular accident (CVA) can be concerning. We present the case of a 70-year-old female who experienced confusion and general memory loss after a vigorous workout on her stationary exercise bike. After displaying considerable amnestic symptoms, she was admitted to the hospital for further medical attention and underwent a magnetic resonance imaging (MRI) that concluded a TGA diagnosis. This case report aims to investigate the prognosis associated with risk factors and refine the diagnostic criteria of TGA. We explore whether TGA caused by exercise, leading to unilateral or bilateral hippocampal lesions, is linked to cognitive decline. It is not yet clear if the development of TGA with unilateral infarct or bilateral hippocampal lesions results in different clinical presentations or varying prognoses. Further research is needed to determine the long-term risks of cognitive decline associated with resulting infarcts and clinical presentations.

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Transient Global Amnesia in a Collegiate Baseball Player with Type I Diabetes Mellitus: A Case Report

Cited by 9 publications

References 10 publications

Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats

Co-occurrence of recurrent migrainous headaches and transient global amnesia following minor head trauma: a case report

A Rare Case of Exercise-Induced Transient Global Amnesia as an Exclusive Presenting Symptom of Hippocampus Infarct

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