Transient gall bladder dilatation associated with hypokalaemia in a patient with Bartter syndrome

Goren, Avner; Drachman, R.; Hadas-Halperin, Irit; Drukker, Alfred

doi:10.1007/bf01995853

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…We are hesitant to extrapolate the behaviour of hepatoma cells given an EPA-predominant fatty acid environment in culture to hepatic function in intact subjects for whom maximal plasma levels of EPA, as well as its proportion of the plasma NEFA pool, are considerably lower. Nevertheless, we are concerned that antiproliferative effects of n -3 PUFAs have been observed in vivo [58,59], and that fish-oil treatment is finding its way into paediatric use [75]. Until the effects of fishoil n -3 PUFAs on hepatocyte proliferation are better understood, perhaps they should be administered cautiously in clinical situations where continued hepatic growth or regeneration is desirable.…”

Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic acid inhibits cell growth and triacylglycerol secretion in McA-RH7777 rat hepatoma cultures

Fox

Hay

1992

Biochemical Journal

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The plasma triacylglycerol-decreasing effect of fish-oil fatty acids was studied in vitro by using the rapidly growing cultured rat hepatoma cell line McA-RH7777. Cells were exposed to albumin-complexed eicosapentaenoic acid (C20:5n-3; EPA), to oleic acid (C18:1n-9; OA), or to albumin alone. Cell growth was similar in albumin- and OA-supplemented cultures, but EPA treatment inhibited growth. As estimated by [14C]glycerol incorporation, OA stimulated both net triacylglycerol synthesis and secretion over control levels in a dose-dependent manner. EPA stimulated triacylglycerol synthesis in similar fashion to OA, but paradoxically decreased net triacylglycerol secretion and led to exaggerated intracellular accumulation of radiolabelled triacylglycerol. The EPA and OA effects were additive at low concentrations of total fatty acid, but at higher fatty acid concentrations OA appeared to negate some effects of EPA. Chemical analysis of albumin- and OA-treated cultures revealed OA-dominant profiles for both cellular and medium triacylglycerol-associated fatty acids. In contrast, EPA was the principal fatty acid in cellular triacylglycerol of EPA-supplemented cultures, whereas medium triacylglycerol from these cultures contained very little EPA. We conclude that McA-RH7777 hepatoma cells readily synthesize EPA-containing triacylglycerol molecules, but they have variable capacity for secreting them. We consider potential mechanisms to account for the effects of EPA in this system.

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Section: Discussionmentioning

confidence: 99%

Eicosapentaenoic acid inhibits cell growth and triacylglycerol secretion in McA-RH7777 rat hepatoma cultures

Fox

Hay

1992

Biochemical Journal

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“…Abdominal pain, vomiting, and RUQ mass in abdominal examination are the typical presentations of gallbladder hydrops. Kawasaki syndrome ( 5 ), mesenteric adenitis with pressure over cystic duct ( 5 ), streptococcal and staphylococcal infections with the associated toxin production ( 6 ), viral hepatitis, Henoch-Schoenlein purpura ( 7 ) and hypokalemia ( 8 ) had reported association with hydrops of gallbladder. Other etiologies include tumors, polyps or malignancy of the gallbladder, spontaneously resolved acute cholecystitis, congenital narrowing of the cystic duct, parasites such as ascaris (occasionally), prolonged parenteral nutrition, typhoid, leptospirosis, and appropriate response to ceftriaxone therapy ( 1 ).…”

Section: Discussionmentioning

confidence: 99%

Gallbladder Hydrops Due to Viral Hepatitis A Infection: A Case Report

Aldaghi

Haghighat

Dehghani

2015

Jundishapur J Microbiol

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Introduction:Acute Hepatitis A Virus (HAV) infection is common in the developing countries among children, but hydrops of gallbladder due to hepatitis A infection is an uncommon presentation.Case Presentation:A five-year-old boy was admitted in Namazi Hospital, Shiraz, Iran due to jaundice and severe abdominal pain for 10 days. Physical examination revealed a mass in the right upper quadrant with severe tenderness. Liver function tests were abnormal while other laboratory data such as blood urea nitrogen, serum creatinine, sodium, and potassium were within the normal range. Blood and urine cultures were negative. Abdominal ultrasonography showed that the gallbladder was very much distended and its fundus was near the iliac crest. Hydrops of the gallbladder was diagnosed. HAV IgM titer was high. After five days, without any specific treatment, his symptoms improved and he was discharged with good condition.Conclusions:Acute acalculous gallbladder disease is a rare complication of HAV infection which should be suspected in any child with right upper quadrant abdominal pain, tenderness, and mass which can lead to surgical emergency in rare conditions.

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B

Lachman¹

2007

Taybi and Lachman's Radiology of Syndromes, Metabolic Disorders and Skeletal Dysplasias

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Transient gall bladder dilatation associated with hypokalaemia in a patient with Bartter syndrome

Cited by 4 publications

References 7 publications

Eicosapentaenoic acid inhibits cell growth and triacylglycerol secretion in McA-RH7777 rat hepatoma cultures

Eicosapentaenoic acid inhibits cell growth and triacylglycerol secretion in McA-RH7777 rat hepatoma cultures

Gallbladder Hydrops Due to Viral Hepatitis A Infection: A Case Report

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