Transient elastography in patients with cystic fibrosis

Menten, Renaud; Leonard, Anissa; Clapuyt, Philippe; Vincke, P.; Nicolae, Alexandra Cristina; Lebecque, Patrick

doi:10.1007/s00247-009-1531-z

Cited by 83 publications

(80 citation statements)

References 34 publications

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“…Pathognomonic hepatic manifestations of cystic fibrosis (CF) is biliary cirrhosis which leads to CF-associated liver disease (CFLD) in around one-quarter of patients [21]. Conventional ultrasound examination with B-mode seems to be insufficient in assessing liver condition in patients with CF [22].…”

Section: Cf-associated Liver Diseasementioning

confidence: 99%

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Ultrasound Elastography - Review of Techniques and Its Clinical Applications in Pediatrics - Part 1

Pawluś¹,

Sokołowska-Dąbek²,

Szymańska

et al. 2015

Adv Clin Exp Med

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Sonoelastography is a novel technique that uses ultrasound waves to assess the elasticity of tissues noninvasively. It provides an ultrasound-based method to detect and display the relative stiffness of tissue. The main principle of sonoelastography is the measurement of tissue distortion in response to external compression. Changes in elasticity and tissue deformation elicited by compression are measured, processed and then shown in real time presentation with color-coded elastograms. One of the most important applications of sonoelastography is the evaluation of liver diseases, mainly liver fibrosis assessment and staging. Although in terms of definite diagnosis the liver biopsy still remains the golden standard, elastography seems to be a very inexpensive, repeatable and noninvasive method to evaluate most of liver conditions. The technique is also applicable in detection and differential diagnosis of focal lesions. It provides better imaging information and therefore more accurate evaluation of the lesions nature, e.g. in liver, lymphatic nodes or thyroid gland. Most of the applications mentioned above are well known and have been described in details in adults. Similarly, most of sonoelastographic studies are based on groups of adults. The purpose of this review article is to bring this technology closer to pediatric clinicians and to summarize some of its current clinical applications that are being pursued. In this part we focus on utility of elastography in liver assessment in pediatric patients (Adv Clin Exp Med 2015, 24, 3, 537-543).

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Section: Cf-associated Liver Diseasementioning

confidence: 99%

“…Research conducted by Behrens et al and Menten et al compares respectively ARFI and TE value to B-mode. In spite of its good results, its value is slightly decreased due to this limitation [21,23]. Friedrich-Rust et al used ARFI, TE and biochemical markers of fibrosis on 106 adult patients with fibrosis.…”

Section: Cf-associated Liver Diseasementioning

confidence: 99%

Ultrasound Elastography - Review of Techniques and Its Clinical Applications in Pediatrics - Part 1

Pawluś¹,

Sokołowska-Dąbek²,

Szymańska

et al. 2015

Adv Clin Exp Med

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“…Especially in adult patients with chronic hepatic diseases, a strong association of liver stiffness measured by FS and the histologically determined degree of liver fibrosis was shown [9][10][11]. Recently, this method was shown to provide valid results in pediatric patients with liver diseases, such as viral hepatitis, Wilson disease, alpha-1-antitrypsin deficiency, and cystic fibrosis [12,13]. We analyzed the detection of liver fibrosis using FS compared with conventional ultrasound in pediatric patients with cystic renal diseases.…”

Section: Introductionmentioning

confidence: 97%

Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection

et al. 2011

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Cystic renal diseases are characterized by intrarenal cysts of different size and number. Further important diagnostic criteria include, e.g., liver fibrosis. The latter represents a significant cause of morbidity and mortality in autosomal-recessive polycystic kidney disease (ARPKD), whereas patients with autosomal-dominant polycystic kidney disease (ADPKD) can develop hepatic cysts without fibrosis. We report the use of transient elastography [FibroScan®, (FS)] for early and noninvasive detection of increased liver stiffness as marker of liver fibrosis. Compared with matched healthy controls, ADPKD patients (n = 7) showed no significant difference in liver stiffness (5.3 kPa vs. 4.5 kPa; ns). ARPKD patients (n = 7) had significantly increased median liver stiffness compared with controls (12.0 kPa vs. 4.5 kPa, p = 0.002) and ADPKD patients (12.0 kPa vs. 5.3 kPa, p = 0.002). Conventional ultrasound revealed evidence of liver fibrosis in only four of seven ARPKD patients (57%) compared with 100% detection by FS. Additional laboratory examinations showed no pathologic liver parameters. In conclusion, our data found FS to be a valuable, sensitive, and noninvasive new tool for early evaluation of liver fibrosis in cystic kidney diseases. This could facilitate diagnosis, monitoring, and management of liver involvement in ARPKD or any other cystic kidney disease.

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“…Similarly, another study found that elasticity values of controls, pancreatic sufficient CF patients and pancreatic insufficient CF patients with an ultrasound showing either normal or homogenously hyperechoic livers, were comparable and significantly lower than in CF patients with heterogenous, nodular livers or with evidence of portal hypertension on ultrasound (P <0.002). Interestingly, it was found that male adults and male children with CF had significantly higher liver stiffness than females in the same group (P=0.0013) (31).…”

Section: Cystic Fibrosismentioning

confidence: 99%

Ultrasound elastography in the noninvasive diagnosis of liver disease in children: A review

Sleman

Liszewski

2016

Pedaiatr Today

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Transient elastography in patients with cystic fibrosis

Abstract: Considering the limitations of US and the low risk-benefit rate of liver biopsy in most CF patients, this preliminary study suggests that TE is an attractive non-invasive way to assess and follow-up liver disease in these patients.

Cited by 83 publications

References 34 publications

Ultrasound Elastography - Review of Techniques and Its Clinical Applications in Pediatrics - Part 1

Ultrasound Elastography - Review of Techniques and Its Clinical Applications in Pediatrics - Part 1

Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection

Ultrasound elastography in the noninvasive diagnosis of liver disease in children: A review

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