Ultrasound elastography in the noninvasive diagnosis of liver disease in children: A review

Sleman, Ingy H.; Liszewski, Mark C.

doi:10.5457/p2005-114.134

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Also, the recent review of Sleman et al . underlined the importance of ultrasound elastography as a method for assessing the evolution and prognosis of chronic liver conditions in children 26 . Bailey et al .…”

Section: Discussionmentioning

confidence: 99%

The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography

Mărginean

Meliţ

Ghiga

et al. 2019

Sci Rep

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The aim of this study was to assess the liver stiffness values in children with obesity versus healthy children on 2D-SWE and TE taking into account different laboratory parameters. We performed a case-control study on 287 children aged between 3 to 18 years, admitted in a Romanian Pediatric Tertiary Hospital, which we divided according to the body mass index (BMI) into two groups: the study group-77 children with obesity, and control group-210 children with normal weight. All children underwent anamnesis, clinical exam, laboratory parameters, ultrasound exam, and elastography. Children with obesity presented higher values of platelets, AST, ALT, and AAR as compared to control group (p = 0.0005/p = 0.0065/p < 0.0001/p < 0.0001). We found no significant differences for APRI between the two groups (p = 0.9827), although the values were higher in children with obesity. Significantly higher values of liver stiffness in children with obesity on both 2D-SWE and TE (p = 0.0314/p < 0.0001) were obtained. Similarly, the velocity values measured by 2D-SWE were also significantly higher in the study group (p < 0.0001). Our findings revealed significantly higher levels of platelets, transaminases, AAR, and liver stiffness values on both TE and 2D-SWE in children with obesity. 2D-SWE and TE might represent useful non-invasive methods for predicting liver impairment associated to pediatric obesity.

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Section: Discussionmentioning

confidence: 99%

The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography

Mărginean

Meliţ

Ghiga

et al. 2019

Sci Rep

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“…[ 35 ] Elastography is an essential non-invasive method in assessing the evolution and prognosis of chronic liver conditions in children. [ 36 ] Nevertheless, concerns were raised regarding certain limitation of 2D-SWE method in terms of discrimination between low-grade fibrosis and normal liver tissue. [ 37 ] Moreover, it was also hypothesized that liver inflammation, necrosis, fatty infiltration or edema might represent possible confounders for liver stiffness measurements.…”

Section: Discussionmentioning

confidence: 99%

The gap between overweight and obesity status in children - (STROBE-compliant article)

Mărginean¹,

Meliţ²,

Huţanu

et al. 2021

Medicine

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Overweight might represent only the early stage of obesity or it might act as a trigger of self-awareness turning into an ideal chance for preventing further obesity development. The aim of this study was to assess the differences between overweight and obese children in terms of anthropometric, low-grade systemic inflammation, liver impairment and atherosclerotic risk. We performed a study on 132 children aged between 5 and 18 years, divided according to the BMI into 2 groups: group 1 to 76 obese children, and group 2 to 56 overweight children, assessing anthropometric, laboratory and elastography parameters. We obtained significantly higher values of anthropometric parameters in obese children versus overweight ones. We found higher levels of leukocytes, lymphocytes, AST, ALT, and E median ( P = .0345, P = .0103, P < .0001, P = .0008 and P < .0001) in the obese group as compared to the overweight one. BMI was positively correlated with neutrophils, NLR, ESR, glycemia, anthropometric parameters, and E median ( P = .0007/<.0001/.0018/.0044/<.0001/<.0001/<.0001/<.0001/<.0001/.0204); and negatively with lymphocytes and HDL-cholesterol ( r = −0.2747/−0.2181, P = .0116/.0120). Our study underlined significant differences between overweight and obese children in terms of inflammatory status and liver impairment suggesting that the risk is directly related to the increase in BMI.

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“…The role of ultrasonography in the diagnosis and monitoring of chronic liver diseases is well known. Recent developments in ultrasound elastography are very well addressed here (6) and though further research is needed, they point to elastography as a potentially useful tool in assessing the extent and progression of chronic liver diseases in children. This will be especially welcome in patients who suffer from cystic fibrosis, where there are many developments in the treatment of their pulmonary abnormalities, which leads in turn to a much increased life ex-pectancy.…”

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confidence: 99%

Updates on some current issues in paediatric imaging

Donoghue

2016

Pedaiatr Today

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Ultrasound elastography in the noninvasive diagnosis of liver disease in children: A review

Cited by 4 publications

References 30 publications

The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography

The assessment of liver fibrosis in children with obesity on two methods: transient and two dimensional shear wave elastography

The gap between overweight and obesity status in children - (STROBE-compliant article)

Updates on some current issues in paediatric imaging

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