Transient directing ligands for selective metal-catalysed C–H activation

Diastereoselective palladium-catalyzed functionalization of prochiral C(sp3)–H bonds of aliphatic and alicyclic compounds

“…The transition metal-catalyzed C–H activation and functionalization in organic compounds is emerging as a remarkable transformation for installing functional groups. 1–9 The reports by Murahashi, Fahey, and Murai are notable initial contributions concerning the C–H functionalization of small organic molecules. 10 Various transition metal catalysts including Pd, Rh, Ni, Cu, Ru, Co, and Ir, have been used for accomplishing C–H functionalization reactions.…”

“…10 Various transition metal catalysts including Pd, Rh, Ni, Cu, Ru, Co, and Ir, have been used for accomplishing C–H functionalization reactions. 1–10 Especially, Pd( ii )-based catalysts are frequently used for realizing the functionalization of C–H bonds. 1–9 In general, the Pd( ii )-catalyzed, C–H functionalization of organic compounds has been accomplished with and without the assistance of directing groups (DGs).…”

“…1–10 Especially, Pd( ii )-based catalysts are frequently used for realizing the functionalization of C–H bonds. 1–9 In general, the Pd( ii )-catalyzed, C–H functionalization of organic compounds has been accomplished with and without the assistance of directing groups (DGs). 1–9…”

“…1–9 In general, the Pd( ii )-catalyzed, C–H functionalization of organic compounds has been accomplished with and without the assistance of directing groups (DGs). 1–9…”

“…Thus, the Pd( ii )-catalyzed, site-selective C–H activation of inactive C(sp 3 )–H bonds of aliphatic compounds has transpired solely with the help of various types of DGs and this strategy has been well studied in recent years. 1–9 In parallel, Baudoin and other research groups have established the intramolecular C(sp 3 )–H arylation under palladium(0) catalysis. This strategy involves the use of oxidative addition of a carbon-leaving group bond to palladium(0) to induce intramolecular C(sp 3 )–H activation in a suitable substrate, generating a cyclic compound via C(sp 2 )–C(sp 3 ) coupling.…”