Diastereoselective palladium-catalyzed functionalization of prochiral C(sp³)–H bonds of aliphatic and alicyclic compounds

Abstract

We highlight the reported developments of the palladium-catalyzed C–H activation and functionalization of the inactive/unreactive prochiral C(sp3)–H bonds of aliphatic and alicyclic compounds. There exist numerous classical methods for generating...

Pd(ii)-catalyzed selective β-C–H functionalization of azobenzene carboxamides

“…The transition metal-catalyzed C–H activation and functionalization, especially, the Pd( ii )-catalyzed C–H functionalization of organic substrates has transpired as one of the cornerstone strategies. 1,2 The site-selective C–H activation and functionalization of organic substrates have been accomplished by using appropriate directing groups (DGs). 1,2…”

“…1,2 The site-selective C–H activation and functionalization of organic substrates have been accomplished by using appropriate directing groups (DGs). 1,2…”

“…, 8-aminoquinoline (8-AQ) and picolinamide (PA)) has emerged as a benchmark strategy. 2,6 Taking an impetus from this strategy, we herein report the Pd( ii )-catalyzed 8-aminoquinoline DG-assisted, selective β-C–H arylation and alkylation of azobenzene motif 1c and synthesis of modified azobenzene carboxamides (Scheme 1).…”

The recent advances in cobalt-catalyzed C(sp3)–H functionalization reactions

“…Over the last two decades, efficient methods of C–H functionalization using precious metal catalysts such as palladium, rhodium or iridium have been developed. 3 However, their application is limited due to their relatively high cost, low natural abundance and high toxicity. Hence, there is an apparent need to explore and develop alternative catalysts that provide acceptable yields under feasible reaction conditions.…”

Nickel-Catalyzed Decarbonylative Reductive Alkylation of Aroyl Fluorides with Alkyl Bromides

“…In most approaches, combinations of aryl halides and alkyl metal reagents have been utilized, but the alkyl metal reagents generally require prior preparation from the corresponding alkyl halides. Given such a background, transition-metal-catalyzed direct C–H functionalization and cross-electrophile coupling have been developed independently to obviate the need for organometallic reagents and to simplify the synthetic procedure. The latter, also called reductive cross-coupling, could be conducted under neutral conditions, thus enabling the direct and efficient formation of C­( sp 2 )–C­( sp 3 ) bonds with a wide range of substrates applicable to the process.…”