Transglycosylated stevia and hesperidin as pharmaceutical excipients: Dramatic improvement in drug dissolution and bioavailability

α-Glucosyl hesperidin induced an improvement in the bioavailability of pranlukast hemihydrate using high-pressure homogenization

“…With respect to the statistical analysis, the one-way analysis of variance followed by Tukey-Kramer test was used in the case of multiple comparisons. We have already shown that there was no cytotoxicity to Caco-2 cells at levels of 10% Hsp-G solution (Uchiyama et al, 2010b). This amount was greater for PLH from HPH-processed particles than for untreated PLH at 1 h ( Fig.…”

Dry powder formulation with α-glycosyltransferase-treated stevia for the effective absorption of hydrophobic bioactive compounds in crude drugs

“…The tube was then incubated at 37°C with the shaking speed of the incubator fixed at 60 strokes per minute. After definite intervals (2,5,10,20,30, 60, 120, 180 min), samples of 1 ml were withdrawn and filtered through a 0.2-μm PTFE filter (Tokyo Roshi Kaisha, Japan). The concentrations of artepillin C and drupanin were determined by high-performance liquid chromatography as mentioned above.…”

“…The sweetness of Stevia-G may have the potential to mask the bitter taste of many compounds. We previously reported that the solid dispersion of a hydrophobic compound showed dramatically improved solubility and bioavailability when prepared with Stevia-G [20].…”

“…Various pharmaceutical techniques have been used to enhance the bioavailability of hydrophobic compounds, including the addition of surfactants [18] and the formation of solid dispersions [19,20]. Recently, we have focused on the feasibility of α-glycosyltransferase-treated stevia (Stevia-G) as a pharmaceutical excipient ingredient that would improve the dissolution and bioavailability of poorly water-soluble compounds.…”

Novel self-nanomicellizing solid dispersion based on rebaudioside A: a potential nanoplatform for oral delivery of curcumin

“…5 However, the therapeutic applications of Cur are severely limited by several of its characteristics, most notably its poor chemical/storage stability, low bioavailability due to poor membrane permeation, limited water solubility, rapid metabolism, and pronounced systemic elimination. 6 Literature shows few research reports on the utilization of stevioside and steviol as nanocarriers, [7][8][9][10][11][12] and no report has described the use of RA as a novel drug delivery system. The aim of the present work was to develop an RA-based selfnanomicellizing solid dispersion containing Cur (RA-Cur) that would increase Cur solubility and stability and enhance its antioxidant activity and oral bioavailability for the treatment of ulcerative colitis (UC).…”