Dry powder formulation with α-glycosyltransferase-treated stevia for the effective absorption of hydrophobic bioactive compounds in crude drugs

In Vitro and In Vivo Characterization of Drug Nanoparticles Prepared Using PureNano™ Continuous Crystallizer to Improve the Bioavailability of Poorly Water Soluble Drugs

“…The rats were fasted for 24 h before the experiments. Commercial APIs, PMs of APIs and PVA (1/1, w/w), and nanocrystal suspensions prepared by BC and PCC crystallization were orally administered (20 mg kg −1 solid content of phenytoin, 5 mg kg −1 solid content of flurbiprofen) using an oral dosing syringe after dispersion in 0.5% (w/v) carboxymethyl cellulose (CMC) solution after anesthetization with diethyl ether (23). Blood samples (600 μL) were taken from the jugular vein at 0.25, 0.5, 1, 2, 4, 8, 12, and 24 h after administration.…”