The poor water solubility
of rebamipide was enhanced by the mixed
micelles of transglycosylated stevia (Stevia-G) and trimethylammonium
chloride with varying carbon chain length (C
n
TAC, n = 14, 16, and 18). Fluorometry, isothermal
titration calorimetry (ITC) and dynamic light scattering techniques
examined the aggregation properties of Stevia-G and C
n
TAC. Synergism was found between Stevia-G and C
n
TAC using the approaches of Clint and Rubingh.
The negative interaction parameter (average β
m = −4.17, −5.47, and −7.07) and
excess free energy (average ΔG°
ex = −2.47, −3.06, and −3.88 kJ mol–1) increased with increasing chain length of C
n
TAC. The negative B
1 values by
the Maeda approach suggested that chain–chain interactions
contribute to the formation of a mixed micelle. The solubilization
of rebamipide in the mixed micelle was evaluated in the term of the
molar solubilization ratio (MSR) and partition coefficient (K
m). The K
m from
the Stevia-G/C16TAC system was highest at a low mole fraction
of C
n
TAC (0.2–0.6). In conclusion,
the solubilization of rebamipide was more favorable between Stevia-G
and C16TAC, although the stability of the mixed micelle
was enhanced by an increase in hydrophobicity of the longer chain
lengths used in C
n
TAC.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.