Transgenic plants as green factories for vaccine production

Abstract

Edible vaccine technology represents an alternative to fermentation based vaccine production system. Transgenic plants are used for the production of plant derived specific vaccines with native immunogenic properties stimulating both humoral and mucosal immune responses. Keeping in view the practical need of new technology for production and delivery of inexpensive vaccines, especially in developing world, plant derived edible vaccines is the best option in hand to combat infectious diseases. Plant derived vaccine is easy to administer, cost effective, readily acceptable, have increased safety, stability, versatility and efficacy. Several plant derived vaccines are under research, some are under clinical trials for commercial use. Like most biotechnology products, the IP situation for edible vaccines is complex as IP rights influence every stage of vaccine development.

Implementation Strategies for SME 4.0: Insights on Thailand

“…Further R&D can also lead to the production of edible vaccines (rabies vaccine, etc. ), medical-grade Marijuana (Kumar et al 2013;Sharma et al 1999;Yao et al 2015), Vitro meat (Bhat et al 2015;Datar and Betti 2010). Figure 12.13 illustrates the processes of strategic development and planning.…”

Ultraviolet-B induced responses of Psoralea corylifolia L. with special emphasis on: growth, anatomy, physiology, yield, essential oil content and composition

“…Its bioactive constituent psoralen along with UV-A radiation used in PUVA therapy for the cure of several skin diseases (Khushboo et al 2010). Taking into account the medicinal importance of P. corylifolia, there are only few reports available on abiotic stress response of P. corylifolia including, gamma radiation (Bhat et al 2015;Jan et al 2015) cadmium (Satdive et al 2014) SO 2 (Ali et al 2008) and salt stress (Katare et al 2012), however there are no reports yet available on the effect of UV-B radiation on P. corylifolia. Considering the literature lacunae, the present study was conducted to unravel the response of P. corylifolia against elevated UV-B radiation with the following objectives: (1) to evaluate the effect of eUV-B on growth, reproductive and anatomical features (ii) to estimate the effect of eUV-B on physiological parameters along with UV-B absorbing compounds under eUV-B (iii) to study the effect of eUV-B on medicinally important plant part i.e seeds and its essential content and composition.…”

Rapid production of therapeutic proteins using plant system

“…Plant molecular farming approach is most extensively used and it allows for the production of proteins in large quantities within a short time frame, this is particularly an attractive feature in case of pathogens that may be used for bioweapons and for epidemics 43 . Hence, plant-based vaccines that are transiently produced are with the native immunogenic properties stimulating both humoral and mucosal immune response 44 .Many industries like Medicago, Fraunhofer Center for Molecular Biotechnology/iBio, Fraunhofer IME, Icon Genetics, VAXX and Mapp Biopharmaceutical/LeafBio were the pioneer in plant based therapeutics productions. Medicago and Fraunhofer Center for Molecular Biotechnology/iBiohas developed virus like particles for vaccination against H1N1 and H5N1 within three weeks of receiving sequence information [45][46][47] .MappBiophamaceutical Inc., a USA based company has produced a drug in tobacco leaves called ZMapp, which has been used to combat Ebola virus outbreak in Africa.…”