Transfusion Transmissible Infections in Blood Donors in the Province of Bié, Angola, during a 15-Year Follow-Up, Imply the Need for Pathogen Reduction Technologies

Peliganga, Luis Baião; Mello, Vinicius M.; Sousa, Paulo Sérgio Fonseca de; Horta, Marco Aurélio Pereira; Soares, Álvaro Domingos; Nunes, João Pedro; Nobrega, Miguel; Lewis-Ximenez, Lia Laura

doi:10.3390/pathogens10121633

Cited by 19 publications

(16 citation statements)

References 42 publications

(79 reference statements)

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“… 17 , 18 In the current study the TTI prevalence was 5.4%, with HBV (2.8%) being the most prevalent, followed by Syphilis (1.5%), HIV (0.8%) and HCV (0.3%). Our finding was comparable with the output of studies conducted by Shiferaw et al, 11 Biadgo et al 19 and Arif et al 6 but relatively lower than the prevalence reported by Peliganga et al 10 and higher than that of Prakash et al 17 and Hroob et al 8 The observed difference in the prevalence of TTI markers may be due to differences in lifestyle and economic status of the study participants.…”

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

“…9 A study conducted in Angola also reported even a higher TTI prevalence in which HBV (8.4%) infection covered a larger proportion, followed by syphilis (4.4%), HCV (3%) and HIV (2.1%). 9,10 In Eritrea, the prevalence of HIV, HBV, HCV and Syphilis was 0.8%, 5%, 0.7% and 7.2%, respectively, and in Ethiopia, the overall prevalence of TTI was 6% (HBV = 3.9%, HCV = 0.6%, HIV = 0.5% and syphilis = 1.2%) in 2019. 11,12 Considering this high prevalence, the World Health Organization (WHO) recommended that, the blood and blood products collected for transfusion should be screened for HIV, HBV, HCV, and syphilis as a minimum requirement.…”

Section: Introductionmentioning

confidence: 99%

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Association of ABO and Rhesus Blood Types with Transfusion-Transmitted Infections (TTIs) Among Apparently Healthy Blood Donors at Bahir Dar Blood Bank, Bahir Dar, North West, Ethiopia: A Retrospective Cross-Sectional Study

Legese¹,

Shiferaw²,

Tamir³

et al. 2022

JBM

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Background Besides their clinical significance in blood transfusion medicine, ABO and Rh blood group antigens were found to be associated with many non-infectious and infectious diseases. This investigation aimed to assess the association of ABO and Rh blood group antigens with transfusion transmissible infections (TTIs). Methods and Materials A cross-sectional retrospective investigation was conducted on 27,027 blood donors at Bahir Dar blood bank, from March 24/2019 to October 21/2021. The blood sample was collected from each blood donor and tested for TTI markers (HBV, HCV, HIV, and syphilis), with ELISA, and ABO and Rh blood grouping was performed. Descriptive analysis was done for sociodemographic data, and a chi-square test was used to show the association between the ABO and Rh blood groups with TTI markers, and a P-value <0.05 was considered statistically significant. Results From 27,027 study participants, 18,911 (70%) were males, with a mean age of 25.2 years, and 49.4% of the blood donors were students. The overall TTI prevalence was 5.43%, of which 2.8% was HBV, 1.5% was syphilis, 0.8% was HIV, and 0.3% was HCV. Blood group O (41.4%) was the most common blood group followed by, A (29.6%), B (23.6%), and AB (5.4%). Ninety-one point seven percent of the blood donors were Rh (D) positive. All TTI markers (HBV: p = 0.62, HIV: p = 0.77, HCV: p = 0.52, and syphilis: p = 0. 0.94) showed no significant association with ABO blood group. Rh blood type also showed no association with all TTI markers. Conclusion The prevalence of TTI markers was not significantly associated with ABO and Rh blood groups.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of ABO and Rhesus Blood Types with Transfusion-Transmitted Infections (TTIs) Among Apparently Healthy Blood Donors at Bahir Dar Blood Bank, Bahir Dar, North West, Ethiopia: A Retrospective Cross-Sectional Study

Legese¹,

Shiferaw²,

Tamir³

et al. 2022

JBM

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“…Only two studies previously analyzed HCV-Ab prevalence in different age groups in Lao PDR, and both indicated that those aged 40 years or older had higher prevalence as compared with those aged younger than 40 years [19,31], which is consisstant with our study finding. Several studies in other countries have also indicated that the prevalence of HCV infection increases with age [44][45][46]. However, there were no positive cases among the participants younger than 30 years in our survey, suggesting that horizontal transmission in adults might be the main route of infection rather than vertical transmission.…”

Section: Plos Onecontrasting

confidence: 66%

Prevalence of hepatitis B and C virus infections in Lao People’s Democratic Republic: The first national population-based cross-sectional survey

Miyano

Pathammavong²,

Ichimura

et al. 2022

PLoS ONE

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Population-based seroprevalence of chronic hepatitis B and C infections has not been examined in Lao People’s Democratic Republic (PDR). Therefore, this study aimed to estimate the seroprevalence of these infections in the general population of Lao PDR and perform subgroup analysis. A nationwide seroprevalence survey was conducted in Lao PDR in June 2019 using the multistage cluster sampling method. Dried blood spot samples were collected onto WhatmanTM 903 filter paper by finger prick. A chemiluminescent microparticle immunoassay was used to measure the levels of hepatitis B surface antigen (HBsAg) and hepatitis C antibody (HCV-Ab). Samples in which the HBsAg level was above 0.05 IU/ml and HCV-Ab was above the signal/cutoff ratio of 1.0 were considered positive based on comparisons with the relative light unit value of a calibration sample. A total of 1,927 samples (male: 47.3%, mean age: 23.0 years) were included in the analysis. The prevalence was estimated to be 4.2% (95% confidence interval [CI]: 2.7–6.3) for HBsAg and 1.6% (95% CI: 0.5–5.3) for HCV-Ab. Multivariable analysis revealed that those aged 20–24 years (adjusted odds ratio (AOR): 2.3, 95% CI: 1.1–4.6), those aged 25–29 years (AOR: 2.7, 95% CI: 1.3–5.6), those from the Northern region (AOR: 2.8, 95% CI: 1.2–6.6), and those who were Khmu (AOR: 3.6, 95% CI: 2.0–6.8) or Hmong (AOR: 5.0, 95% CI: 3.3–7.5) were significantly more likely to be positive for HBsAg. Although there were no statistically significant differences in the HCV-Ab prevalence according to each variable, males (2.9%, 95% CI: 0.7–10.7), those aged ≥40 years (6.1%, 95% CI: 2.1–16.8), and those from the Southern region (3.3%, 95% CI: 0.6–15.3) tended to have a higher prevalence. This novel population-based survey found differences in the prevalence of chronic hepatitis B and hepatitis C virus infections in Lao PDR according to sex, age group, region, and ethnicity; however, the results of this study should be confirmed in future studies, and relevant responses tailored for each target also need to be determined to control the transmission of hepatitis B and C infections.

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“…In many countries, the majority of blood donors are men. 15 , 16 In Shenzhen of China, from 2013 to 2021, there were more male blood donors than females. It may because of the existence of menstrual period, which limits women to donate blood.…”

Section: Discussionmentioning

confidence: 99%

Demographic Factors Among HIV Confirmed Blood Donors from 2013 to 2021 in Shenzhen

Wang¹,

Sun²,

Qi³

et al. 2023

IJGM

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Background New HIV (Human immune deficiency virus) infections are continuously increasing in China and it remains a huge challenge to blood donation. As access to health services has affected by COVID-19 (Corona virus disease 2019) pandemic, a drop in new diagnoses (especially HIV) was observed worldwide. Methods During 2013–2021, 735,247 specimens from unpaid blood donors collected by Shenzhen Blood Center underwent ELISA (Enzyme -linked immunosorbent assay) and NAT (Nucleic acid test). Samples with reactivity results were sent to the Shenzhen Center for Disease Control and Prevention for WB (Western blot). All data were statistically analyzed by the Chi-Square test. Results From 2013 to 2021, the prevalence of HIV among male blood donors was higher than in females (P < 0.01). During the COVID-19 pandemic, the prevalence of HIV among repeat blood donors decreased significantly compared to 2019 (P < 0.05), and the characteristics of blood donors changed in 2020 compared to 2019 and 2021. Conclusion The high proportion of female blood donors would help prevent HIV from getting into the blood supply. The COVID-19 pandemic affected the demographics of blood donors as well as the prevalence of HIV among repeat blood donors. An increased number of repeat blood donors can help decrease the risk of HIV transfusion transmission during the epidemic.

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Transfusion Transmissible Infections in Blood Donors in the Province of Bié, Angola, during a 15-Year Follow-Up, Imply the Need for Pathogen Reduction Technologies

Cited by 19 publications

References 42 publications

Association of ABO and Rhesus Blood Types with Transfusion-Transmitted Infections (TTIs) Among Apparently Healthy Blood Donors at Bahir Dar Blood Bank, Bahir Dar, North West, Ethiopia: A Retrospective Cross-Sectional Study

Association of ABO and Rhesus Blood Types with Transfusion-Transmitted Infections (TTIs) Among Apparently Healthy Blood Donors at Bahir Dar Blood Bank, Bahir Dar, North West, Ethiopia: A Retrospective Cross-Sectional Study

Prevalence of hepatitis B and C virus infections in Lao People’s Democratic Republic: The first national population-based cross-sectional survey

Demographic Factors Among HIV Confirmed Blood Donors from 2013 to 2021 in Shenzhen

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