Transfusion-Related Acute Lung Injury After Immunoglobulin Infusion for Kawasaki Disease: A Case Report and Literature Review

Ibrahim, Judy; Amri, Abdulla Al; Ghatasheh, Ghassan

doi:10.1177/2333794x17746545

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…However, it is important to note the limitations in diagnosing TRALI, including the lack of specific diagnostic tests and the need to exclude other causes of acute lung injury. Further research is needed to develop more specific and sensitive diagnostic tools for TRALI [9].…”

Section: Discussionmentioning

confidence: 99%

Acute Lung Injury Associated with Blood Transfusion in a Hysterectomy Patient: A Case Report

Bielinskyi,

Halandzhii,

Dashchenko

et al. 2024

Galician med. j.

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This case report presents a case of transfusion-related acute lung injury (TRALI) in a 50-year-old female patient who underwent total hysterectomy due to multiple fibromyomas. The patient developed dyspnea, heart palpitations, and fatigue postoperatively, with SpO2 dropping to 61%. Despite initially suspecting pulmonary embolism, the normal D-dimer level and characteristic changes observed on X-ray facilitated the diagnosis of TRALI. The patient was successfully treated with oxygen supplementation, intravenous corticosteroids, and thromboembolism prophylaxis, resulting in complete recovery. This case underscores the importance of considering TRALI in the differential diagnosis when patients exhibit respiratory distress following transfusion.

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Section: Discussionmentioning

confidence: 99%

Acute Lung Injury Associated with Blood Transfusion in a Hysterectomy Patient: A Case Report

Bielinskyi,

Halandzhii,

Dashchenko

et al. 2024

Galician med. j.

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“…This is defined as the onset of new respiratory distress occurring within 6 h of a transfusion, and is associated with non-cardiogenic pulmonary oedema [ 17 ]. It has been previously described following IVIG treatment for Kawasaki disease [ 18 ].…”

Section: Medium Vessel Vasculitismentioning

confidence: 99%

Pulmonary manifestations of systemic vasculitis in childhood

Lawton

Machta

Semple

et al. 2020

Breathe

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The systemic vasculitides are a heterogenous group of rare conditions with an incompletely understood aetiology. Any of the systemic vasculitides may cause respiratory disease, but some conditions are more likely to affect the pulmonary system, often through pulmonary infarction and diffuse alveolar haemorrhage. These conditions are often difficult to diagnose due to their rarity and significant clinical overlap with common respiratory conditions. Prompt diagnosis and management can significantly reduce morbidity and mortality.

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“…Al-though it is somehow self-limiting, 25% of untreated patients with KD develop coronary artery abnormalities, which have accepted risks of inducing ischemic heart disease, coronary artery aneurysms, or sudden death (Anand and Anand, 1995;Brogan et al, 2002). Recent studies have suggested that apart from coronary artery abnormalities, patients with KD have a predominant pulmonary presentation, such as cough, pleural effusion, atelectasis, respiratory distress, and bronchial ar-tery stenosis (Ibrahim et al, 2017;Singh et al, 2018;Umezawa et al, 1989;Vaidya et al, 2017). Notably, pulmonary arterial hypertension (PAH), pulmonary artery dilation, pulmonary artery aneurysms, and right ventricle (RV) dysfunction have been observed in patients with KD (Briceno-Medina et al, 2016;Escalon et al, 2018;Nicholson et al, 2013;Ugi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities

Shi

Yin

et al. 2020

Sci. China Life Sci.

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Clinical cases have reported pulmonary arterial structural and functional abnormalities in patients with Kawasaki disease (KD); however, the underlying mechanisms are unclear. In this study, a KD rat model was established via the intraperitoneal injection of Lactobacillus casei cell wall extract (LCWE). The results showed that pulmonary arterial functional and structural abnormalities were observed in KD rats. Furthermore, proliferative endoplasmic reticulum stress (ER stress) was observed in the pulmonary arteries of KD rats. Notably, the level of lipocalin-2 (Lcn 2), a trigger factor of inflammation, was remarkably elevated in the plasma and lung tissues of KD rats; increased Lcn 2 levels following LCWE stimulation may result from polymorphonuclear neutrophils (PMNs). Correspondingly, in cultured pulmonary artery smooth muscle cells (PASMCs), Lcn 2 markedly augmented the cleavage and nuclear localization of activating transcription factor-6 (ATF6), upregulated the transcription of glucose regulated protein 78 (GRP78) and neurite outgrowth inhibitor (NOGO), and promoted PASMCs proliferation. However, proapoptotic C/EBP homologous protein (CHOP) and caspase 12 levels were not elevated. Treatment with 4-phenyl butyric acid (4-PBA, a specific inhibitor of ER stress) inhibited PASMCs proliferation induced by Lcn 2 and attenuated pulmonary arterial abnormalities and right ventricular hypertrophy and reduced right ventricular systolic pressure in KD rats. In conclusion, Lcn 2 remarkably facilitates proliferative ER stress in PASMCs, which probably accounts for KD-related pulmonary arterial abnormalities.

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Transfusion-Related Acute Lung Injury After Immunoglobulin Infusion for Kawasaki Disease: A Case Report and Literature Review

Cited by 5 publications

References 9 publications

Acute Lung Injury Associated with Blood Transfusion in a Hysterectomy Patient: A Case Report

Acute Lung Injury Associated with Blood Transfusion in a Hysterectomy Patient: A Case Report

Pulmonary manifestations of systemic vasculitis in childhood

Lipocalin-2-induced proliferative endoplasmic reticulum stress participates in Kawasaki disease-related pulmonary arterial abnormalities

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