Transfusion of ABO non-identical platelets increases the severity of trauma patients at ICU admission

Silva, Adriana Lucia de Oliveira; Bassolli, Lucas; Ferreira, Pedro; Utiyama, Edivaldo Massazo; Dezan, Marcia Regina; Costa-Neto, Abel; Conrado, Marina C. A. V.; Oliveira, Vítor Hugo de; Bonifácio, Sílvia L.; Fernandes, Frederico Leon Arrabal; Rocha, Vanderson; Mendrone‐Júnior, Alfredo; Dinardo, Carla Luana

doi:10.1016/j.htct.2020.06.011

Cited by 2 publications

(3 citation statements)

References 14 publications

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“…These diagnostic categories were selected based on the frequency with which patients received platelet transfusions and/or prior studies suggesting a possible impact of platelet transfusions on patient outcomes. The four diagnostic categories included were Hematology/ Oncology (Hem/Onc), 4 Trauma, 22,23 Cardiac Surgery, [24][25][26] and Intracerebral Hemorrhage (ICH). 5,27 For the dosedependent analysis, bidirectional mismatches were tabulated as both major and minor mismatches.…”

Section: Discussionmentioning

confidence: 99%

Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis

et al. 2023

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Background: Due to platelet availability limitations, platelet units ABO mismatched to recipients are often transfused. However, since platelets express ABO antigens and are collected in plasma which may contain ABO isohemagglutinins, it remains controversial as to whether ABO non-identical platelet transfusions could potentially pose harm and/or have reduced efficacy.Study Design and Methods: The large 4-year publicly available Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) database was used to investigate patient outcomes associated with ABO non-identical platelet

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Section: Discussionmentioning

confidence: 99%

Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis

et al. 2023

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“…To obviate the hemolytic complications of minor ABO incompatible platelets, some centres resolve to only transfusing major ABO incompatible platelets or ABO‐compatible platelets, the latter also having the lowest reported rate of transfusion reactions and reduced de novo red cell alloimmunization 7,9 . While this practice mildly increases outdating of platelets, it has been associated with improved patient outcomes in some settings and some studies have reported an associated patient survival benefit 9–13 . This is not always feasible for most blood banks given the short shelf life of platelet transfusions, the relative rarity of B and AB donors and the occasional need of HLA‐matched platelets.…”

Section: Discussionmentioning

confidence: 99%

“…7,9 While this practice mildly increases outdating of platelets, it has been associated with improved patient outcomes in some settings and some studies have reported an associated patient survival benefit. [9][10][11][12][13] This is not always feasible for most blood banks given the short shelf life of platelet transfusions, the relative rarity of B and AB donors and the occasional need of HLA-matched platelets.…”

Section: Isohemagglutinin Titrementioning

confidence: 99%

Severe acute haemolytic transfusion reaction secondary to a plasma incompatible group B platelet transfusion

Bienz

Gupta

Goldstein

et al. 2022

Transfusion Medicine

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Objectives: To report a rare case of acute hemolytic transfusion reaction (AHTR) following an ABO plasma incompatible group B platelet transfusion.Background: AHTR is an uncommon, but potentially fatal event. Most reported cases of platelet transfusions associated with AHTR involve group O donors.Case Report: A 34-year-old man, recipient of a group AB haploidentical haematopoietic stem cell transplantation (HSCT), had received re-induction chemotherapy for leukaemia relapse. A group B whole blood-derived buffy coat platelet pool was transfused. He developed rigours/fever, profound hemolytic anaemia, and hemodynamic instability. Serological investigations revealed AHTR from passive transfer of high titre anti-A (256 for IgM and 8192 for IgG).Discussion: This case highlights the potential risks associated with ABO-mismatched transfusions, and the complexity associated with transfusing HSCT recipients and red cell transfusion recipients with dual populations of circulating red cells. The literature on minor ABO plasma incompatible transfusions, challenges in establishing local policies to limit the risks of AHTR and risk mitigation strategies are discussed. Conclusion:Clinicians must maintain a high level of suspicion for AHTR after ABO plasma incompatible platelet transfusions. Patients must be aware of the risks of AHTR, and early recognition and diagnosis of this complication may be lifesaving.

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Transfusion of ABO non-identical platelets increases the severity of trauma patients at ICU admission

Cited by 2 publications

References 14 publications

Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis

Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis

Severe acute haemolytic transfusion reaction secondary to a plasma incompatible group B platelet transfusion

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