Transforming Growth Factor .BETA.1 +869T/C Gene Polymorphism and Essential Hypertension: A Meta-analysis Involving 2708 Participants in the Chinese Population

Abstract

Background The transforming growth factor β1 (TGFB1) +869T/C gene polymorphism has been suggested to be linked to susceptibility to essential hypertension (EH). Objective and Methods To investigate the relationship between TGFB1 +869T/C gene polymorphism and EH, 5 separate studies with 2,708 subjects in the Chinese population on the relation between TGFB1 +869T/ C gene polymorphism and EH were analyzed by meta-analysis. The random effect model was selected to calculate the pooled odds ratio (ORs) and its corresponding 95% confidence interval (95%). Results There was a significant association between TGFB1 +869T/C gene polymorphism and EH. The pooled OR for CC/TC+TT genotype was 2.50 (95% CI: 1.46-4.28, P heterogeneity <0.0001, p=0.0008). The pooled OR for the frequency of C allele was 1.43 (95% CI:1.18-1.73, P heterogeneity =0.02, p=0.0002). Conclusion The current meta-analysis suggested that C allele and CC genotype of TGFB1 +869T/C gene polymorphism might be related to the increased risk of EH in the Chinese population.

Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1

“…In humans, the 915C allele of a single nucleotide polymorphism in TGFB1, which leads to proline at residue 25 within the signal peptide sequence, has been associated in a European population with a reduced risk of hypertension (13). The 897C allele of a second polymorphism, which leads to proline at residue 10 within the signal peptide sequence, has been associated in an Asian population with an increased risk of hypertension (14,15), but whether or how the changes directly affect BP has not been determined.…”

The Role of Transforming Growth Factor &#946;1 in the Regulation of Blood Pressure

“…The 869C polymorphism, resulting in proline at residue 10 within the signal peptide sequence, is also associated with an increased risk of hypertension in an Asian population [36, 37]. Whether or not and how the polymorphisms affect blood pressure have not been elucidated.…”

Transforming growth factor beta1 and aldosterone

“…In humans, the 915C allele of a single nucleotide polymorphism in the TGFbeta1 gene ( TGFB1) , which leads to proline at residue 25 within the signal peptide sequence, has been associated in a population with a reduced risk of hypertension[13]. The 869C allele of a second polymorphism, which leads to proline at residue 10 within the signal peptide sequence, has been associated in a population with an increased risk of hypertension[14,15], but how the changes in the functional effects of TGFbeta1 affect blood pressure remains undetermined. Since they are polymorphisms in the coding region which presumably result in functional changes of the protein, it remains unclear whether they cause loss-of-function or gain-of-function.…”