Transforming “cold” tumors into “hot” ones via tumor-microenvironment-responsive siRNA micelleplexes for enhanced immunotherapy

Genetically Engineered Protein Corona‐based Cascade Nanozymes for Enhanced Tumor Therapy

“…We next sought to explore whether the nanoplatform generated cytotoxic 1 O 2 following the above reactions. Considering 1 O 2 is a strong oxidant that plays an important role during the process of PDT, we measured 1 by MSN-Au/Ce6-FTn-Ru with or without glucose/H 2 O 2 in normoxia and hypoxia using 1,3-Diphenylisobenzofuran (DPBF) as an indicator under NIR laser irradiation. Under normoxia, MSN-Au/Ce6-FTn-Ru produced a significant amount of 1 O 2 in different groups, regardless of the presence of glucose and/or H 2 O 2 (Figure 3h).…”

“…Tumor microenvironment (TME) plays an essential role in promoting tumor cell growth, angiogenesis and metastasis through complicated signal pathways. [ 1 ] The regulation of TME has been considered as an emerging strategy for cancer treatment. [ 2 ] The abnormal metabolism of cancer cells endows TME with unique features such as severe hypoxia and elevated H 2 O 2 and glucose levels.…”

Biomimetic dual-responsive bioengineered nanotheranostics for intracellular cascade-synthesizing chemo-drugs and efficient oncotherapy

“…3 In addition, as the physical environment, celluar metabolism, and biosynthetic intermediates of the tumor microenviroment (TME) are obviously different from those of normal cells or tissues, TMEresponsive nanotheranostics have received widespread attention. 4 Notably, a large number of studies have pointed out that TMEresponsive nanotheranostics can effectively aviod drug leakage during in vivo blood circulation and then unload the drugs via controlled release after reaching the tumor regions, thereby further reducing undesirable side effects of the drugs. 5,6 However, the direct introduction of toxic chemo-drugs still results in some non-negligible side effects.…”

Facile synthesis of phycocyanin/polydopamine hierarchical nanocomposites for synergizing PTT/PDT against cancer

“…Photodynamic therapy (PDT) is an emerging and promising noninvasive cancer treatment modality that employs exogenous light as the energy donor to specically activate photosensitizer drugs (PSs) pre-localized in tumor cells and then converts surrounding O 2 /H 2 O into virulent reactive oxygen species (ROS, including 1 O 2 /$O 2 − ) to damage cellular content through energy transportation and translation. [1][2][3][4][5][6] As a key player in this photodynamic process, PSs determined the reaction rate, intensity, and ROS yield, all of which are strongly correlated with the species, biocompatibility, and accumulation of PSs in diseased tissue. [7][8][9] In recent years, researchers found that some natural proteins containing porphyrin structures, superior to representative organic porphyrin molecules, are capable of serving as desired PSs to improve tumor accumulation while reducing harmful effects to the body.…”

“…) to damage cellular content through energy transportation and translation. [1][2][3][4][5][6] As a key player in this photodynamic process, PSs determined the reaction rate, intensity, and ROS yield, all of which are strongly correlated with the species, biocompatibility, and accumulation of PSs in diseased tissue. [7][8][9] In recent years, researchers found that some natural proteins containing porphyrin structures, superior to representative organic porphyrin molecules, are capable of serving as desired PSs to improve tumor accumulation while reducing harmful effects to the body.…”