Biomimetic dual-responsive bioengineered nanotheranostics for intracellular cascade-synthesizing chemo-drugs and efficient oncotherapy

Abstract

Intracellular chemo-drugs synthesis based on the inherent characteristics of tumor microenvironment (TME) have been extensively applied to oncotherapy. Nevertheless, how to combine other therapeutic strategies to convert non-toxic small molecules...

TME-triggered copper-coordinated engineered programmable nanogenerators for on-demand cascade-amplifying oxidative stress

“…In vitro drug release of ECH was evaluated by a dialysis method. 34 In brief, 3 mL of ECH solution (1 mg mL −1 ) was taken in a dialysis bag (molecular weight cut-off of 1000 Da) which was immersed into 47 mL 1 × PBS in different environments (pH 7.4, pH 6.5, and pH 5.0 with/without 10 mM GSH). Subsequently, the above-mentioned solution was shaken at 100 rpm at 37 °C for 48 h. Additionally, 3 mL of solution outside the dialysis bag was removed within predesigned time periods (0, 0.5, 1, 2, 4, 6, 9, 12, 24, and 48 h) and then 3 mL of corresponding fresh PBS was supplemented.…”

Anti-corrosion properties of bio-inspired surfaces: a systematic review of recent research developments

“…The prepared ZIF-8/POTS/EP composite coatings exhibited good water repellency and mechanical and chemical stability and remained superhydrophobic after 300 days of aging in air or 60 days of immersion in 3.5 wt% NaCl aqueous solution. addition, Zhang et al 141 successfully prepared purely hydrophobic PDMS surfaces and superhydrophobic candle soot (CS) deposited surfaces, as well as bilayer PDMS-CS coatings by scraping and CS incomplete combustion deposition. PDMS acted as a binder in the composite coatings, effectively connecting the outer layer of CS to the bottom aluminum substrate.…”