Transforming an inert nanopolymer into broad-spectrum bactericidal by superstructure tuning

Scilletta, Natalia A.; Pezzoni, Magdalena; Desimone, Martín Federico; Soler-Illia, Galo J.A.A.; Catalano, Paolo N.; Bellino, Martín G.

doi:10.1016/j.colsurfb.2019.02.056

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…As an example of the described methodologies, results of the antibacterial activity of mesostructured titania thin film coatings on Salmonella typhimurium are shown (Scilletta et al, 2019). For this purpose, hybrid titania-Pluronic mesostructured thin films were synthesized by the sol-gel method in combination with evaporation-induced self-assembly of the pluronic micelles, according to protocols described in the literature (Crepaldi et al, 2003;Soler-Illia et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

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Determination of Antibacterial Activity of Film Coatings against Four Clinically Relevant Bacterial Strains

et al. 2021

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Antibacterial coatings have currently gained great importance in biomedical technology investigations. Because of the spatial arrangement of the film coatings, evaluation of antibacterial activity presents a new challenge regarding traditional bacterial counting methods. In this protocol, four clinically relevant pathogens, Salmonella typhimurium, Escherichia coli, Pseudomonas aeruginosa,and Staphylococcus aureus were incubated on titania mesostructured thin film coatings for 24 h. Then, cell viability was studied considering three methods: counting of the number of colony forming units (CFU), live/dead staining, and quantification of extracellular DNA in suspension. Firstly, bacterial count was determined by the standard plate-count technique. Secondly, bacteria membrane integrity was evaluated by utilization of two fluorescent dyes, which allow distinction between live (membrane intact) and dead (membrane disrupted) bacteria. Lastly, extracellular DNA was quantified by spectrophotometry. In this manner, the three aforementioned techniques enabled the study of bacterial viability by qualitative and quantitative analyses.

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Section: Discussionmentioning

confidence: 99%

“…These modifications modulate the mesophase, which we proved is directly related to the bactericidal capacity. The mesostructured titania thin film coatings were synthesized by the sol-gel method in combination with evaporation-induced self-assembly of the pluronic micelles and deposited by spin-coating on glass substrates (Scilletta et al, 2019).…”

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confidence: 99%

Determination of Antibacterial Activity of Film Coatings against Four Clinically Relevant Bacterial Strains

et al. 2021

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“…[196] These special TiO 2 nanostructures have attracted much interest in the biomedical field due to their unique characteristic of compatibility with biological systems. [197,198] The synthesis, mechanical properties, biocompatibility, effect on osseointegration, cell differentiation, mineralization, and antimicrobial properties of titanium nanotubes have been recently reviewed by Su et al, Mydin, and Cheng et al, [199][200][201] so, it will not be covered in this review.…”

Section: Collagen In Bone Defects Of Different Types Of Bonementioning

confidence: 99%

Recent Advances in Synthetic and Natural Biomaterials‐Based Therapy for Bone Defects

Echazú

Perna

Olivetti

et al. 2022

Macromolecular Bioscience

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Synthetic and natural biomaterials are a promising alternative for the treatment of critical-sized bone defects. Several parameters such as their porosity, surface, and mechanical properties are extensively pointed out as key points to recapitulate the bone microenvironment. Many biomaterials with this pursuit are employed to provide a matrix, which can supply the specific environment and architecture for an adequate bone growth. Nevertheless, some queries remain unanswered. This review discusses the recent advances achieved by some synthetic and natural biomaterials to mimic the native structure of bone and the manufacturing technology applied to obtain biomaterial candidates. The focus of this review is placed in the recent advances in the development of biomaterial-based therapy for bone defects in different types of bone. In this context, this review gives an overview of the potentialities of synthetic and natural biomaterials: polyurethanes, polyesters, hyaluronic acid, collagen, titanium, and silica as successful candidates for the treatment of bone defects.

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“…The design and development of novel materials and devices for medicine is one of the exciting new areas of bioengineering and biotechnology, which is rapidly gaining the attention of the scientific community (Zhang et al, 2011;Hardy et al, 2013;Copes et al, 2019;Hu and de Vos, 2019;Tamay et al, 2019). Biofabrication is providing scientists and clinicians the ability to produce engineered devices with desired shapes, chemical composition, and biological functions (Echave et al, 2019;Scilletta et al, 2019;Debons et al, 2020;Frayssinet et al, 2020). In the last few decades, several biomaterials and nanomaterials have been proposed and develop to this end (Desimone et al, 2010;Scodeller et al, 2013;Alvarez et al, 2014;Mebert et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

Mendoza

Scilletta

Bellino

et al. 2020

Front. Bioeng. Biotechnol.

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In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least invasiveness and the greatest possible automation. Some of the factors that challenge conventional drug release include longterm treatments, narrow therapeutic windows, complex dosing schedules, combined therapies, individual dosing regimens, and labile active substance administration. In this sense, the emergence of micro-devices that combine mechanical and electrical components, so called micro-electro-mechanical systems (MEMS) can offer solutions to these drawbacks. These devices can be fabricated using biocompatible materials, with great uniformity and reproducibility, similar to integrated circuits. They can be aseptically manufactured and hermetically sealed, while having mobile components that enable physical or analytical functions together with electrical components. In this review we present recent advances in the generation of MEMS drug delivery devices, in which various micro and nanometric structures such as contacts, connections, channels, reservoirs, pumps, valves, needles, and/or membranes can be included in their design and manufacture. Implantable single and multiple reservoir-based and transdermalbased MEMS devices are discussed in terms of fundamental mechanisms, fabrication, performance, and drug release applications.

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Transforming an inert nanopolymer into broad-spectrum bactericidal by superstructure tuning

Cited by 6 publications

References 32 publications

Determination of Antibacterial Activity of Film Coatings against Four Clinically Relevant Bacterial Strains

Determination of Antibacterial Activity of Film Coatings against Four Clinically Relevant Bacterial Strains

Recent Advances in Synthetic and Natural Biomaterials‐Based Therapy for Bone Defects

Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications

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