Recent Advances in Synthetic and Natural Biomaterials‐Based Therapy for Bone Defects

Echazú, María Inés Alvarez; Perna, Oriana; Olivetti, Christian Ezequiel; Antezana, Pablo Edmundo; Municoy, Sofía; Tuttolomondo, María Victoria; Galdopórpora, Juan Manuel; Álvarez, Gisela Solange; Olmedo, Daniel Gustavo; Desimone, Martín Federico

doi:10.1002/mabi.202100383

Cited by 16 publications

(8 citation statements)

References 339 publications

(394 reference statements)

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“…Current progress in materials and cell biology has extensively indicated the superiority of multiple biomaterials for preclinical and clinical application upon diverse relapse and recurrent diseases, and in particular, the composites of biomaterials and MSC-exo for tissue engineering and regenerative purposes attribute to the unique biocompatibility. In details, biomaterials with biocompatible and biodegradable properties are capable of facilitating the efficacy of MSCs or MSC-exo and enhancing their manifestations during anti-tumor immunity by endowing the therapeutic ability of these encapsulated constituents [33][34][35]. To date, a variety of biomaterials have been introduced for MSC-exo-based regimens in biomedicine, such as hydrogel acid (HA) (e.g., ε-caprolactone (PCL)/nano-hydroxyapatite (nHA) scaffold, chitosan hydrogel, PCL/nHA + HPCH hybrid scaffolds), gelatin, and nanomaterials [12,36].…”

Section: Biomaterials/msc-exo Compositesmentioning

confidence: 99%

MSC-Derived Exosomes for Tissue Engineering and Disease Intervention

Zhang¹,

Gao²,

Ma³

et al. 2023

Exosomes - Recent Advances From Bench to Bedside

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Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells or multipotent stem cells, are heterogeneous cell populations with unique immunomodulatory feature and hematopoietic-supporting capacity. MSCs function through a variety of approaches including paracrine and autocrine, direct- or trans-differentiation, bidirectional immunomodulation, and serving as constitutive microenvironment. Of them, exosomes and microvesicles function as the pivotal vehicle for mediating the ameliorative and therapeutic effect of MSCs toward various recurrent and refractory diseases, such as xerophthalmia, radioactive nasal mucosa injury, acute-on-chronic liver failure (ACLF), dermal chronic ulcers, and intrauterine adhesions. State-of-the-art renewal has also highlighted the promising prospective of MSC-derived exosomes (MSC-exo) and diverse biomaterial composites in regenerative medicine. In this book chapter, we mainly focus on the concept, biological phenotypes, preclinical research, and clinical practice of MSC-derived exosomes (MSC-Exos) and/or biomaterials, which will collectively supply overwhelming new references for the further development of MSC-Exos-based biotherapy and disease diagnosis in future.

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Section: Biomaterials/msc-exo Compositesmentioning

confidence: 99%

MSC-Derived Exosomes for Tissue Engineering and Disease Intervention

Zhang¹,

Gao²,

Ma³

et al. 2023

Exosomes - Recent Advances From Bench to Bedside

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“…Compared to natural polymers, synthetic polymers can avoid triggering immune reactions in the human body and can be designed to functionally modify the polymer material to meet the desired function of the biomaterial without changing its intrinsic properties [ 64 ]. Polycaprolactone (PCL), poly (lactic acid/L-lactic acid) (PLA/PLLA), poly (glycolic acid) (PGA), poly (lactic-co-glycolic acid) (PLGA), poly (Ethylene Glycol) (PEG), and polyetheretherketone (PEEK) are the most studied synthetic polymers [ 65 , 66 ].…”

Section: Synthetic Polymersmentioning

confidence: 99%

Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration

et al. 2022

Polymers

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The musculoskeletal system plays a critical role in providing the physical scaffold and movement to the mammalian body. Musculoskeletal disorders severely affect mobility and quality of life and pose a heavy burden to society. This new field of musculoskeletal tissue engineering has great potential as an alternative approach to treating large musculoskeletal defects. Natural and synthetic polymers are widely used in musculoskeletal tissue engineering owing to their good biocompatibility and biodegradability. Even more promising is the use of natural and synthetic polymer composites, as well as the combination of polymers and inorganic materials, to repair musculoskeletal tissue. Therefore, this review summarizes the progress of polymer-based scaffolds for applications of musculoskeletal tissue engineering and briefly discusses the challenges and future perspectives.

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“…Polyurethanes, polyesters, metals such as titanium and other synthetic polymers have advantageous properties over natural ones especially because of their abundance, limitless designs and customizable attributes. They require, however, chemical alterations since they lack cell adhesion sites and are, therefore, considered to be less biocompatible [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

Different Species of Marine Sponges Diverge in Osteogenic Potential When Therapeutically Applied as Natural Scaffolds for Bone Regeneration in Rats

Santos

Prado

Fernandes

et al. 2023

JFB

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A highly porous structure, and an inorganic (biosilica) and collagen-like organic content (spongin) makes marine sponges potential candidates to be used as natural scaffolds in bone tissue engineering. The aim of this study was to characterize (through SEM, FTIR, EDS, XRD, pH, mass degradation and porosity tests) scaffolds produced from two species of marine sponges, Dragmacidon reticulatum (DR) and Amphimedon viridis (AV), and to evaluate the osteogenic potential of these scaffolds by using a bone defect model in rats. First, it was shown that the same chemical composition and porosity (84 ± 5% for DR and 90 ± 2% for AV) occurs among scaffolds from the two species. Higher material degradation was observed in the scaffolds of the DR group, with a greater loss of organic matter after incubation. Later, scaffolds from both species were surgically introduced in rat tibial defects, and histopathological analysis after 15 days showed the presence of neo-formed bone and osteoid tissue within the bone defect in DR, always around the silica spicules. In turn, AV exhibited a fibrous capsule around the lesion (19.9 ± 17.1%), no formation of bone tissue and only a small amount of osteoid tissue. The results showed that scaffolds manufactured from Dragmacidon reticulatum presented a more suitable structure for stimulation of osteoid tissue formation when compared to Amphimedon viridis marine sponge species.

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Recent Advances in Synthetic and Natural Biomaterials‐Based Therapy for Bone Defects

Cited by 16 publications

References 339 publications

MSC-Derived Exosomes for Tissue Engineering and Disease Intervention

MSC-Derived Exosomes for Tissue Engineering and Disease Intervention

Recent Advances in the Application of Natural and Synthetic Polymer-Based Scaffolds in Musculoskeletal Regeneration

Different Species of Marine Sponges Diverge in Osteogenic Potential When Therapeutically Applied as Natural Scaffolds for Bone Regeneration in Rats

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