Transformation of event representations along middle temporal gyrus

Leshinskaya, Anna; Thompson-Schill, Sharon L.

doi:10.1167/19.10.91a

Cited by 6 publications

(7 citation statements)

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“…Several previous investigations should also be mentioned here. Leshinskaya and Thompson-Schill (2020) suggested that perceptual features, newly acquired associations as well as generalizable relational knowledge manifest in neighboring regions of the lateral temporal areas. However, in contrast to our own observations, the authors did not find any evidence of associative coding in medial temporal lobes or the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Parallel cognitive maps for multiple knowledge structures in the hippocampal formation

Zheng,

Hebart,

Grill

et al. 2024

Cerebral Cortex

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The hippocampal-entorhinal system uses cognitive maps to represent spatial knowledge and other types of relational information. However, objects can often be characterized by different types of relations simultaneously. How does the hippocampal formation handle the embedding of stimuli in multiple relational structures that differ vastly in their mode and timescale of acquisition? Does the hippocampal formation integrate different stimulus dimensions into one conjunctive map or is each dimension represented in a parallel map? Here, we reanalyzed human functional magnetic resonance imaging data from Garvert et al. (2017) that had previously revealed a map in the hippocampal formation coding for a newly learnt transition structure. Using functional magnetic resonance imaging adaptation analysis, we found that the degree of representational similarity in the bilateral hippocampus also decreased as a function of the semantic distance between presented objects. Importantly, while both map-like structures localized to the hippocampal formation, the semantic map was located in more posterior regions of the hippocampal formation than the transition structure and thus anatomically distinct. This finding supports the idea that the hippocampal-entorhinal system forms parallel cognitive maps that reflect the embedding of objects in diverse relational structures.

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Section: Discussionmentioning

confidence: 99%

Parallel cognitive maps for multiple knowledge structures in the hippocampal formation

Zheng,

Hebart,

Grill

et al. 2024

Cerebral Cortex

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“…This suggests our effects are relatively anatomically specific to the more posterior ROI, which is also in line with many of the findings on action and event knowledge in posterior aspects of MTG 25 . Effects were also specific to the right hemisphere, which we had pre-registered as the focus due to the right-lateralization of prior findings 35 .…”

Section: Resultsmentioning

confidence: 99%

“…We focused on right-lateralized MTG following our prior work showing relational memory for novel visual events, learned one week prior, in this area 35 as well as the many findings connecting this anatomical region to semantic memory for actions, tools, and events 25,26 . For visual stimuli, MTG responses are often bilateral 20,96,97 and include signatures of generalization for action categories across actors 98,99 , effectors 100 or physical manners of execution 101,102 and of event memory 103 .…”

Section: Relationship To Prior Work On Mtgmentioning

confidence: 99%

Integration of event experiences to build relational knowledge in the human brain

Leshinskaya

Nguyen

Ranganath

2022

Preprint

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We investigated how the human brain integrates experiences of specific events to build general knowledge about typical event structure. We examined an episodic area important for temporal relations, anterior-lateral entorhinal cortex (alEC), and a semantic area important for action concepts, middle temporal gyrus (MTG). Participants underwent fMRI while watching sequences of novel events and recalling their temporal relations over two sessions one week apart. Across different contexts, the roles of these events could either be consistent, or conflict; integrative representations should weaken in the conflicting condition. We found integrative representations that emerged quickly in alEC, and only subsequently in MTG, which showed a significant change across sessions. Thus, alEC is important in building integrative representations early in learning and may be a gateway to semantic knowledge in MTG. We suggest that both episodic and semantic systems participate in integrating new information when it is aligned with their content specializations.

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“…Yet in between episodic and semantic relational representations is a large empirical gap. Our work has shown that MTG represents novel temporal relations learned a week prior 35 but it is not well understood by what mechanisms MTG representations are updated with experience nor how episodic and semantic systems might work together to build new relational knowledge.…”

Section: Introductionmentioning

confidence: 95%

Section: Middle Temporal Gyrusmentioning

confidence: 99%

Integration of event experiences to build relational knowledge in the human brain

2023

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We investigated how the human brain integrates experiences of specific events to build general knowledge about typical event structure. We examined an episodic memory area important for temporal relations, anterior-lateral entorhinal cortex, and a semantic memory area important for action concepts, middle temporal gyrus, to understand how and when these areas contribute to these processes. Participants underwent functional magnetic resonance imaging while learning and recalling temporal relations among novel events over two sessions 1 week apart. Across distinct contexts, individual temporal relations among events could either be consistent or inconsistent with each other. Within each context, during the recall phase, we measured associative coding as the difference of multivoxel correlations among related vs unrelated pairs of events. Neural regions that form integrative representations should exhibit stronger associative coding in the consistent than the inconsistent contexts. We found evidence of integrative representations that emerged quickly in anterior-lateral entorhinal cortex (at session 1), and only subsequently in middle temporal gyrus, which showed a significant change across sessions. A complementary pattern of findings was seen with signatures during learning. This suggests that integrative representations are established early in anterior-lateral entorhinal cortex and may be a pathway to the later emergence of semantic knowledge in middle temporal gyrus.

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Transformation of event representations along middle temporal gyrus

Cited by 6 publications

References 0 publications

Parallel cognitive maps for multiple knowledge structures in the hippocampal formation

Parallel cognitive maps for multiple knowledge structures in the hippocampal formation

Integration of event experiences to build relational knowledge in the human brain

Integration of event experiences to build relational knowledge in the human brain

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