Transformation of cinnamic acid from trans- to cis-form raises a notable bactericidal and synergistic activity against multiple-drug resistant Mycobacterium tuberculosis

Chen, Yen-Ling; Huang, Shao‐Tsung; Sun, Fang-Ming; Chiang, Yu-Ling; Chiang, Chia-Jung; Tsai, Chia‐Jung; Weng, Chia‐Jui

doi:10.1016/j.ejps.2011.04.012

Cited by 96 publications

(59 citation statements)

References 35 publications

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“…Cinnamic acid is an example of a substance with 2 varied inhibition potencies. Transforming from cis-cinnamic acid to trans-cinnamic acid significantly increased the activity (120-fold), which is comparable to isoniazid and rifampicin [40], and seems to be a similar situation with the isolation of Alpinia galanga -1' -acetoxychavicol acetate. This pure compound from a popular Thai herb shows MIC values 0.2 and 0.7 µg/ml against sensitive and resistant reference strains, respectively.…”

Section: Extracts and Natural Substances Isolated From Plantssupporting

confidence: 49%

Anti-tubercular substances produced by plants

Polak¹,

Kapka‐Skrzypczak²

2017

J Pre Clin Clin Res.

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Tuberculosis is one of the common causes of death worldwide, and according to the World Health Organization, in 2015, about 10.4 mln people globally is suffering from that disease. Despite great development in medicine and discovery of many antimycobacterial drugs, tuberculosis remains an unsolved problem. The populations of countries in Africa, Asia and South America have difficult access to hygiene, medical care and medicines, and they therefore resort to consulting traditional practitioners who mainly use drugs from natural sources which they prepare themselves. Plants are the biggest source of such medicines and are used as extracts, decoctions or powders, often without any evidence of their actual activity. Isolates from plants sometimes contain unknown substances or some second metabolites of microorganisms. In vitro studies have shown that some of these medicines have effective antimycobacterial properties, even against clinical, resistant strains. This is hopeful in the situation where more and more cases of tuberculosis prove to be resistant to standard drugs. Extracts of medicinal plants are often synergistic with synthetic drugs. Substances with insufficient MIC can be a basis for derivatives which have better properties. This thesis summarizes the current international knowledge of the use of plant substances used in the treatment of tuberculosis that could be potential new antituberculous drugs.

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Section: Extracts and Natural Substances Isolated From Plantssupporting

confidence: 49%

Anti-tubercular substances produced by plants

Polak¹,

Kapka‐Skrzypczak²

2017

J Pre Clin Clin Res.

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show abstract

“…Cinnamic acid is a naturally occurring phenolic compound that shows antimicrobial activity. Chen et al (2011) showed that cis-cinnamic acid that was transformed from trans-cinnamic acid showed higher synergistic effect with INH or RIF against tuberculosis than trans-cinnamic acid. T. spicata var.…”

Section: Discussionmentioning

confidence: 99%

Antimycobacterial Activity Some Different Lamiaceae Plant Extracts Containing Flavonoids and Other Phenolic Compounds

Aşkun¹,

Tümen²,

Satıl³

et al. 2012

Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance

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“…Interestingly, and in line with our observation, the cis-form of CA and not its trans-form raises a notable synergistic bactericidal activity against multiple-drug-resistant Mycobacterium tuberculosis. It is tempting to speculate that also in this case c-CA blocks the MDR-transporters, resulting in the intracellular accumulation of the supplied antibiotics to levels required to kill the bacteria (Chen et al, 2011).…”

Section: Discussionmentioning

confidence: 99%