Transformation and bioaccessibility of lead induced by steamed bread feed in the gastrointestinal tract

Kan, Junhong; Sima, Jingke; Cao, Xinde

doi:10.1016/j.ecoenv.2016.11.025

Cited by 10 publications

(3 citation statements)

References 32 publications

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“…The concentration of Pb(NO 3 ) 2 for the adsorption test was 320 mg L −1 . [ 28 ] The different adsorbent doses, including 0.1, 0.2, 0.3, 0.4, and 0.5 g, were put into 100 mL simulated gastric fluid and stirred for 1 h. And the 4 mL intestinal fluid was added, and saturated NaHCO 3 solution was used to adjust the pH = 7 and then stirred for 4 h.…”

Section: Methodsmentioning

confidence: 99%

“…lavage is the mainstream solution for archenteric lead removal in clinical practice. [28][29] Proteins and polysaccharides in food quickly adsorb lead ions to prevent the absorption of lead ions by the digestive system, and gastrointestinal lavage removes protein/polysaccharide-lead ion complexes to achieve in vivo lead removal. These treatments can prevent lead ions from entering the blood to a certain extent, but two problems exist.…”

mentioning

confidence: 99%

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Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

Cao

Dong

et al. 2023

Adv Funct Materials

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Emerging adsorption technology shows great potential for Pb 2+ removal in the human body because of its high adsorption efficiency and easy operation. However, biosafety concerns in the human body limit the development of adsorbents in integrated lead removal for acute poisoning in humans from the gastrointestinal tract and even the blood. In this work, highly bio-safe and natural saccharomyces cerevisiae cells are immobilized on the interworking natural regenerated cellulose nanofibers network for integrated lead removal in the human body. High intrinsic biosafety of the aerogel is guaranteed due to the biocompatibility of aerogel composition and the absence of crosslinking substances. Attributing to the porous structure of cellulose nanofibrous scaffolds, saccharomyces cerevisiae cells are protected from shedding, and considerable loading sites for saccharomyces cerevisiae cells are ensured. Simultaneously, abundant functional groups on the saccharomyces cerevisiae cells exhibit superior adsorption ability with a saturated adsorption capacity of lead ions as high as 107 mg g −1 in the aquatic environment. After adsorption, Pb 2+ concentration decreases from 879.70 to 248.53 µg L −1 in the intestinal phase and from 400 to 186.29 µg L −1 (within a safe level) in blood, providing an attractive strategy for detoxification of integrated lead in the human body.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

Cao

Dong

et al. 2023

Adv Funct Materials

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“…An increase of Pb bioaccessibility in the intestinal phase can enhance its toxicity. According to Kan et al (2017), the Pb carbonates' transformation to soluble organic Pb-complexes at neutral pH explain the increase of Pb bioaccessibility.…”

Section: Pbmentioning

confidence: 99%

Arsenic and Lead Bioaccessibilities Measured With a Novel Reactor System Using the Mexican Standard and Pbet Methods: Comparison With in Vivo and in Vitro Reported Data

García-Rodríguez

Gutiérrez-Ruíz

Ceniceros‐Gómez

2021

RICA

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Contaminated soils can become exposure routes of elements toxic to human beings. The health risk of a toxic element by ingestion depends on its bioavailability in the gastrointestinal system, measured in vivo or in vitro. This study aimed to use a novel, versatile reactor (gastrointestinal simulation reactor system to determine bioaccessibility -GSRSB-) to measure lead and arsenic bioaccessibility in the gastric and intestinal phases by applying a modified physiologically based extraction test (PBET). Three composite samples of polluted soils with As (0.50 - 3.25%) and Pb (0.02 - 0.10%) and the certified reference material NIST 2710 were analyzed with this GSRSB-PBET method and the NOM-147 Mexican standard method, which uses an end-over-end shaker. All results were compared to one another. The NIST 2710 results were contrasted with those reported in vivo and in vitro by 14 laboratories. The (GSRSB-PBET) gastric phase ranges were 35.9-55.1 % (As) and 59.6-96.1 % (Pb), while (NOM-147) gastric phases were 35.8-60.4 % (As) and 61.0-70.7 % (Pb). The (GSRSB-PBET) intestinal phase ranges were 39.5-46.9 % (As) and 19.9-31.5 % (Pb). The As and Pb compounds and the stirring technique seem to influence bioaccessibility. On the other hand, the comparison of NIST 2710 results with those reported in vitro and in vivo indicated that As and Pb gastric bioaccessibility obtained with GSRSB-PBET falls into the in vivo results range, while NOM-147 results are higher and fall outside the in vivo range, possibly overestimating the risk. Thus, the proposed method is adequate for modifying the current Mexican Standard Method (NOM-147), which only allows the calculation of Pb gastric bioavailability in vitro.

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Bioaccessibility and radioisotopes of lead in soils around a fertilizer industry in Lebanon

Saba¹,

Manouchehri²,

Besançon³

et al. 2019

Environ Geochem Health

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Transformation and bioaccessibility of lead induced by steamed bread feed in the gastrointestinal tract

Cited by 10 publications

References 32 publications

Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

Arsenic and Lead Bioaccessibilities Measured With a Novel Reactor System Using the Mexican Standard and Pbet Methods: Comparison With in Vivo and in Vitro Reported Data

Bioaccessibility and radioisotopes of lead in soils around a fertilizer industry in Lebanon

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