Biosafe Saccharomyces Cerevisiae Immobilized Nanofibrous Aerogels for Integrated Lead Removal in Human Body

Abstract

Emerging adsorption technology shows great potential for Pb 2+ removal in the human body because of its high adsorption efficiency and easy operation. However, biosafety concerns in the human body limit the development of adsorbents in integrated lead removal for acute poisoning in humans from the gastrointestinal tract and even the blood. In this work, highly bio-safe and natural saccharomyces cerevisiae cells are immobilized on the interworking natural regenerated cellulose nanofibers network for integrated lead removal in the human body. High intrinsic biosafety of the aerogel is guaranteed due to the biocompatibility of aerogel composition and the absence of crosslinking substances. Attributing to the porous structure of cellulose nanofibrous scaffolds, saccharomyces cerevisiae cells are protected from shedding, and considerable loading sites for saccharomyces cerevisiae cells are ensured. Simultaneously, abundant functional groups on the saccharomyces cerevisiae cells exhibit superior adsorption ability with a saturated adsorption capacity of lead ions as high as 107 mg g −1 in the aquatic environment. After adsorption, Pb 2+ concentration decreases from 879.70 to 248.53 µg L −1 in the intestinal phase and from 400 to 186.29 µg L −1 (within a safe level) in blood, providing an attractive strategy for detoxification of integrated lead in the human body.

Hydrolytically stable nanosheets of Cu–imidazolate MOF for selective trapping and simultaneous removal of multiple heavy metal ions

“…For instance, Cao et al immobilised Saccharomyces cerevisiae cells on a natural regenerated cellulose nanofibers network for Pb removal in the human body. 11 Among the array of contemporary materials serving as adsorbents, metal-organic frameworks (MOFs) stand out as a compelling paradigm. Their noteworthy characteristics, including high surface area, surface functionality, modularity, and structural diversity, position MOFs as an intriguing choice for applications centred around adsorption.…”

“…For instance, Cao et al immobilised Saccharomyces cerevisiae cells on a natural regenerated cellulose nanofibers network for Pb removal in the human body. 11…”

Highly Efficient, Recyclable Microplastic Adsorption Enabled by Chitin Hydrogen Bond Network Rearrangement

“…[26,27] Overall, the highly porous and relatively stable structure of 𝛽/𝛼-CT foam with rough fibrous surface was formed by the dual effect of fiber embedding and the lyophilization process, which was conducive to rapid migration of the microplastic throughout the material to allow adequate contact. [28,29] To investigate the dynamic behavior of chitin molecules during material preparation, we constructed crystalline models of 𝛽-CT and 𝛽/𝛼-CT by molecular dynamic (MD) simulation. Upon geometry optimization in 0.1% aqueous acetic acid, the structures of 𝛽/𝛼-CT and 𝛽-CT underwent significant changes.…”

Activating Adsorption Sites of Waste Crayfish Shells via Chemical Decalcification for Efficient Capturing of Nanoplastics

“…However, the porous structures were obtained by high-temperature carbonization, and a huge number of potentially advantageous functional groups may be largely decreased. It has spurred enormous interest in removing pollutants with biomass materials (e.g., cellulose and chitin) by naturally possessing abundant active functional groups, such as hydroxyl, acetyl, and amino groups. Furthermore, enhanced pollutant removal performance of biomass-based materials was acquired with regular and porous structure design. , Multiple bottom-up strategies were explored to realize the ideal structure fabrication .…”