Transferrin receptor-mediated liposomal drug delivery: recent trends in targeted therapy of cancer

Mojarad-Jabali, Solmaz; Mahdinloo, Somayeh; Farshbaf, Masoud; Sarfraz, Muhammad; Fatahi, Yousef; Atyabi, Fatemeh; Valizadeh, Hadi

doi:10.1080/17425247.2022.2083106

Cited by 16 publications

(6 citation statements)

References 201 publications

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“…It is noteworthy that the gastric pH is maintained at 4.0–5.0 while in the fed condition, indicating the role of food intake in gastric pH [ 43 , 53 ]. Receptor-mediated endocytosis [ 54 ] is considered advantageous for the cellular uptake and transport across the GI epithelium and transferrin receptor 1 (TfR1) is an attractive target for drug delivery currently under evaluation [ 55 , 56 , 57 , 58 ]. TfR1 is a transmembrane glycoprotein with a critical role in cellular iron uptake through endocytosis of iron-binding proteins, transferrin, and ferritin [ 57 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Tract Stabilized Protein Delivery Using Disulfide Thermostable Exoshell System

Sadeghi

Mavelli

Vaidya

et al. 2022

IJMS

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Thermostable exoshells (tES) are engineered proteinaceous nanoparticles used for the rapid encapsulation of therapeutic proteins/enzymes, whereby the nanoplatform protects the payload from proteases and other denaturants. Given the significance of oral delivery as the preferred model for drug administration, we structurally improved the stability of tES through multiple inter-subunit disulfide linkages that were initially absent in the parent molecule. The disulfide-linked tES, as compared to tES, significantly stabilized the activity of encapsulated horseradish peroxidase (HRP) at acidic pH and against the primary human digestive enzymes, pepsin, and trypsin. Furthermore, the disulfide-linked tES (DS-tES) exhibited significant intestinal permeability as evaluated using Caco2 cells. In vivo bioluminescence assay showed that encapsulated Renilla luciferase (rluc) was ~3 times more stable in mice compared to the free enzyme. DS-tES collected mice feces had ~100 times more active enzyme in comparison to the control (free enzyme) after 24 h of oral administration, demonstrating strong intestinal stability. Taken together, the in vitro and in vivo results demonstrate the potential of DS-tES for intraluminal and systemic oral drug delivery applications.

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal Tract Stabilized Protein Delivery Using Disulfide Thermostable Exoshell System

Sadeghi

Mavelli

Vaidya

et al. 2022

IJMS

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“…In order to transport medications or biomolecules inside cells, biomimetic liposomes could be modified to bind to specific moieties or ligands. Biomimetic liposomes may also facilitate the slow or rapid release of their payload in response to predetermined stimuli in the cellular microenvironment ( 56 , 59 ).…”

Section: Biomimetic Nanostructures As the Targeted Drug Delivery Vehiclementioning

confidence: 99%

Implications of biomimetic nanocarriers in targeted drug delivery

et al. 2023

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Nanomaterials and nanostructures have shown fascinating performances in various biomedicine fields, from cosmetic to cancer diagnosis and therapy. Engineered nanomaterials can encapsulate both lipophilic and hydrophilic substances/drugs to eliminate their limitations in the free forms, such as low bioavailability, multiple drug administration, off-target effects, and various side effects. Moreover, it is possible to deliver the loaded cargo to the desired site of action using engineered nanomaterials. One approach that has made nanocarriers more sophisticated is the “biomimetic” concept. In this scenario, biomolecules (e.g., natural proteins, peptides, phospholipids, cell membranes) are used as building blocks to construct nanocarriers and/or modify agents. For instance, it has been reported that specific cells tend to migrate to a particular site during specific circumstances (e.g., inflammation, tumor formation). Employing the cell membrane of these cells as a coating for nanocarriers confers practical targeting approaches. Accordingly, we introduce the biomimetic concept in the current study, review the recent studies, challenge the issues, and provide practical solutions.

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“…According to recent studies, specific ligands can be expressed on the exosome membrane surface via gene modification, achieving the targeted exosome delivery (Huang et al, 2022). In brain tumor, the TfRs are highly expressed in brain microvascular endothelial cells (BMVECs) and GBM cell line for regulation of brain uptake of iron (Tortorella and Karagiannis, 2014;Choudhury et al, 2018;Mojarad-Jabali et al, 2022). T7 is a transferrin receptor (TfR)binding peptide with the sequence HAIYPRH.…”

Section: Graphical Abstractmentioning

confidence: 99%

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma

et al. 2022

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Glioblastoma (GBM) is the most malignant tumor of the central nervous system in adults. Irradiation (IR) and temozolomide (TMZ) play an extremely important role in the treatment of GBM. However, major impediments to effective treatment are postoperative tumor recurrence and acquired resistance to chemoradiotherapy. Our previous studies confirm that Yin Yang 1 (YY1) is highly expressed in GBM, whereby it is associated with cell dedifferentiation, survival, and therapeutic resistance. Targeted delivery of small interfering RNA (siRNA) without blood-brain barrier (BBB) restriction for eradication of GBM represents a promising approach for therapeutic interventions. In this study, we utilize the engineering technology to generate T7 peptide-decorated exosome (T7-exo). T7 is a peptide specifically binding to the transferrin receptor. T7-exo shows excellent packaging and protection of cholesterol-modified Cy3-siYY1 while quickly releasing payloads in a cytoplasmic reductive environment. The engineered exosomes T7-siYY1-exo could deliver more effciently to GBM cells both in vitro and in vivo. Notably, in vitro experiments demonstrate that T7-siYY1-exo can enhance chemoradiotherapy sensitivity and reverse therapeutic resistance. Moreover, T7-siYY1-exo and TMZ/IR exert synergistic anti-GBM effect and significantly improves the survival time of GBM bearing mice. Our findings indicate that T7-siYY1-exo may be a potential approach to reverse the chemoradiotherapy resistance in GBM.

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Transferrin receptor-mediated liposomal drug delivery: recent trends in targeted therapy of cancer

Cited by 16 publications

References 201 publications

Gastrointestinal Tract Stabilized Protein Delivery Using Disulfide Thermostable Exoshell System

Gastrointestinal Tract Stabilized Protein Delivery Using Disulfide Thermostable Exoshell System

Implications of biomimetic nanocarriers in targeted drug delivery

Kill two birds with one stone: Engineered exosome-mediated delivery of cholesterol modified YY1-siRNA enhances chemoradiotherapy sensitivity of glioblastoma

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