Transferrin Receptor Expression in Canine Lymphoma

Priest, Heather; McDonough, Sean P.; Erb, Hollis N.; Stokol, Tracy

doi:10.1177/0300985810377074

Cited by 4 publications

(1 citation statement)

References 41 publications

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“…The annual incidence of malignant lymphoma varies from 24 to 114 cases per 100.000 dogs (Dubson et al, 2002;Dorn et al, 1967;Priest et al, 2011). It is known that lymphoma can occur in dogs of all ages, but frequently medium aged subjects are affected (Teske, 1994).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Data Concerning Canine Lymphoma over a Ten-Year Period (2005-2014), in Cluj-Napoca, Romania

et al. 2016

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Lymphoma is one of the main neoplasms that affects dogs, representing 80-90% of all hematopoietic tumors and 8-9% of all tumors. In the current paper we assessed the incidence of canine lymphomas that were diagnosed in the Pathology Department (Faculty of Veterinary Medicine, Cluj-Napoca, Romania) over a ten-year period (2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014).The epidemiological data were collected from the records of the Pathology Department (Faculty of Veterinary Medicine, Cluj-Napoca, Romania) in the last decade. The investigation included dogs diagnosed with lymphoma, following necropsy analysis or assessment of biopsies or cytological samples collected by fine needle aspiration from lymph nodes. All collected specimens were analyzed for histopathological diagnosis. We analyzed the distribution of canine lymphoma in relation to age, breed and sex, as well as the proportion of each anatomical form of lymphoma. The highest prevalence of lymphoma was observed in dogs aged 6 to 9, in Mongrels, Rottweiler and German shepherd dogs, with a very small difference between males and females. 79.8% of the dogs in this study were diagnosed with multicentric lymphoma, 5.76% with the gastrointestinal form, 5.76% with the cutaneous form, 4.8% were extranodal lymphomas and 3.84% were mediastinal ones. The results we obtained are agree with the statistics cited in the research literature. Considering that canine lymphoma is a common tumor in individuals of various ages, sexes and breeds, further epidemiological reports may aid in the establishment of the main risk factors for this entity.

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Section: Introductionmentioning

confidence: 99%

Epidemiological Data Concerning Canine Lymphoma over a Ten-Year Period (2005-2014), in Cluj-Napoca, Romania

et al. 2016

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B‐Cell Tumors

Aresu¹,

Comazzi²,

Marconato³

et al. 2022

Schalm's Veterinary Hematology

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Expression of transferrin receptor‐1 (TFR‐1) in canine osteosarcomas

Vico

Martano

Maiolino

et al. 2020

Veterinary Medicine & Sci

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Due to high rates of proliferation and DNA synthesis, neoplastic cells have higher requirements of iron than normal cells. For that reason, neoplastic cells have remodelled iron metabolism pathways, over‐expressing genes encoding for iron uptake proteins, among which Transferrin Receptor‐1 (TFR‐1). Accumulating evidence has proven that overexpression of TFR‐1 and high Iron concentration, are both widespread condition of cancer cells, both essential to tumour onset and progression. We studied TFR‐1 and PCNA immunohistochemical expression in fifteen (15) Canine osteoblastic osteosarcomas (COS). After immunohistochemical staining, counting of TFR‐1 positive cells by two independent observers showed that 85%–95% of neoplastic cells were strongly labelled at cytoplasmic level by anti‐TFR‐1 antibody in all examined COS. Furthermore, 70%–80% of neoplastic cells were positively labelled at the nuclear level by PCNA. Surprisingly, about 100% of intratumour vascular endothelial cells were also positive, whereas extratumour vascular endothelial cells were negative. The latter is an interesting finding, as TFR‐1 is usually not expressed in normal vasculature, with the exception of normal brain vascular endothelium, where it allows transport of transferrin, and thus iron, into tissues, suggesting a similar function here to support cancer growth. The early results presented highlight the relevance of TFR‐1 expression in canine OS, suggesting therapies involving both TFR‐1 and Iron metabolisms in dogs with osteosarcoma should be developed.

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Transferrin Receptor Expression in Canine Lymphoma

Cited by 4 publications

References 41 publications

Epidemiological Data Concerning Canine Lymphoma over a Ten-Year Period (2005-2014), in Cluj-Napoca, Romania

Epidemiological Data Concerning Canine Lymphoma over a Ten-Year Period (2005-2014), in Cluj-Napoca, Romania

B‐Cell Tumors

Expression of transferrin receptor‐1 (TFR‐1) in canine osteosarcomas

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