Transferrin guided quasi-nanocuboid as tetra-enzymic mimics and biosensing applications

Chen, Qing; Hu, Bo; Zhang, Dandan; Ren, Qunxiang; Wang, Mengmeng; Li, Peifeng; Zhang, Yang

doi:10.1016/j.talanta.2021.123138

Cited by 7 publications

(4 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The DHAA further reacted with O-phenylenediamine to generate the fluorescent substance 3-(1,2-dihydroxyethyl) furo [3,4b]quinoxaline, which can be captured at 425 nm. When utilized in detection of AA in actual human serum, Trf-Mn 3 O 4 demonstrated satisfying results with optimal linear range from 0.5 × 10 −6 to 10 × 10 −6 m and the limit of detection of 0.24 × 10 −6 m. [221] [122] Copyright 2020, Elsevier. B) i) Multienzyme cascade reactions for the SERS detection of glucose based on the GOx/POD activities of AuNPs/Cu-TCPP(Fe).…”

Section: Small Moleculesmentioning

confidence: 98%

See 1 more Smart Citation

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Sheng

Ding

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

Nanomaterials with more than one enzyme‐like activity are termed multi‐enzymic nanozymes, which have received increasing attention in recent years and hold huge potential to be applied in diverse fields, especially for biosensing and therapeutics. Compared to single enzyme‐like nanozymes, multi‐enzymic nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, and environmentally‐responsive selectivity. Nevertheless, along with these merits, the catalytic mechanism and rational design of multi‐enzymic nanozymes are more complicated and elusive as compared to single‐enzymic nanozymes. In this review, we systematically discussed the multi‐enzymic nanozymes classification scheme based on the numbers/types of activities, the internal and external factors regulating the multi‐enzymatic activities, the rational design based on chemical, biomimetic, and computer‐aided strategies, and recent progress in applications attributed to the advantages of multi‐catalytic activities. Finally, current challenges and future perspectives regarding the development and application of multi‐enzymatic nanozymes are suggested. This review aims to deepen the understanding and inspire the research in multi‐enzymic nanozymes to a greater extent.This article is protected by copyright. All rights reserved

show abstract

Section: Small Moleculesmentioning

confidence: 98%

“…When utilized in detection of AA in actual human serum, Trf‐Mn 3 O 4 demonstrated satisfying results with optimal linear range from 0.5 × 10 −6 to 10 × 10 −6 m and the limit of detection of 0.24 × 10 −6 m . [ 221 ]…”

Section: Applications Of Multienzymic Nanozymesmentioning

confidence: 99%

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Sheng

Ding

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

show abstract

“…Currently, an increasing number of researchers have reported Mn-based nanozymes with CAT-like activity. [18,78,83,87] The catalytic mechanism of Mn-based nanozymes is similar to the natural CAT. [88] In Equation (1), the reaction equation for the decomposition of H 2 O 2 by CAT is shown.…”

Section: Mn-based Nanozymes With Cat-like Activitymentioning

confidence: 99%

Manganese‐Based Nanozymes: Preparation, Catalytic Mechanisms, and Biomedical Applications

Tang

Zhang

Sun

et al. 2022

Adv Healthcare Materials

View full text Add to dashboard Cite

Manganese (Mn) has attracted widespread attention due to its low-cost, nontoxicity, and valence-rich transition. Various Mn-based nanomaterials have sprung up and are employed in diverse fields, particularly Mn-based nanozymes, which combine the physicochemical properties of Mn-based nanomaterials with the catalytic activity of natural enzymes, and are attracting a surge of research, especially in the field of biomedical research. In this review, the typical preparation strategies, catalytic mechanisms, advances and perspectives of Mn-based nanozymes for biomedical applications are systematically summarized. The application of Mn-based nanozymes in tumor therapy and sensing detection, together with an overview of their mechanism of action is highlighted. Finally, the prospective directions of Mn-based nanozymes from five perspectives: innovation, activity enhancement, selectivity, biocompatibility, and application broadening are discussed.

show abstract

“…It has been shown that some nanomaterials can exhibit dual or multiple enzyme mimetic activities simultaneously. For instance, Fe 3 O 4 NPs have shown pH‐dependent POD [ 20 ] and CAT [ 21 ] ‐like activities ( Figure A); CeO 2 NPs exhibit CAT and SOD‐like activities [ 22 ] (Figure 1B,C); Mn 3 O 4 NPs can mimic multiple anti‐oxidant enzymes, including SOD [ 23 ] and CAT [ 24 ] mimetic activities. Additionally, gold NPs (AuNPs) have been reported to exhibit multiple enzyme‐like activities, functioning as POD, glucose oxidase (GOx), [ 25 ] CAT, [ 26 ] SOD, nuclease, [ 27 ] and esterase‐like activities [ 28 ] (Figure 1D).…”

Section: Introductionmentioning

confidence: 99%

Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers

Wang,

Liu,

Fan

2023

Small Methods

View full text Add to dashboard Cite

Nanozymes show great promise in enhancing disease biomarker sensing by leveraging their physicochemical properties and enzymatic activities. These qualities facilitate signal amplification and matrix effects reduction, thus boosting biomarker sensing performance. In this review, recent studies from the last five years, concentrating on disease biomarker detection improvement through nanozyme‐based biosensing are examined. This enhancement primarily involves the modulations of the size, morphology, doping, modification, electromagnetic mechanisms, electron conduction efficiency, and surface plasmon resonance effects of nanozymes for increased sensitivity. In addition, a comprehensive description of the synthesis and tuning strategies employed for nanozymes has been provided. This includes a detailed elucidation of their catalytic mechanisms in alignment with the fundamental principles of enhanced sensing technology, accompanied by the presentation of quantitatively analyzed results. Moreover, the diverse applications of nanozymes in strip sensing, colorimetric sensing, electrochemical sensing, and surface‐enhanced Raman scattering have been outlined. Additionally, the limitations, challenges, and corresponding recommendations concerning the application of nanozymes in biosensing have been summarized. Furthermore, insights have been offered into the future development and outlook of nanozymes for biosensing. This review aims to serve not only as a reference for enhancing the sensitivity of nanozyme‐based biosensors but also as a catalyst for exploring nanozyme properties and their broader applications in biosensing.

show abstract

Transferrin guided quasi-nanocuboid as tetra-enzymic mimics and biosensing applications

Cited by 7 publications

References 45 publications

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Manganese‐Based Nanozymes: Preparation, Catalytic Mechanisms, and Biomedical Applications

Signal Amplification Strategy Design in Nanozyme‐Based Biosensors for Highly Sensitive Detection of Trace Biomarkers

Contact Info

Product

Resources

About