“…32,40 Beyond cancer therapy, TfR-targeting peptides on the surface of polymer and lipid-based nanocarriers have been developed to treat tuberculosis, microtubule accumulation in Alzheimer's disease models, and neuroinflammation in animal models. [41][42][43] While TfR is the most well-represented receptor for brain targeting in modern literature, multiple other peptide classes have been utilized for brain delivery of nanoscale materials. Apolipoproteins are a class of proteins responsible for traffick- ing lipids and cholesterol derivatives into the brain and have been identified as promising BBB targets.…”