Transferrin Concentration in Seminal Plasma with Special Reference to Serum Hormone Levels in Infertile Men

Irisawa, Chiaki; Nakada, Teruhiro; Kubota, Yōko; Sasagawa, Isoji; Yaguchi, Hiromasa

doi:10.3109/01485019308988363

Cited by 6 publications

(2 citation statements)

References 15 publications

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“…Using transferrin immunolabeling 30,70 we showed that left-sided varicocele caused a decrease in both global and VII/VIII stage-specific transferrin in rats, indicating a functional alteration in the Sertoli cell. Under normal conditions, transferrin mRNA levels vary twofold across the complete cycle, being high during the stages XII to XIV and achieving its maximum at stages VII and VIII.…”

Section: Discussionmentioning

confidence: 89%

Sertoli Cell Alterations in Peripubertal Varicocelized Rats: Evidence of Primary Damage on Spermatogenesis

Vaz

Paccola

Mendes

et al. 2020

J Histochem Cytochem.

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Idiopathic varicocele is closely associated with male infertility or subfertility. Sertoli cell is a very important regulator of spermatogenesis. We investigated the morphofunctional alterations in the Sertoli cell and its possible involvement in the establishment of testicular primary lesion in experimental left-sided varicocele, induced from peripuberty. Twenty-five male peripubertal rats (44 days postpartum [dpp]) were distributed into two groups: control (C) and varicocele (V). Experimental left varicocele was induced in rats through the partial ligature of the left renal vein. Euthanasia was performed at 100 dpp. Testicular histopathology and testosterone plasmatic level were evaluated. Transferrin and vimentin proteins were, respectively, used as immunomarkers of Sertoli cell function and structure. Significant reductions in vimentin and transferrin expressions were noticed in androgen-dependent stages (VII and VIII) of the seminiferous epithelium cycle in V rats; testosterone plasmatic level was also reduced. Bilateral testicular histopathological alterations were found in V rats, mainly massive germ cell desquamation. The histological damage and changes in protein expressions occurred bilaterally. The relevant impairment of the functional and structural characteristics of the Sertoli cell, together with the typical massive germ cell desquamation, indicates that Sertoli cell changes can primarily contribute to the significant testicular dysfunction associated with varicocele.

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Section: Discussionmentioning

confidence: 89%

Sertoli Cell Alterations in Peripubertal Varicocelized Rats: Evidence of Primary Damage on Spermatogenesis

Vaz

Paccola

Mendes

et al. 2020

J Histochem Cytochem.

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“…In the present study there was no relationship (P > 0.05) between ST levels and hormones (Table 2) which is corroborated by studies of Fuse (8) and Ber (9). However, there are studies that show as Tfs was inversely correlated with serum levels of LH, FSH and prolactin (10,11). ST levels found were significantly lower in the cases in relation to control in agreement with previous studies conducted by different researchers in non-uremic populations with suspected sub/infertility.…”

Section: Discussionmentioning

confidence: 99%