Transfer RNA-derived non-coding RNAs (tncRNAs): Hidden regulation of plants' transcriptional regulatory circuits

Zahra, Shafaque; Singh, Ajeet; Poddar, Nikita; Kumar, Shailesh

doi:10.1016/j.csbj.2021.09.021

Cited by 10 publications

(14 citation statements)

References 71 publications

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“…These observations further suggested that tsRNAs are not random degradation products, but potential regulators during stress responses. Accumulating data showed that the expression of plant tsRNAs can be regulated by Pi starvation ( Hsieh et al., 2009 ; Hackenberg et al., 2013 ), heat stress ( Wang et al., 2016 ), UV treatment ( Cognat et al., 2017 ) and fungal infection ( Zahra et al., 2021 ; Gu et al., 2022 ; Sun et al., 2022 ), indicating the possible function of these tsRNAs in plant stress responses ( Table 1 ).…”

Section: Expression Of Tsrnas Under Stressesmentioning

confidence: 99%

tRNA-derived small RNAs in plant response to biotic and abiotic stresses

et al. 2023

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tRNA-derived small RNAs (tsRNAs) represent a novel category of small non-coding RNAs and serve as a new regulator of gene expression at both transcriptional and post-transcriptional levels. Growing evidence indicates that tsRNAs can be induced by diverse stimuli and regulate stress-responsive target genes, allowing plants to adapt to unfavorable environments. Here, we discuss the latest developments about the biogenesis and classification of tsRNAs and highlight the expression regulation and potential function of tsRNAs in plant biotic and abiotic stress responses. Of note, we also collect useful bioinformatics tools and resources for tsRNAs study in plants. Finally, we propose current limitations and future directions for plant tsRNAs research. These recent discoveries have refined our understanding of whether and how tsRNAs enhance plant stress tolerance.

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Section: Expression Of Tsrnas Under Stressesmentioning

confidence: 99%

tRNA-derived small RNAs in plant response to biotic and abiotic stresses

et al. 2023

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“…Similarly, exosomal transfer RNAs (tRNA) have shown to be in greater amounts in patients of certain disease as compared to healthy individuals [ 14 ]. Nevertheless, the exact mechanism of tRNA fragments is uncertain, but they regulate some pathways and transfer components to other cells to be recognized [ 15 , 16 ]. In addition, PIWI-interacting RNAs (piRNAs) are one of the largest classes of noncoding RNA (ncRNA) molecules found in the extracellular environment and reside in EVs.…”

Section: Exosome Biologymentioning

confidence: 99%

Multifaceted roles of extracellular RNAs in different diseases

Sohail

Khawar²,

Ali

et al. 2022

Military Med Res

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Extracellular RNAs (exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNAs, with clinical and lab trials, that can be used as viable markers for different diseases.

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“…In tandem with TEs, transfer RNAs also partake in the etiology of neurodevelopmental disorders ( Blaze and Akbarian, 2022 ). TEs have been associated with shorter transfer RNA-derived RNA fragments in plants ( Zahra et al, 2021 ), which are known to inhibit translation and modulate immune response ( Blaze and Akbarian, 2022 ). Therefore, this may be another avenue worth exploring for TE pathogenesis in developmental diseases and disorders.…”

Section: When Transposable Elements Go Awrymentioning

confidence: 99%

The Role of Transposable Elements in Sexual Development

Chiang

DeRosa

Park

et al. 2022

Front. Behav. Neurosci.

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Up to 50% of most mammalian genomes are made up of transposable elements (TEs) that have the potential to mobilize around the genome. Despite this prevalence, research on TEs is only beginning to gain traction within the field of neuroscience. While TEs have long been regarded as “junk” or parasitic DNA, it has become evident that they are adaptive DNA and RNA regulatory elements. In addition to their vital role in normal development, TEs can also interact with steroid receptors, which are key elements to sexual development. In this review, we provide an overview of the involvement of TEs in processes related to sexual development- from TE activity in the germline to TE accumulation in sex chromosomes. Moreover, we highlight sex differences in TE activity and their regulation of genes related to sexual development. Finally, we speculate on the epigenetic mechanisms that may govern TEs’ role in sexual development. In this context, we emphasize the need to further the understanding of sexual development through the lens of TEs including in a variety of organs at different developmental stages, their molecular networks, and evolution.

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Transfer RNA-derived non-coding RNAs (tncRNAs): Hidden regulation of plants' transcriptional regulatory circuits

Abstract: Graphical abstract

Cited by 10 publications

References 71 publications

tRNA-derived small RNAs in plant response to biotic and abiotic stresses

tRNA-derived small RNAs in plant response to biotic and abiotic stresses

Multifaceted roles of extracellular RNAs in different diseases

The Role of Transposable Elements in Sexual Development

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