Transfer of perfluoroalkyl substances from mother to fetus in a Spanish birth cohort

Manzano-Salgado, Cyntia B.; Casas, Maribel; Lopez-Espinosa, Maria-José; Ballester, Ferrán; Basterrechea, Mikel; Grimalt, Joan O.; Jiménez-Zabala, Ana; Kraus, Thomas; Schettgen, Thomas; Sunyer, Jordi; Vrijheid, Martine

doi:10.1016/j.envres.2015.07.020

Cited by 121 publications

(98 citation statements)

References 45 publications

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“…concentrations support previous measurements from pregnant women (Monroy et al, 2008;Okada et al, 2013Okada et al, , 2014Cho et al, 2015;Manzano-Salgado et al, 2015;Papadopoulou et al, 2015;Callan et al, 2016;Wang et al, 2016). PFUnDA has been previously detected both at higher and lower concentrations (Okada et al, 2013;Callan et al, 2016;Wang et al, 2016).…”

Section: Pfassupporting

confidence: 89%

“…The differences in foetal uptake may be due to differences in placental clearance or exposure duration. Previously, foetal concentrations of PFOS, PFOA, and PFNA have been estimated from the concentrations in the umbilical cord blood (Monroy et al, 2008;de Cock et al, 2014;Manzano-Salgado et al, 2015). Our results help qualify estimations of foetal exposure by providing actual measured concentrations.…”

Section: Pfass In Human Foetal Organs In Relation To Maternal Concentsupporting

confidence: 55%

See 1 more Smart Citation

Concentration of perfluorinated compounds and cotinine in human foetal organs, placenta, and maternal plasma

Mamsen

Jönsson

Lindh

et al. 2017

Science of The Total Environment

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PFASs were transferred from mother to foetus, however, with different efficiencies. The concentrations of PFOS, PFOA, PFNA, PFUnDA, and PFDA in foetal organs were much lower than the maternal concentrations. Furthermore, a significant correlation between the exposure duration and all of the evaluated PFASs was found. The health-compromising concentrations of these substances during foetal development are unknown.

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Section: Pfassupporting

confidence: 89%

Section: Pfass In Human Foetal Organs In Relation To Maternal Concentsupporting

confidence: 55%

Concentration of perfluorinated compounds and cotinine in human foetal organs, placenta, and maternal plasma

Mamsen

Jönsson

Lindh

et al. 2017

Science of The Total Environment

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“…1. The median PFHxS level of cord serum in this study (3.87 ng/mL) is much higher than those found in most reported findings, such as South Africa (0.3 ng/mL) (Hanssen et al 2010), Spain (0.4 ng/mL) (Manzano-Salgado et al 2015), Korea (0.57 ng/mL in 2011) , and China (0.06 ng/mL) (Liu et al 2011). However, consistent with our results, an investigation from the Faroe Islands (Needham et al 2011) collected 15 sets of maternal and cord blood, and milk in 2000, showing that PFHxS levels in cord serum (9.1 ng/mL) were higher than PFOS (6.6 ng/mL) or PFOA (3.1 ng/mL).…”

Section: The Pfass Concentration In Cord Serumcontrasting

confidence: 73%

“…It is known that the type of functional group and the carbon length could affect the transplacental transfer efficiency. For example, shorter chain PFASs are transferred more easily than long chain (Beesoon et al 2011;Manzano-Salgado et al 2015;Monroy et al 2008). In the study from Needham et al (2011), the higher ratio of transplacental transfer in PFHxS (median ratio of 0.74) than PFOA (median ratio of 0.72) and PFOS (median ratio of 0.34) was observed.…”

Section: The Pfass Concentration In Cord Serummentioning

confidence: 98%

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

Zhang

Zeng

Qian

et al. 2017

Environ Sci Pollut Res

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Perfluoroalkyl substances (PFASs) are a class of widely used chemicals that have been detected in the environment and general population. However, the isomer patterns in human are poorly characterized. Previous studies observed the isomer-specific maternal-fetal transfer of PFASs in human. In our current study, we first examined the profile of PFASs and isomers, including 17 linear PFASs and 10 branched PFOS/PFOA isomers by using isotopic internal standards in umbilical cord serum samples from Guangzhou, China. We collected a total of 321 of cord blood serum samples from July to October in 2013, and analyzed the PFASs concentration with isomer-specific PFASs analysis method. The results showed that 9 out of 17 PFASs (linear PFASs) were detected (>50% detection rate). Perfluorohexane sulfonate (PFHxS, median 3.87 ng/mL) was the predominant, followed by total PFOS (median 2.99 ng/mL) and total PFOA (median 1.23 ng/mL) in cord serum. In addition, 1m-, iso-, ∑3+4+5m-PFOS and iso-PFOA were the branched PFASs detected in the current study. The proportion of linear PFOS (n-PFOS) was 75.16% of ∑PFOS which was similar to the proportion of electrochemical fluorination that produces ca. 70% linear PFOS and 30% branched. On the contrary, linear PFOA (n-PFOA) accounted for 98.69% ∑PFOA in cord serum samples. Our finding indicates distinct PFASs and PFOS/PFOA isomer profile in cord serum, suggesting there might be a different exposure pathway and metabolism of PFASs.

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“…There is evidence that PFASs accumulate in fetal tissue with different efficiencies, and differential transfer of compounds from maternal plasma to fetal tissue may explain our findings (35–37). A study of Danish women found that of 5 PFASs analyzed (PFOS, PFOA, PFNA, PFDA, PFUnDA), PFDA and PFUnDA had the highest concentrations in both placenta and fetal tissues relative to maternal concentrations (36).…”

Section: Discussionmentioning

confidence: 69%

Maternal Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Breastfeeding Duration in the Norwegian Mother and Child Cohort

Rosen

Brantsæter

Carroll

et al. 2018

Environmental Epidemiology

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Background Per- and polyfluoroalkyl substances (PFASs) have been widely produced, many of them persist in the environment, and have been associated with various health effects. Previous studies have identified inverse associations between perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and breastfeeding duration, but have been limited in investigation of other PFASs. Methods We measured the associations between plasma concentrations of 9 different PFASs and cessation of breastfeeding before 3 and 6 complete months using women from the Norwegian Mother and Child Cohort Study (MoBa). The study population includes 1716 primarily nulliparous women from two previous studies of MoBa participants, enrolled from 2003–2007. The association was measured using Cox proportional hazards model. Mixtures analyses were performed using Elastic net regularization to identify interactive effects and control for co-pollutant confounding. Results Concentrations of PFASs in this population were lower than concentrations in the previous studies on this topic. We found associations between increasing concentrations of perfluorononanoic acid (PFNA), perfluorodecaconic acid (PFDA), perfluoroundecanoic acid (PFUnDA) and decreased breastfeeding cessation (increased duration). The strongest associations were seen between PFDA and PFUnDA and cessation before 3 months: (both hazard ratios = 0.73, 95% confidence intervals: 0.62, 0.86). In our population, the other PFASs appeared to be unassociated with breastfeeding cessation. The mixtures analyses identified meaningful interactions between PFUnDA:PFDA, perfluorohexane sulfonate (PFHXS):PFOA and PFOA:PFOS. Conclusions The identification of associations between previously unexamined PFASs concentrations and increased breastfeeding duration is novel and may be explained by differences in transplacental transfer rates.

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Transfer of perfluoroalkyl substances from mother to fetus in a Spanish birth cohort

Abstract: Our results suggest that PFAS fetal body burden can be assessed using as proxy maternal plasma or serum collected early in pregnancy. Maternal age might influence PFAS placental transfer.

Cited by 121 publications

References 45 publications

Concentration of perfluorinated compounds and cotinine in human foetal organs, placenta, and maternal plasma

Concentration of perfluorinated compounds and cotinine in human foetal organs, placenta, and maternal plasma

Perfluoroalkyl substances with isomer analysis in umbilical cord serum in China

Maternal Plasma Concentrations of Per- and Polyfluoroalkyl Substances and Breastfeeding Duration in the Norwegian Mother and Child Cohort

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