Transfer of iodine through the milk in protein-restricted lactating rats

Passos, M. C. F.; Ramos, Cristiane da Fonte; Dutra, Sheila Cristina Potente; Moura, Egberto Gaspar de

doi:10.1016/s0955-2863(01)00142-5

Cited by 28 publications

(23 citation statements)

References 13 publications

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“…In rodents, the primordial follicles are formed by day 3 of age, and the first wave of follicles develops into antral follicles over the next 3 weeks (64)(65)(66). In agreement with the literature (55,67,68), our study showed that during this period, the PER group presents significant alterations in body weight. In addition, thyroid function and milk composition are altered at this time (55,67,68).…”

Section: Discussionsupporting

confidence: 91%

Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lactation

Ferreira

Gombar

Faria

et al. 2010

Fertility and Sterility

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Section: Discussionsupporting

confidence: 91%

Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lactation

Ferreira

Gombar

Faria

et al. 2010

Fertility and Sterility

Self Cite

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“…Those mothers probably had an increase in T 3 production, plus an increase in T 4 to T 3 conversion due to higher thyroid, brown adipose tissue and skeletal muscle deiodinase activities [85] . As stated above, protein malnourished mothers transfer more T 3 to their offspring [16] and lower iodine during the first 4 days of lactation [67] .…”

Section: Neonatal Malnutrition and Thyroid Function Programmingmentioning

confidence: 76%

“…To test if milk leptin transfer could have the same imprinting role, we injected leptin in the mother during the last 3 days of lactation [33,66] and found that it reproduces the increase in radioiodine milk transfer observed in PR dams [67] . Besides, to some extent, the offspring reproduced the effects observed when leptin was injected directly to the pups, i.e., as adults they displayed a higher body weight, higher food intake, hyperleptinemia and leptin resistance.…”

Section: Leptin and Body Weight Programmingmentioning

confidence: 99%

Neonatal Programming of Neuroimmunomodulation – Role of Adipocytokines and Neuropeptides

Moura¹,

Lisboa²,

Passos

2008

Neuroimmunomodulation

101

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Programming is an epigenetic phenomenon by which nutrition, environment and stress acting in a critical period earlier in life change the organism‘s development. This process was evolutionarily selected as an adaptive tool for the survival of organisms living in nutritionally deficient areas and submitted to stressful conditions. Thus, perinatal malnutrition turns on different genes that provide the organism with a thrifty phenotype. In conditions of abundant supply of nutrients, those programmed organisms can be at risk of developing metabolic diseases (obesity, dyslipidemia, diabetes and hypertension). How nutrition or neonatal stress can program the immune system is less well known. Here, we discuss some of the hormonal and metabolic changes that occur in mothers and neonates and how those factors can imprint hormonal or metabolic changes that program neuroimmunomodulatory effects. Some of these changes involve thyroid hormones, leptin, insulin, glucocorticoids and prolactin as potential imprinting factors. Most of them can be transferred through the milk and may change with malnutrition or stress. We discuss the programming effects of these hormones upon body weight, body composition, insulin action, thyroid, adrenal and immune and inflammatory responses, with special emphasis on leptin, a cytokine that seems to play a central role in these events.

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“…Some investigators have shown that the nutritional status of the mother during the gestational and lactational periods is essential to normal growth and development in humans (6)(7)(8) and in experimental animals (9)(10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…We have recently shown that proteinrestricted lactating dams present a loss of body weight gain (12), alterations in milk composition (11) and an important adaptive change in thyroid function by increasing the transfer of iodine and T 3 through the milk to their pups, probably preventing an eventual neonatal hypothyroidism (9,10,12).…”

Section: Introductionmentioning

confidence: 99%

Adaptive changes in thyroid function of female rats fed a high-fat and low-protein diet during gestation and lactation

Brito

Ramos

Passos

et al. 2006

Braz J Med Biol Res

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The percent of lipids in the western diet has been continuously increasing in the last decades and is associated with a decrease in the proportion of protein intake. Recently, we demonstrated that protein malnutrition during lactation is associated with lower body weight and thyroid hypofunction in female rats and their offspring. Our objective in the present study was to determine if a high-fat and lowprotein diet was associated with similar changes. Three-month-old female Wistar rats were randomly assigned to one of the following groups with 8 animals each: high-fat and low-protein (40% lipid, 5% protein, and 55% carbohydrate of the total energy content) from the 3rd week of gestation to the end of lactation; control group -standard diet (11% lipid, 23% protein, and 66% carbohydrate of the total energy content). Food consumption and body weight were monitored daily. Serum thyrotropin and thyroid hormone concentrations were determined by specific radioimmunoassay at the end of lactation. Animals receiving high-fat and low-protein diet had a significantly lower body weight (13.9% at weaning, P < 0.05) and serum albumin (25%, P < 0.05) and thyrotropin (26.2%, P < 0.01) concentrations, and a higher serum triiodothyronine concentration (74%, P < 0.005) and 131 I-thyroid uptake (77%, P < 0.005). These data show that a high-fat and low-protein diet can promote maternal thyroid hyperfunction that differs from the thyroid hypofunction observed in dams fed a lowprotein diet, a phenomenon that can be of adaptive importance for pup nurturing.

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Transfer of iodine through the milk in protein-restricted lactating rats

Cited by 28 publications

References 13 publications

Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lactation

Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lactation

Neonatal Programming of Neuroimmunomodulation – Role of Adipocytokines and Neuropeptides

Adaptive changes in thyroid function of female rats fed a high-fat and low-protein diet during gestation and lactation

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