Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lactation

Ferreira, R. V.; Gombar, Flavia Meireles; Faria, T.; Costa, Waldemar S.; Sampaio, Francisco J.B.; Ramos, Cristiane da Fonte

doi:10.1016/j.fertnstert.2009.05.050

Cited by 11 publications

(3 citation statements)

References 80 publications

(104 reference statements)

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“…The importance of adequate lactation to support establishment of ovarian reserve during early postnatal growth has been confirmed by a study in rats where maternal malnutrition during lactation was shown to adversely affect follicular numbers 37 …”

Section: Dohad and The Ovarymentioning

confidence: 96%

“…36 The importance of adequate lactation to support establishment of ovarian reserve during early postnatal growth has been confirmed by a study in rats where maternal malnutrition during lactation was shown to adversely affect follicular numbers. 37 Socioeconomic adversity in childhood has also been demonstrated to affect ovarian reserve by reducing the age at which women experience the menopause. The mechanism(s) by which this occurs is unknown but it is thought that it is likely to be secondary to poor nutrition and emotional stress.…”

Section: Intrauterine Nutritionmentioning

confidence: 99%

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The ‘Developmental Origins’ Hypothesis: relevance to the obstetrician and gynecologist

Kermack

Rijn

Houghton

et al. 2015

J Dev Orig Health Dis

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The recognition of 'fetal origins of adult disease' has placed new responsibilities on the obstetrician, as antenatal care is no longer simply about ensuring good perinatal outcomes, but also needs to plan for optimal long-term health for mother and baby. Recently, it has become clear that the intrauterine environment has a broad and long-lasting impact, influencing fetal and childhood growth and development as well as future cardiovascular health, non-communicable disease risk and fertility. This article looks specifically at the importance of the developmental origins of ovarian reserve and ageing, the role of the placenta and maternal nutrition before and during pregnancy. It also reviews recent insights in developmental medicine of relevance to the obstetrician, and outlines emerging evidence supporting a proactive clinical approach to optimizing periconceptional as well as antenatal care aimed to protect newborns against long-term disease susceptibility.

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Section: Dohad and The Ovarymentioning

confidence: 96%

Section: Intrauterine Nutritionmentioning

confidence: 99%

The ‘Developmental Origins’ Hypothesis: relevance to the obstetrician and gynecologist

Kermack

Rijn

Houghton

et al. 2015

J Dev Orig Health Dis

View full text Add to dashboard Cite

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“…Offspring of pregnant rats given a LP diet during gestation exhibit a reduction in capillary density in a variety of tissues, including skeletal muscle, endometrium, ovaries and pancreatic islets [5,[72][73][74] . Endothelial dilatation was similarly impaired [75] .…”

Section: Evidence That Early Nutritional Insults Impair β-Cell Regenementioning

confidence: 99%

Nutritional programming of pancreatic β-cell plasticity

Hill

2011

WJD

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Nutritional insufficiency during pregnancy has been shown to alter the metabolism of the offspring and can increase the risk of type 2 diabetes. The phenotype in the offspring involves changes to the morphology and functional capacity of the endocrine pancreas, and in the supporting islet microvasculature. �ancreatic β-cells possess a plastic potential and can partially recover from catastrophic loss. This is partly due to the existence of progenitors within the islets and the ability to generate new islets by neogenesis from the pancreatic ducts. This regenerative capacity is induced by bone marrow-derived stem cells, including endothelial cell progenitors and is associated with increased angiogenesis within the islets. Nutritional insults in early life, such as feeding a low protein diet to the mother, impair the regenerative capacity of the β-cells. The mechanisms underlying this include a reduced ability of β-cells to differentiate from the progenitor population, changes in the inductive signals from the microvasculature and an altered presence of endothelial progenitors. Statin treatment within animal models was associated with angiogenesis in the islet microvasculature, improved vascular function and an increase in β-cell mass. This demonstrates that reversal of the impaired β-cell phenotype observed following nutritional insult in early life is potentially possible.

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Preclinical Models of Altered Early Life Nutrition and Development of Reproductive Disorders in Female Offspring

Bridge-Comer

Vickers

Reynolds

2019

Reviews on Biomarker Studies of Metabolic and Metabolism-Related Disorders

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Metabolic programming of ovarian angiogenesis and folliculogenesis by maternal malnutrition during lactation

Cited by 11 publications

References 80 publications

The ‘Developmental Origins’ Hypothesis: relevance to the obstetrician and gynecologist

The ‘Developmental Origins’ Hypothesis: relevance to the obstetrician and gynecologist

Nutritional programming of pancreatic β-cell plasticity

Preclinical Models of Altered Early Life Nutrition and Development of Reproductive Disorders in Female Offspring

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