Preclinical Models of Altered Early Life Nutrition and Development of Reproductive Disorders in Female Offspring

Bridge-Comer, Pania E.; Vickers, Mark H.; Reynolds, Clare M.

doi:10.1007/978-3-030-12668-1_4

Cited by 5 publications

(11 citation statements)

References 140 publications

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“…Among the commonly used ingredients in this diet there are: biscuits, potato chips, peanut butter, chocolate, chocolate bars, cheese, sausage, jam, muffins, cakes, dried fruit 3 , 5 , 6 . CAF diet very well mimics “fast-food meals” popular among people 7 . It leads to development of obesity, characterized by increased body weight, changes in metabolic profiles, and inflammation 3 – 5 .…”

Section: Introductionmentioning

confidence: 99%

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Matuszewska

Zalewski

Klimaszyk

et al. 2021

Sci Rep

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Abstract“Western diet” containing high concentrations of sugar and fat consumed during pregnancy contributes to development of obesity and diabetes type 2 in offspring. To mimic effects of this diet in animals, a cafeteria (CAF) diet is used. We hypothesized that CAF diet given to rats before, and during pregnancy and lactation differently influences fat content, metabolic and inflammation profiles in offspring. Females were exposed to CAF or control diets before pregnancy, during pregnancy and lactation. At postnatal day 25 (PND 25), body composition, fat contents were measured, and blood was collected for assessment of metabolic and inflammation profiles. We have found that CAF diet lead to sex-specific alterations in offspring. At PND25, CAF offspring had: (1) higher percentage of fat content, and were lighter; (2) sex-specific differences in levels of glucose; (3) higher levels of interleukin 6 (IL-6), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α); (4) sex-specific differences in concentration of IL-6 and TNF-α, with an increase in CAF females; (5) higher level of IL-10 in both sexes, with a more pronounced increase in females. We concluded that maternal CAF diet affects fat content, metabolic profiles, and inflammation parameters in offspring. Above effects are sex-specific, with female offspring being more susceptible to the diet.

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Section: Introductionmentioning

confidence: 99%

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Matuszewska

Zalewski

Klimaszyk

et al. 2021

Sci Rep

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“…The CAF diet contains products are characterized by good taste combined with high energy density and includes such commonly used ingredients as biscuits, crisps, peanut butter, chocolate, chocolate bars, cheese, sausage, jam, muffins, cakes, and dried fruit [6,7]. Thus, CAF very well mimics the "fast food type" diet in humans [8] and its consumption results in the development of obesity in rodents [7,[9][10][11][12]. Offspring born to CAF mothers have altered body weight and fat content, as well as glucose, insulin, leptin, and triglyceride levels.…”

Section: Introductionmentioning

confidence: 99%

Maternal cafeteria diet influences kisspeptin (Kiss1), kisspeptin receptor(Gpr54), and sirtuin (Sirt1) genes, hormonal and metabolic profiles, and reproductive functions in rat offspring in a sex-specific manner

Matuszewska,

Nowacka-Woszuk,

Radziejewska

et al. 2023

Biology of Reproduction

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Kisspeptin (KP, encoded by Kiss1, binding to the Gpr54 receptor) is a neuropeptide conveying information on the metabolic status to the hypothalamic–pituitary–gonadal axis. KP acts together with dynorphin A (encoded by Pdyn) and neurokinin B (encoded by Tac2) to regulate reproduction. KP is crucial for the onset of puberty and is under the control of sirtuin (encoded by Sirt1). We hypothesize that the maternal cafeteria (CAF) diet has adverse effects on the offspring’s hormonal, metabolic, and reproductive functions due to sex-specific alterations in the expression of Kiss1, Gpr54, Pdyn, Tac2, and Sirt1 in the hypothalamus, and Kiss1, Gpr54, and Sirt1 in the liver. Rats were fed a CAF diet before pregnancy, during pregnancy, and during lactation. The vaginal opening was monitored. Offspring were sacrificed in three age points: PND 30, PND 35, and PND 60 (females) and PND 40, PND 45, and PND 60 (males). Their metabolic and hormonal status was assessed. mRNA for Kiss1, Gpr54, Pdyn, Tac2, and Sirt1 were measured by real-time PCR in the hypothalamus and/or livers. We found that CAF offspring had lower weight and altered body composition; increased cholesterol and triglyceride levels, sex-specific changes in glucose and insulin levels; sex-dependent changes in Sirt1/Kiss1 mRNA ratio in the hypothalamus; sex-specific alterations in Kiss1 and Sirt1 mRNA in the liver with more diversity in males; and a delayed puberty onset in females. We concluded that the mother’s CAF diet leads to sex-specific alterations in metabolic and reproductive outcomes via Kiss1/Gpr54 and Sirt1 systems in offspring.

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“…In addition, social class, stress, and trauma, whenever experienced, affect both biology and behavior, with consequences for pregnancy health, fecundability, and fertility decisions [ 8 ]. Developmental Origins of Health and Disease theory and research, while primarily focused on cardiometabolic health, also have been applied to reproductive outcomes [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Early-Life Exposures on Women’s Reproductive Health in Adulthood

2021

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Purpose of Review To review the effects of early-life, preconception, and prior-generation exposures on reproductive health in women. Recent Findings Women’s early-life factors can affect reproductive health by contributing to health status or exposure level on entering pregnancy. Alternately, they can have permanent effects, regardless of later-life experience. Nutrition, social class, parental smoking, other adverse childhood experiences, environmental pollutants, infectious agents, and racism and discrimination all affect reproductive health, even if experienced in childhood or in utero. Possible transgenerational effects are now being investigated through three- or more-generation studies. These effects occur with mechanisms that may include direct exposure, behavioral, endocrine, inflammatory, and epigenetic pathways. Summary Pregnancy is increasingly understood in a life course perspective, but rigorously testing hypotheses on early-life effects is still difficult. In order to improve the health outcomes of all women, we need to expand our toolkit of methods and theory. Supplementary Information The online version contains supplementary material available at 10.1007/s40471-021-00279-0.

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Preclinical Models of Altered Early Life Nutrition and Development of Reproductive Disorders in Female Offspring

Cited by 5 publications

References 140 publications

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Mothers’ cafeteria diet induced sex-specific changes in fat content, metabolic profiles, and inflammation outcomes in rat offspring

Maternal cafeteria diet influences kisspeptin (Kiss1), kisspeptin receptor(Gpr54), and sirtuin (Sirt1) genes, hormonal and metabolic profiles, and reproductive functions in rat offspring in a sex-specific manner

The Impact of Early-Life Exposures on Women’s Reproductive Health in Adulthood

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