Transepithelial elimination in necrobiosis lipoidica

Parra, Cristóbal A.

doi:10.1111/j.1365-2133.1977.tb05191.x

Cited by 53 publications

(28 citation statements)

References 5 publications

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“…Disorders illustrating TEE include the following: calcinosis cutis, osteoma perforans, granuloma annulare, elastosis perforans serpinginosa, reactive perforating collagenosis, per¬ forating folliculitis,1 and, recently, necrobiosis lipoidica diabeticorum. 3 This list should be expanded to include cutaneous chromomycosis, and, quite likely, other infectious granulomas. Zaias The precise mechanisms and mes¬ sages responsible for induction of TEE are not known.…”

Section: Commentmentioning

confidence: 99%

Transepithelial Elimination of Cutaneous Chromomycosis

Batres¹,

Wolf²,

Rudolph³

et al. 1978

Arch Dermatol

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Section: Commentmentioning

confidence: 99%

Transepithelial Elimination of Cutaneous Chromomycosis

Batres¹,

Wolf²,

Rudolph³

et al. 1978

Arch Dermatol

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“…[2] Rarely, transepidermal elimination and lymphoid follicle formation have been seen. [1011] In our series, we found the interstitial granulomatous pattern to be the commonest. A palisading granuloma with a tired appearance which is typically described in NL was seen in only one patient.…”

Section: Discussionmentioning

confidence: 53%

Necrobiosis lipoidica: A clinicopathological study in the Indian scenario

Thomas

Khopkar

2013

Indian Dermatol Online J

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Context:Necrobiosis lipoidica (NL) is a chronic granulomatous dermatitis that is commonly associated with diabetes mellitus. Most of the current knowledge about this entity is from western literature.Aims:This study evaluates the clinicohistological features of NL in an Indian scenario.Materials and Methods:We retrospectively reviewed clinical features, associated comorbidities, and biopsies of all patients with NL over a period of one year.Results:Five cases of NL were seen during the duration of the study. The preliminary clinical diagnosis ranged from sarcoidosis to tinea incognito. The commonest clinical presentation in the Indian scenario was of asymptomatic erythematous to skin-colored plaques and nodules on the shins with or without central atrophy. The most common site of involvement was the shin (3 of 5 patients). NL was associated with Diabetes mellitus in only two cases, both of whom were male patients. On histology, various patterns of inflammation were seen including the palisading, interstitial, and mixed granulomatous infiltrates. One patient had sarcoidal granulomas in association with an interstitial pattern. Features seen consistently in all cases include perivascular lymphoplasmacytic infiltrates, interstitial lymphocytic infiltrates, and fibroplasia. Interstitial mucin deposition was not observed in any of the biopsies.Conclusion:The diagnosis of NL was missed in most cases due to the rarity of the disease, absence of concomitant diabetes, and atypical presentations. Histology was a useful tool in clinching the diagnosis.

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“…The perforating variant was presented by Parra in 1977, who published 3 clinical cases of transfollicular elimination of degenerated collagen presenting clinically as hyperkeratotic plugs on the surface of the plaques [2]. …”

Section: Discussionmentioning

confidence: 99%

Perforating Disseminated Necrobiosis Lipoidica Diabeticorum

Lozanova

Dourmishev

Vassileva

et al. 2013

Case Reports in Dermatological Medicine

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Perforating necrobiosis lipoidica is a very rare clinical variant which consists of degeneration and transepidermal elimination of the collagen with few cases reported in the literature. In two-thirds of the patients it associates with diabetes, with no relation with the glucose control. We present a 42-year-old female patient with a 7-year history of diabetes on insulin therapy, referred to our clinic with a 3-year history of multiple asymptomatic firm plaques disseminated on the upper and lower extremities. The clinical and histological findings proved the diagnosis of perforating necrobiosis lipoidica.

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Transepithelial elimination in necrobiosis lipoidica

Abstract: SUMMARY Elimination of necrotic material through the hair follicle as a means of excretion has been observed in three cases of necrobiosis lipoidica. Clinically this process presents as comedo‐like plugs localized mainly in the periphery of the lesions.

Cited by 53 publications

References 5 publications

Transepithelial Elimination of Cutaneous Chromomycosis

Transepithelial Elimination of Cutaneous Chromomycosis

Necrobiosis lipoidica: A clinicopathological study in the Indian scenario

Perforating Disseminated Necrobiosis Lipoidica Diabeticorum

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