Transdermal Drug Delivery Systems Using Supersaturation

Rai, Vishwas; Raghavan, Lakshmi

doi:10.1007/978-3-662-45013-0_11

Cited by 6 publications

(1 citation statement)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These systems contain higher drug concentrations than the saturated solutions could be produced by several procedures such as hot-melt extrusion technology, heating and subsequent cooling and evaporation, etc. Addition of polymers (as anti-nucleants) to stabilize this thermodynamically variable state prevents crystallization and keeps the drug to remain in the solution form [144,145]. The mechanism of penetration enhancement is actually based on the thermodynamic activity of drugs with no modification in the configuration of the skin [146].…”

Section: (Ii) Supersaturation Systemsmentioning

confidence: 99%

Drug/Vehicle Impacts and Formulation Centered Stratagems for Enhanced Transdermal Drug Permeation, Controlled Release and Safety: Unparalleled Past and Recent Innovations-An Overview

Sreedharan

Chidambaram

2019

CDTH

View full text Add to dashboard Cite

: Transdermal drug delivery systems (TDDS) are one of the fascinating unconventional drug delivery systems offering plentiful advantages of which patient compliance is of paramount importance. However, as a matter of fact, the transdermal delivery of drug molecules is absolutely a tedious job which is precisely influenced by a number of factors including penetration barrier properties of the skin, drug characteristics formulation allied issues, etc. Over the years, innumerable tremendous efforts have been made in transporting the drugs through the skin into the systemic circulation by noteworthy tactics. This paper discusses such revolutionary formulation based techniques that have been endeavored in achieving the enhanced skin permeation of drugs, controlled release, and safety.

show abstract

Section: (Ii) Supersaturation Systemsmentioning

confidence: 99%